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Article

Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma

  • Authors:
    • Hiroki Nishikawa
    • Yukio Osaki
    • Ryuichi Kita
    • Toru Kimura
    • Yoshiaki Ohara
    • Haruhiko Takeda
    • Azusa Sakamoto
    • Sumio Saito
    • Norihiro Nishijima
    • Akihiro Nasu
    • Hideyuki Komekado
    • Shuhei Nishiguchi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan, Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya 663-8501, Japan
  • Pages: 65-72
    |
    Published online on: November 13, 2013
       https://doi.org/10.3892/or.2013.2845
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Abstract

The aim of the present study was to compare clinical outcomes in patients with intermediate-stage hepatocellular carcinoma (HCC) who underwent the following treatments: transcatheter arterial chemoembolization (TACE) using an epirubicin-mitomycin-lipiodol (EML) emulsion at initial therapy (TACE group; n=145), and transcatheter chemotherapy infusion (TACI) using an EML emulsion at initial therapy (TACI group; n=81). Overall survival (OS) and treatment efficacy in the TACE and TACI groups were retrospectively compared. Prognostic factors associated with OS were examined using univariate and multivariate analyses. Treatment-related mortality was also calculated. The median observation periods were 1.8 years (range, 0.2-9.0 years) in the TACE group and 2.0 years (range, 0.2-8.7 years) in the TACI group. The median survival time and the 1-, 2-, 3- and 5-year cumulative OS rates were 2.68 years and 81.5, 63.4, 43.9 and 32.7%, respectively, in the TACE group, and 2.64 years and 85.0, 60.0, 43.2 and 26.0%, respectively, in the TACI group (P=0.691). The objective response rate was significantly higher in the TACE group compared to the TACI group (80.0 vs. 66.7%; P=0.009). Using multivariate analysis, the Child-Pugh classification (P=0.017), tumor number ≤5 (P=0.045) and des-γ-carboxy prothrombin level >100 mAU/ml (P=0.002) were found to be significant predictors linked to OS. In all subgroup analyses involving Child-Pugh classification, maximum tumor size and tumor distribution, the differences in the two groups did not reach statistical significance in terms of OS. Treatment mortality was 0% in the two groups. In conclusion, patients with intermediate-stage HCC had a comparable prognosis when treated with TACI or TACE.
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Copy and paste a formatted citation
Spandidos Publications style
Nishikawa H, Osaki Y, Kita R, Kimura T, Ohara Y, Takeda H, Sakamoto A, Saito S, Nishijima N, Nasu A, Nasu A, et al: Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma. Oncol Rep 31: 65-72, 2014.
APA
Nishikawa, H., Osaki, Y., Kita, R., Kimura, T., Ohara, Y., Takeda, H. ... Nishiguchi, S. (2014). Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma. Oncology Reports, 31, 65-72. https://doi.org/10.3892/or.2013.2845
MLA
Nishikawa, H., Osaki, Y., Kita, R., Kimura, T., Ohara, Y., Takeda, H., Sakamoto, A., Saito, S., Nishijima, N., Nasu, A., Komekado, H., Nishiguchi, S."Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma". Oncology Reports 31.1 (2014): 65-72.
Chicago
Nishikawa, H., Osaki, Y., Kita, R., Kimura, T., Ohara, Y., Takeda, H., Sakamoto, A., Saito, S., Nishijima, N., Nasu, A., Komekado, H., Nishiguchi, S."Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma". Oncology Reports 31, no. 1 (2014): 65-72. https://doi.org/10.3892/or.2013.2845
Copy and paste a formatted citation
x
Spandidos Publications style
Nishikawa H, Osaki Y, Kita R, Kimura T, Ohara Y, Takeda H, Sakamoto A, Saito S, Nishijima N, Nasu A, Nasu A, et al: Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma. Oncol Rep 31: 65-72, 2014.
APA
Nishikawa, H., Osaki, Y., Kita, R., Kimura, T., Ohara, Y., Takeda, H. ... Nishiguchi, S. (2014). Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma. Oncology Reports, 31, 65-72. https://doi.org/10.3892/or.2013.2845
MLA
Nishikawa, H., Osaki, Y., Kita, R., Kimura, T., Ohara, Y., Takeda, H., Sakamoto, A., Saito, S., Nishijima, N., Nasu, A., Komekado, H., Nishiguchi, S."Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma". Oncology Reports 31.1 (2014): 65-72.
Chicago
Nishikawa, H., Osaki, Y., Kita, R., Kimura, T., Ohara, Y., Takeda, H., Sakamoto, A., Saito, S., Nishijima, N., Nasu, A., Komekado, H., Nishiguchi, S."Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma". Oncology Reports 31, no. 1 (2014): 65-72. https://doi.org/10.3892/or.2013.2845
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