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2014-January Volume 31 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Role of fibulin-3 in lung cancer: In vivo and in vitro analyses

  • Authors:
    • Shun Xu
    • Yong Yang
    • Yan-Bin Sun
    • Hao-You Wang
    • Chang-Bo Sun
    • Xin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China, Sujiatun Center Hospital, Shenyang, Liaoning, P.R. China
  • Pages: 79-86
    |
    Published online on: October 18, 2013
       https://doi.org/10.3892/or.2013.2799
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Abstract

Lung cancer was the most commonly diagnosed cancer in 2008 worldwide. The level of fibulin-3 expression was found to be decreased in many cancer types due to aberrant promoter methylation and is correlated with poor survival of patients. However, the role of fibulin-3 and which form of fibulin-3 is expressed in lung cancer cells remain unclear. Therefore, pathologic and functional studies were carried out to determine the role of fibulin-3 in suppressing lung cancer both in vivo and in vitro. In the present study, we found that the levels of fibulin-3 mRNA and protein were lower in cancer tissues than in normal tissues. Downregulation of fibulin-3 mRNA in tumor tissues was associated with an increase in fibulin-3 promoter methylation. Circulating fibulin-3 was significantly associated with tumor progression, survival rate of lung cancer patients, and the number of circulating tumor cells (CTCs). To examine the effects of exogenous expression of fibulin-3 in vitro, lung cancer A549 cells were transfected with the pEGFP-C1-fibulin-3 expression vector. Relative to the untreated cells, fibulin-3-expressing cells exhibited lower proliferation and mobility as determined by MTT and Transwell assays, respectively. To conclude, our results suggest that fibulin-3 negatively modulates the invasiveness of lung cancer cells via regulation of p38-MAPK and MMP-2/9.
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Copy and paste a formatted citation
Spandidos Publications style
Xu S, Yang Y, Sun Y, Wang H, Sun C and Zhang X: Role of fibulin-3 in lung cancer: In vivo and in vitro analyses. Oncol Rep 31: 79-86, 2014.
APA
Xu, S., Yang, Y., Sun, Y., Wang, H., Sun, C., & Zhang, X. (2014). Role of fibulin-3 in lung cancer: In vivo and in vitro analyses. Oncology Reports, 31, 79-86. https://doi.org/10.3892/or.2013.2799
MLA
Xu, S., Yang, Y., Sun, Y., Wang, H., Sun, C., Zhang, X."Role of fibulin-3 in lung cancer: In vivo and in vitro analyses". Oncology Reports 31.1 (2014): 79-86.
Chicago
Xu, S., Yang, Y., Sun, Y., Wang, H., Sun, C., Zhang, X."Role of fibulin-3 in lung cancer: In vivo and in vitro analyses". Oncology Reports 31, no. 1 (2014): 79-86. https://doi.org/10.3892/or.2013.2799
Copy and paste a formatted citation
x
Spandidos Publications style
Xu S, Yang Y, Sun Y, Wang H, Sun C and Zhang X: Role of fibulin-3 in lung cancer: In vivo and in vitro analyses. Oncol Rep 31: 79-86, 2014.
APA
Xu, S., Yang, Y., Sun, Y., Wang, H., Sun, C., & Zhang, X. (2014). Role of fibulin-3 in lung cancer: In vivo and in vitro analyses. Oncology Reports, 31, 79-86. https://doi.org/10.3892/or.2013.2799
MLA
Xu, S., Yang, Y., Sun, Y., Wang, H., Sun, C., Zhang, X."Role of fibulin-3 in lung cancer: In vivo and in vitro analyses". Oncology Reports 31.1 (2014): 79-86.
Chicago
Xu, S., Yang, Y., Sun, Y., Wang, H., Sun, C., Zhang, X."Role of fibulin-3 in lung cancer: In vivo and in vitro analyses". Oncology Reports 31, no. 1 (2014): 79-86. https://doi.org/10.3892/or.2013.2799
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