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Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells

  • Authors:
    • Hyung Tae Lee
    • Mi Ran Choi
    • Mi Sook Doh
    • Kyoung Hwa Jung
    • Young Gyu Chai
  • View Affiliations / Copyright

    Affiliations: Department of Molecular and Life Sciences, Hanyang University, Ansan 426-791, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1587-1592
    |
    Published online on: July 24, 2013
       https://doi.org/10.3892/or.2013.2635
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Abstract

Chemotherapy is one of the therapeutic strategies that has been used for the inhibition of cancer cell proliferation in several types of cancer, including prostate cancer. Although monoamine oxidase (MAO) inhibitors, phytoestrogen and antioxidants used in chemotherapy have been systematically studied, their effects on cancer cell growth remain to be fully understood. The purpose of this study was to investigate the effects of the MAO inhibitors, pargyline and tranylcypromine on cell survival in human prostate carcinoma (LNCaP-LN3) cells. After treating LNCaP-LN3 cells with pargyline or tranylcypromine, we examined cell proliferation, cell cycle pattern, apoptosis and the expression levels of apoptosis-related genes. The proliferation of cells exposed to pargyline decreased in a dose- and time-dependent manner, while tranylcypromine-treated cells showed the opposite results. Treatment with pargyline significantly induced cell cycle arrest at the G1 phase compared to the control and tranylcypromine-treated cells. In addition, pargyline induced an increase in the cell death rate by promoting apoptosis; however, tranylcypromine had no effect on LNCaP-LN3 cells. Based on our results, we suggest that pargyline is more powerful than tranylcypromine for the treatment of human prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Lee HT, Choi MR, Doh MS, Jung KH and Chai YG: Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncol Rep 30: 1587-1592, 2013.
APA
Lee, H.T., Choi, M.R., Doh, M.S., Jung, K.H., & Chai, Y.G. (2013). Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncology Reports, 30, 1587-1592. https://doi.org/10.3892/or.2013.2635
MLA
Lee, H. T., Choi, M. R., Doh, M. S., Jung, K. H., Chai, Y. G."Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells". Oncology Reports 30.4 (2013): 1587-1592.
Chicago
Lee, H. T., Choi, M. R., Doh, M. S., Jung, K. H., Chai, Y. G."Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells". Oncology Reports 30, no. 4 (2013): 1587-1592. https://doi.org/10.3892/or.2013.2635
Copy and paste a formatted citation
x
Spandidos Publications style
Lee HT, Choi MR, Doh MS, Jung KH and Chai YG: Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncol Rep 30: 1587-1592, 2013.
APA
Lee, H.T., Choi, M.R., Doh, M.S., Jung, K.H., & Chai, Y.G. (2013). Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncology Reports, 30, 1587-1592. https://doi.org/10.3892/or.2013.2635
MLA
Lee, H. T., Choi, M. R., Doh, M. S., Jung, K. H., Chai, Y. G."Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells". Oncology Reports 30.4 (2013): 1587-1592.
Chicago
Lee, H. T., Choi, M. R., Doh, M. S., Jung, K. H., Chai, Y. G."Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells". Oncology Reports 30, no. 4 (2013): 1587-1592. https://doi.org/10.3892/or.2013.2635
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