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Review

FTY720 for cancer therapy (Review)

  • Authors:
    • Li Zhang
    • Han-Dong Wang
    • Xiang-Jun Ji
    • Zi-Xiang Cong
    • Jian-Hong Zhu
    • Yuan Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, P.R. China
  • Pages: 2571-2578
    |
    Published online on: October 1, 2013
       https://doi.org/10.3892/or.2013.2765
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Abstract

2-Amino-2-[2-(4-octylphenyl)]-1,3-propanediol hydrochloride (FTY720) is a potent immunosuppressant which has been approved by the Food and Drug Administration (FDA) as a new treatment for multiple sclerosis. As an immunosuppressant, it displays its anti-multiple sclerosis, immunosuppressive effects by activating sphingosine-1-phosphate receptors (S1PRs). In addition to the immunosuppressive effects, FTY720 also shows preclinical antitumor efficacy in several cancer models. In most cases, phosphorylation of FTY720 is not required for its cytotoxic effect, indicating the involvement of S1PR-independent mechanisms which are starkly different from the immunosuppressive property of FTY720. In the present study, we reviewed the rapidly advancing field of FTY720 in cancer therapy as well as some molecular targets of the unphosphorylated form of FTY720.
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1 

Billich A, Bornancin F, Dévay P, Mechtcheriakova D, Urtz N and Baumruker T: Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J Biol Chem. 278:47408–47415. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Paugh SW, Payne SG, Barbour SE, Milstien S and Spiegel S: The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett. 554:189–193. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Suzuki S, Enosawa S, Kakefuda T, et al: A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation. 61:200–205. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Enosawa S, Suzuki S, Kakefuda T, Li XK and Amemiya H: Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720. Immunopharmacology. 34:171–179. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Suzuki S, Li XK, Shinomiya T, et al: Induction of lymphocyte apoptosis and prolongation of allograft survival by FTY720. Transplant Proc. 28:2049–2050. 1996.PubMed/NCBI

6 

Suzuki S, Enosawa S, Kakefuda T, Amemiya H, Hoshino Y and Chiba K: Long-term graft acceptance in allografted rats and dogs by treatment with a novel immunosuppressant, FTY720. Transplant Proc. 28:1375–1376. 1996.PubMed/NCBI

7 

Suzuki S, Enosawa S, Kakefuda T, et al: Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats. Transplant Immunol. 4:252–255. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Pitman MR, Woodcock JM, Lopez AF and Pitson SM: Molecular targets of FTY720 (fingolimod). Curr Mol Med. 12:1207–1219. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Azuma H, Takahara S, Ichimaru N, et al: Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Res. 62:1410–1419. 2002.PubMed/NCBI

10 

Sonoda Y, Yamamoto D, Sakurai S, et al: FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells. Biochem Biophys Res Commun. 281:282–288. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Chua CW, Lee DT, Ling MT, et al: FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. Int J Cancer. 117:1039–1048. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Schmid G, Guba M, Papyan A, et al: FTY720 inhibits tumor growth and angiogenesis. Transplant Proc. 37:110–111. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Zhang N, Qi Y, Wadham C, et al: FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. Autophagy. 6:1157–1167. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Lee TK, Man K, Ho JW, et al: FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis. 25:2397–2405. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Vadas M, Xia P, McCaughan G and Gamble J: The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction? Biochim Biophys Acta. 1781:442–447. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Wang JD, Takahara S, Nonomura N, et al: Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation. Prostate. 40:50–55. 1999. View Article : Google Scholar

17 

Hu S, Vincenz C, Buller M and Dixit VM: A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis. J Biol Chem. 272:9621–9624. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Cohen GM: Caspases: the executioners of apoptosis. Biochem J. 326(Pt 1): 1–16. 1997.

19 

Zheng T, Meng X, Wang J, et al: PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. J Cell Biochem. 111:218–228. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Ubai T, Azuma H, Kotake Y, et al: FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Res. 27:75–88. 2007.PubMed/NCBI

21 

Yasui H, Hideshima T, Raje N, et al: FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res. 65:7478–7484. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Susin SA, Lorenzo HK, Zamzami N, et al: Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 397:441–446. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Liu Q, Alinari L, Chen CS, et al: FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma. Clin Cancer Res. 16:3182–3192. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Liu Q, Zhao X, Frissora F, et al: FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood. 111:275–284. 2008. View Article : Google Scholar

25 

Wallington-Beddoe CT, Hewson J, Bradstock KF and Bendall LJ: FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy. 7:707–715. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Liao A, Hu R, Zhao Q, et al: Autophagy induced by FTY720 promotes apoptosis in U266 cells. Eur J Pharm Sci. 45:600–605. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Alinari L, Baiocchi RA and Praetorius-Ibba M: FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment? Autophagy. 8:416–417. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Alinari L, Mahoney E, Patton J, et al: FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death. Blood. 118:6893–6903. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Levine B and Kroemer G: Autophagy in the pathogenesis of disease. Cell. 132:27–42. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Levine B and Yuan J: Autophagy in cell death: an innocent convict? J Clin Invest. 115:2679–2688. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Ogata M, Hino S, Saito A, et al: Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol. 26:9220–9231. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Wirawan E, Vanden Berghe T, Lippens S, Agostinis P and Vandenabeele P: Autophagy: for better or for worse. Cell Res. 22:43–61. 2012. View Article : Google Scholar

33 

Estrada-Bernal A, Palanichamy K, Ray Chaudhury A and Van Brocklyn JR: Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma. Neuro Oncol. 14:405–415. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Ng KT, Man K, Ho JW, et al: Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of downregulation of cell survival Akt pathway. Int J Oncol. 30:375–380. 2007.PubMed/NCBI

35 

Zhou C, Ling MT, Kin-Wah Lee T, Man K, Wang X and Wong YC: FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. Cancer Lett. 233:36–47. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Kappos L, Radue EW, O’Connor P, et al: A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 362:387–401. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Azuma H, Takahara S, Horie S, Muto S, Otsuki Y and Katsuoka Y: Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. J Urol. 169:2372–2377. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS and Lele RD: Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India. 52:794–804. 2004.PubMed/NCBI

39 

Hung JH, Lu YS, Wang YC, et al: FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Res. 68:1204–1212. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Omar HA, Chou CC, Berman-Booty LD, et al: Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology. 53:1943–1958. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Perrotti D and Neviani P: Protein phosphatase 2A: a target for anticancer therapy. Lancet Oncol. 14:e229–e238. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Yin X, Zhang N and Di W: Regulation of LC3-dependent protective autophagy in ovarian cancer cells by protein phosphatase 2A. Int J Gynecol Cancer. 23:630–641. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Yang Y, Huang Q, Lu Y, Li X and Huang S: Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation. J Cell Biochem. 113:1314–1322. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Saddoughi SA, Gencer S, Peterson YK, et al: Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med. 5:105–121. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Neviani P, Santhanam R, Trotta R, et al: The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell. 8:355–368. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Neviani P, Santhanam R, Oaks JJ, et al: FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J Clin Invest. 117:2408–2421. 2007. View Article : Google Scholar

47 

Cristobal I, Garcia-Orti L, Cirauqui C, Alonso MM, Calasanz MJ and Odero MD: PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Leukemia. 25:606–614. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Roberts KG, Smith AM, McDougall F, et al: Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. Cancer Res. 70:5438–5447. 2010. View Article : Google Scholar

49 

Manning G, Whyte DB, Martinez R, Hunter T and Sudarsanam S: The protein kinase complement of the human genome. Science. 298:1912–1934. 2002. View Article : Google Scholar : PubMed/NCBI

50 

Nagaoka Y, Otsuki K, Fujita T and Uesato S: Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Biol Pharm Bull. 31:1177–1181. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Lee YJ, Kim NY, Suh YA and Lee C: Involvement of ROS in curcumin-induced autophagic cell death. Korean J Physiol Pharmacol. 15:1–7. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Liu JM, Pan F, Li L, et al: Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. Biochem Biophys Res Commun. 437:87–93. 2013. View Article : Google Scholar

53 

Borders EB, Bivona C and Medina PJ: Mammalian target of rapamycin: biological function and target for novel anticancer agents. Am J Health Syst Pharm. 67:2095–2106. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Yap TA, Garrett MD, Walton MI, Raynaud F, de Bono JS and Workman P: Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol. 8:393–412. 2008. View Article : Google Scholar : PubMed/NCBI

55 

LoPiccolo J, Blumenthal GM, Bernstein WB and Dennis PA: Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat. 11:32–50. 2008. View Article : Google Scholar : PubMed/NCBI

56 

Alvarez M, Roman E, Santos ES and Raez LE: New targets for non-small-cell lung cancer therapy. Expert Rev Anticancer Ther. 7:1423–1437. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Rosell R, Felip E, Garcia-Campelo R and Balana C: The biology of non-small-cell lung cancer: identifying new targets for rational therapy. Lung Cancer. 46:135–148. 2004. View Article : Google Scholar : PubMed/NCBI

58 

Zheng J, Zou X and Yao J: The antitumor effect of GDC-0941 alone and in combination with rapamycin in breast cancer cells. Chemotherapy. 58:273–281. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Liao WT, Li TT, Wang ZG, et al: MicroRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2. Clin Cancer Res. 19:4662–4672. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Yothaisong S, Dokduang H, Techasen A, et al: Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. Tumour Biol. Jul 6–2013.(Epub ahead of print).

61 

Wu P and Hu YZ: PI3K/Akt/mTOR pathway inhibitors in cancer: a perspective on clinical progress. Curr Med Chem. 17:4326–4341. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Ghayad SE and Cohen PA: Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients. Recent Pat Anticancer Drug Discov. 5:29–57. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Cortot A, Armand JP and Soria JC: PI3K-AKT-mTOR pathway inhibitors. Bull Cancer. 93:19–26. 2006.(In French).

64 

Chua CW, Chiu YT, Yuen HF, et al: Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform. Clin Cancer Res. 15:4322–4335. 2009. View Article : Google Scholar : PubMed/NCBI

65 

Li MH, Hla T and Ferrer F: FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatr Blood Cancer. 60:1418–1423. 2013. View Article : Google Scholar : PubMed/NCBI

66 

Chang CY, Ma KH, Wang JK, Tung YL and Chueh SH: Inhibition of protein kinase C promotes differentiation of neuroblastoma x glioma NG108–15 hybrid cells. Eur J Neurosci. 34:1074–1084. 2011.

67 

Weng JR, Bai LY, Chiu CF, Hu JL, Chiu SJ and Wu CY: Cucurbitane triterpenoid from Momordica charantia induces apoptosis and autophagy in breast cancer cells, in part, through peroxisome proliferator-activated receptor gamma activation. Evid Based Complement Alternat Med. 2013:9356752013.PubMed/NCBI

68 

Tolba MF, Esmat A, Al-Abd AM, et al: Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells. IUBMB Life. 65:716–729. 2013. View Article : Google Scholar : PubMed/NCBI

69 

Li X, Pu J, Jiang S, et al: Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with beta-catenin/TCF4 interaction in colorectal cancer cells. PLoS One. 8:e685252013. View Article : Google Scholar : PubMed/NCBI

70 

Chung YC, Lu LC, Tsai MH, et al: The inhibitory effect of ellagic acid on cell growth of ovarian carcinoma cells. Evid Based Complement Alternat Med. 2013:3067052013. View Article : Google Scholar : PubMed/NCBI

71 

Li H, Sun L, Xu Y, et al: Overexpression of MTA3 correlates with tumor progression in non-small cell lung cancer. PLoS One. 8:e666792013. View Article : Google Scholar : PubMed/NCBI

72 

Chang MS, Kim DH, Roh JK, et al: Epstein-Barr virus-encoded BARF1 promotes proliferation of gastric carcinoma cells through regulation of NF-kappaB. J Virol. 87:10515–10523. 2013. View Article : Google Scholar : PubMed/NCBI

73 

Jiang J, Huang X, Wang Y, Deng A and Zhou J: FTY720 induces cell cycle arrest and apoptosis of rat glomerular mesangial cells. Mol Biol Rep. 39:8243–8250. 2012. View Article : Google Scholar : PubMed/NCBI

74 

Li QY, Chi YY and Liu SQ: Cell cycle arrest effects of large-dose FTY720 on lymphocytes in mouse skin transplantation models. Immunopharmacol Immunotoxicol. 30:365–381. 2008. View Article : Google Scholar : PubMed/NCBI

75 

Gulappa T, Reddy RS, Suman S, Nyakeriga AM and Damodaran C: Molecular interplay between cdk4 and p21 dictates G/G cell cycle arrest in prostate cancer cells. Cancer Lett. 337:177–183. 2013. View Article : Google Scholar : PubMed/NCBI

76 

Bermudez O, Hennen E, Koch I, Lindner M and Eickelberg O: Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation. PLoS One. 8:e632262013. View Article : Google Scholar : PubMed/NCBI

77 

Aigelsreiter A, Ress AL, Bettermann K, et al: Low expression of the putative tumour suppressor spinophilin is associated with higher proliferative activity and poor prognosis in patients with hepatocellular carcinoma. Br J Cancer. 108:1830–1837. 2013. View Article : Google Scholar

78 

Guo J, Gao J, Li Z, et al: Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. Cancer Lett. 339:185–194. 2013. View Article : Google Scholar : PubMed/NCBI

79 

Yoon JS, Kim HM, Yadunandam AK, et al: Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: Molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response. Phytomedicine. 20:1013–1022. 2013. View Article : Google Scholar

80 

Kurokawa K, Akaike Y, Masuda K, et al: Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells. Oncogene. March 18–2013.(Epub ahead of print).

81 

Xing Z, Zhang Y, Zhang X, Yang Y, Ma Y and Pang D: Fangchinoline induces G1 arrest in breast cancer cells through cell-cycle regulation. Phytother Res. Feb 11–2013.(Epub ahead of print).

82 

Steck PA, Pershouse MA, Jasser SA, et al: Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 15:356–362. 1997. View Article : Google Scholar : PubMed/NCBI

83 

Santoni M, Burattini L, Nabissi M, et al: Essential role of gli proteins in glioblastoma multiforme. Curr Protein Pept Sci. 14:133–140. 2013. View Article : Google Scholar : PubMed/NCBI

84 

Yang P, Wang Y, Peng X, et al: Management and survival rates in patients with glioma in China (2004–2010): a retrospective study from a single-institution. J Neurooncol. 113:259–266. 2013.PubMed/NCBI

85 

Brucka A and Szyłło K: Immunoexpression of the PTEN protein and matrix metalloproteinase-2 in endometrial cysts, endometrioid and clear cell ovarian cancer. Ginekol Pol. 84:344–351. 2013.PubMed/NCBI

86 

Abdulkareem IH and Blair M: Effects of indomethacin on expression of PTEN tumour suppressor in human cancers. Niger Med J. 54:100–106. 2013. View Article : Google Scholar : PubMed/NCBI

87 

McQuitty E, Zhang W, Hendrickson H, et al: Lung adenocarcinoma biomarker incidence in Hispanic versus non-Hispanic white patients. Arch Pathol Lab Med. Jun 26–2013.(Epub ahead of print).

88 

Filippini SE and Vega A: Breast cancer genes: beyond BRCA1 and BRCA2. Front Biosci. 18:1358–1372. 2013. View Article : Google Scholar : PubMed/NCBI

89 

Alshaker H, Sauer L, Monteil D, et al: Therapeutic potential of targeting SK1 in human cancers. Adv Cancer Res. 117:143–200. 2013. View Article : Google Scholar : PubMed/NCBI

90 

Lim KG, Tonelli F, Berdyshev E, et al: Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. Int J Biochem Cell Biol. 44:1457–1464. 2012. View Article : Google Scholar : PubMed/NCBI

91 

Rosa R, Marciano R, Malapelle U, et al: Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models. Clin Cancer Res. 19:138–147. 2013. View Article : Google Scholar : PubMed/NCBI

92 

Lim KG, Tonelli F, Li Z, et al: FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. J Biol Chem. 286:18633–18640. 2011. View Article : Google Scholar

93 

Tonelli F, Lim KG, Loveridge C, et al: FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell Signal. 22:1536–1542. 2010. View Article : Google Scholar

94 

Pitson SM: Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem Sci. 36:97–107. 2011. View Article : Google Scholar : PubMed/NCBI

95 

Li MH, Hla T and Ferrer F: Sphingolipid modulation of angiogenic factor expression in neuroblastoma. Cancer Prev Res (Phila). 4:1325–1332. 2011. View Article : Google Scholar : PubMed/NCBI

96 

Xu Z, Graham K, Foote M, et al: 14-3-3 targets chaperone-associated misfolded proteins to aggresomes. J Cell Sci. 126:4173–4186

97 

Zhang L, Chen J and Fu H: Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc Natl Acad Sci USA. 96:8511–8515. 1999. View Article : Google Scholar : PubMed/NCBI

98 

Woodcock JM, Ma Y, Coolen C, et al: Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. Cell Signal. 22:1291–1299. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Wang H, Ji X, Cong Z, Zhu J and Zhou Y: FTY720 for cancer therapy (Review). Oncol Rep 30: 2571-2578, 2013.
APA
Zhang, L., Wang, H., Ji, X., Cong, Z., Zhu, J., & Zhou, Y. (2013). FTY720 for cancer therapy (Review). Oncology Reports, 30, 2571-2578. https://doi.org/10.3892/or.2013.2765
MLA
Zhang, L., Wang, H., Ji, X., Cong, Z., Zhu, J., Zhou, Y."FTY720 for cancer therapy (Review)". Oncology Reports 30.6 (2013): 2571-2578.
Chicago
Zhang, L., Wang, H., Ji, X., Cong, Z., Zhu, J., Zhou, Y."FTY720 for cancer therapy (Review)". Oncology Reports 30, no. 6 (2013): 2571-2578. https://doi.org/10.3892/or.2013.2765
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Wang H, Ji X, Cong Z, Zhu J and Zhou Y: FTY720 for cancer therapy (Review). Oncol Rep 30: 2571-2578, 2013.
APA
Zhang, L., Wang, H., Ji, X., Cong, Z., Zhu, J., & Zhou, Y. (2013). FTY720 for cancer therapy (Review). Oncology Reports, 30, 2571-2578. https://doi.org/10.3892/or.2013.2765
MLA
Zhang, L., Wang, H., Ji, X., Cong, Z., Zhu, J., Zhou, Y."FTY720 for cancer therapy (Review)". Oncology Reports 30.6 (2013): 2571-2578.
Chicago
Zhang, L., Wang, H., Ji, X., Cong, Z., Zhu, J., Zhou, Y."FTY720 for cancer therapy (Review)". Oncology Reports 30, no. 6 (2013): 2571-2578. https://doi.org/10.3892/or.2013.2765
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