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Article

Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression

  • Authors:
    • Aeyung Kim
    • Nam-Hui Yim
    • Minju Im
    • Young Pil Jung
    • Taesoo Kim
    • Jin Yeul Ma
  • View Affiliations / Copyright

    Affiliations: Korean Medicine (KM)-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine (KIOM), Daejeon 305-811, Republic of Korea
  • Pages: 287-297
    |
    Published online on: October 25, 2013
       https://doi.org/10.3892/or.2013.2822
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Abstract

KIOM-C, a novel herbal formula, was recently reported to be effective for treating pigs suffering from porcine circovirus-associated disease (PCVAD). In addition, administration of KIOM-C promoted clearance of influenza virus via production of antiviral cytokines, such as TNF-α and IFN-γ. Since metastasis is the major cause of cancer-related death and the greatest challenge in cancer treatment, we investigated the effect of KIOM-C on the metastatic potential of HT1080 and B16F10 cells. We observed inhibitory properties of KIOM-C in colony-forming activity, migration and invasion. Matrix metalloproteinase-9 (MMP-9) activity in the resting and PMA-stimulated state in HT1080 cells was dose-dependently decreased by KIOM-C treatment via suppression of NF-κB activation. In addition, daily oral administration of KIOM-C at doses of 170 and 510 mg/kg, the corresponding human adult daily doses, efficiently blocked lung metastasis in C57BL/6J mice following injection of B16F10 cells in the tail veins. In particular, none of the mice administered KIOM-C during the experimental period exhibited systemic toxicity, such as body weight loss or liver and kidney dysfunction. Collectively, our results suggest that KIOM-C is a potential therapeutic formula useful as a safe herbal medicine for controlling metastatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Kim A, Yim N, Im M, Jung YP, Kim T and Ma JY: Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression. Oncol Rep 31: 287-297, 2014.
APA
Kim, A., Yim, N., Im, M., Jung, Y.P., Kim, T., & Ma, J.Y. (2014). Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression. Oncology Reports, 31, 287-297. https://doi.org/10.3892/or.2013.2822
MLA
Kim, A., Yim, N., Im, M., Jung, Y. P., Kim, T., Ma, J. Y."Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression". Oncology Reports 31.1 (2014): 287-297.
Chicago
Kim, A., Yim, N., Im, M., Jung, Y. P., Kim, T., Ma, J. Y."Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression". Oncology Reports 31, no. 1 (2014): 287-297. https://doi.org/10.3892/or.2013.2822
Copy and paste a formatted citation
x
Spandidos Publications style
Kim A, Yim N, Im M, Jung YP, Kim T and Ma JY: Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression. Oncol Rep 31: 287-297, 2014.
APA
Kim, A., Yim, N., Im, M., Jung, Y.P., Kim, T., & Ma, J.Y. (2014). Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression. Oncology Reports, 31, 287-297. https://doi.org/10.3892/or.2013.2822
MLA
Kim, A., Yim, N., Im, M., Jung, Y. P., Kim, T., Ma, J. Y."Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression". Oncology Reports 31.1 (2014): 287-297.
Chicago
Kim, A., Yim, N., Im, M., Jung, Y. P., Kim, T., Ma, J. Y."Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression". Oncology Reports 31, no. 1 (2014): 287-297. https://doi.org/10.3892/or.2013.2822
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