miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies

  • Authors:
    • Xiaohui Xu
    • Xiaodong Yang
    • Gan Ru
    • Yong Wu
    • Shuyu Zhang
    • Chungen Xing
    • Yongyou Wu
    • Jianping Cao
  • View Affiliations

  • Published online on: November 15, 2013     https://doi.org/10.3892/or.2013.2854
  • Pages: 472-479
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Abstract

Digestive tumors have the highest incidence among all tumor types worldwide. miR-146a has been shown to play an important role in the development, apoptosis, invasion and metastasis of digestive tumors. Additionally, a miR-146a gene polymorphism has been associated with the risk of a variety of cancer types in the digestive system. Therefore, in order to investigate the correlation, a meta-analysis of reported data was conducted, for which we obtained 21 research studies concerning the association between the miR-146a gene polymorphism and digestive tumors. Odds ratio (OR) values and 95% confidence intervals (95% CI) were used to assess this association. We found that the miR-146a polymorphism rs2910164 might significantly increase the susceptibility of digestive tumors, in particular for esophageal cancer and colorectal cancers. Furthermore, the miR-146a polymorphism might significantly increase the risk of digestive tumors in Asians. However, no obvious correlation between the polymorphism and the risk for digestive tumors was found in Caucasians.
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2014-January
Volume 31 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xu X, Yang X, Ru G, Wu Y, Zhang S, Xing C, Wu Y and Cao J: miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies. Oncol Rep 31: 472-479, 2014
APA
Xu, X., Yang, X., Ru, G., Wu, Y., Zhang, S., Xing, C. ... Cao, J. (2014). miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies. Oncology Reports, 31, 472-479. https://doi.org/10.3892/or.2013.2854
MLA
Xu, X., Yang, X., Ru, G., Wu, Y., Zhang, S., Xing, C., Wu, Y., Cao, J."miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies". Oncology Reports 31.1 (2014): 472-479.
Chicago
Xu, X., Yang, X., Ru, G., Wu, Y., Zhang, S., Xing, C., Wu, Y., Cao, J."miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies". Oncology Reports 31, no. 1 (2014): 472-479. https://doi.org/10.3892/or.2013.2854