Significance of INHBA expression in human colorectal cancer

Okano,Miho; Yamamoto,Hirofumi; Ohkuma,Hisataka; Kano,Yoshihiro; Kim,Hirotoshi; Nishikawa,Shimpei; Konno,Masamitsu; Kawamoto,Koichi; Haraguchi,Naotsugu; Takemasa,Ichiro; Mizushima,Tsunekazu; Ikeda,Masataka; Yokobori,Takehiko; Mimori,Koshi; Sekimoto,Mitsugu; Doki,Yuichiro; Mori,Masaki; Ishii,Hideshi

doi:10.3892/or.2013.2761

December 2013 Volume 30 Issue 6

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December 2013 Volume 30 Issue 6

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Article

Significance of INHBA expression in human colorectal cancer

Authors:
- Miho Okano
- Hirofumi Yamamoto
- Hisataka Ohkuma
- Yoshihiro Kano
- Hirotoshi Kim
- Shimpei Nishikawa
- Masamitsu Konno
- Koichi Kawamoto
- Naotsugu Haraguchi
- Ichiro Takemasa
- Tsunekazu Mizushima
- Masataka Ikeda
- Takehiko Yokobori
- Koshi Mimori
- Mitsugu Sekimoto
- Yuichiro Doki
- Masaki Mori
- Hideshi Ishii
View Affiliations / Copyright

Affiliations: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan, Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan, Department of Surgery, Kyushu University Beppu Hospital, Oita 874-0838, Japan
Pages: 2903-2908
|
Published online on: October 1, 2013

https://doi.org/10.3892/or.2013.2761
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Abstract

Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC cell lines. Cell growth was assessed after inhibition of INHBA expression or after exogenous overexpression of INHBA in CRC tissues. INHBA expression was significantly higher in CRC tissues when compared to that in the corresponding normal tissues (P<0.001). Patients in the high expression group showed a poorer overall survival rate when compared to those in the low expression group (P<0.001); the present study did not evaluate for an independent prognostic factor but showed the significance of lymph node metastasis as an independent prognostic factor. The present study suggests that INHBA is useful as a predictive marker for prognosis in CRC patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Significance of INHBA expression in human colorectal cancer

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