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Article

Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients

  • Authors:
    • Noriko Tada
    • Nelson H. Tsuno
    • Kazushige Kawai
    • Koji Murono
    • Takako Nirei
    • Soichiro Ishihara
    • Eiji Sunami
    • Joji Kitayama
    • Toshiaki Watanabe
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, University of Tokyo, Tokyo 113-0033, Japan
  • Pages: 463-471
    |
    Published online on: November 19, 2013
       https://doi.org/10.3892/or.2013.2857
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Abstract

In the present study, we aimed to characterize the predictive value of cytokines/chemokines in rectal cancer (RC) patients receiving chemoradiation therapy (CRT). Blood samples were obtained pre- and post-CRT from 35 patients with advanced RC, who received neoadjuvant CRT followed by surgery, and the correlation between plasma levels of cytokines/chemokines and the response to CRT was analyzed. The pre-CRT levels of soluble CD40-ligand (sCD40L) and the post-CRT levels of chemokine ligand-5 (CCL-5) were significantly associated with the depth of tumor invasion and with venous invasion. In addition, a significant decrease in sCD40L and CCL-5, as well as in platelet counts, was associated with a favorable response to CRT. A significant correlation between pre-CRT platelet counts and sCD40L was observed in patients with a favorable response. By contrast, higher post-CRT interleukin (IL)-6 was associated with a poor response. Platelets, immune system and cancer cells, cross-linked through various cytokines/chemokines, appear to play an important role in the response to CRT, and by understanding their roles, new approaches for the improvement of the therapy might be proposed.
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Copy and paste a formatted citation
Spandidos Publications style
Tada N, Tsuno NH, Kawai K, Murono K, Nirei T, Ishihara S, Sunami E, Kitayama J and Watanabe T: Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients. Oncol Rep 31: 463-471, 2014.
APA
Tada, N., Tsuno, N.H., Kawai, K., Murono, K., Nirei, T., Ishihara, S. ... Watanabe, T. (2014). Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients. Oncology Reports, 31, 463-471. https://doi.org/10.3892/or.2013.2857
MLA
Tada, N., Tsuno, N. H., Kawai, K., Murono, K., Nirei, T., Ishihara, S., Sunami, E., Kitayama, J., Watanabe, T."Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients". Oncology Reports 31.1 (2014): 463-471.
Chicago
Tada, N., Tsuno, N. H., Kawai, K., Murono, K., Nirei, T., Ishihara, S., Sunami, E., Kitayama, J., Watanabe, T."Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients". Oncology Reports 31, no. 1 (2014): 463-471. https://doi.org/10.3892/or.2013.2857
Copy and paste a formatted citation
x
Spandidos Publications style
Tada N, Tsuno NH, Kawai K, Murono K, Nirei T, Ishihara S, Sunami E, Kitayama J and Watanabe T: Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients. Oncol Rep 31: 463-471, 2014.
APA
Tada, N., Tsuno, N.H., Kawai, K., Murono, K., Nirei, T., Ishihara, S. ... Watanabe, T. (2014). Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients. Oncology Reports, 31, 463-471. https://doi.org/10.3892/or.2013.2857
MLA
Tada, N., Tsuno, N. H., Kawai, K., Murono, K., Nirei, T., Ishihara, S., Sunami, E., Kitayama, J., Watanabe, T."Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients". Oncology Reports 31.1 (2014): 463-471.
Chicago
Tada, N., Tsuno, N. H., Kawai, K., Murono, K., Nirei, T., Ishihara, S., Sunami, E., Kitayama, J., Watanabe, T."Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients". Oncology Reports 31, no. 1 (2014): 463-471. https://doi.org/10.3892/or.2013.2857
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