Impact of stereotactic body radiotherapy on colorectal cancer with distant metastases

Hiraki,Masayuki; Nishimura,Junichi; Ohtsuka,Masahisa; Shiomi,Hiroya; Uemura,Mamoru; Haraguchi,Naotsugu; Hata,Taishi; Hayashi,Taro; Takemasa,Ichiro; Mizushima,Tsunekazu; Isohashi,Fumiaki; Yoshioka,Yasuo; Ogawa,Kazuhiko; Doki,Yuichiro; Mori,Masaki; Yamamoto,Hirofumi

doi:10.3892/or.2013.2871

2014-February Volume 31 Issue 2

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2014-February Volume 31 Issue 2

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Article

Impact of stereotactic body radiotherapy on colorectal cancer with distant metastases

Authors:
- Masayuki Hiraki
- Junichi Nishimura
- Masahisa Ohtsuka
- Hiroya Shiomi
- Mamoru Uemura
- Naotsugu Haraguchi
- Taishi Hata
- Taro Hayashi
- Ichiro Takemasa
- Tsunekazu Mizushima
- Fumiaki Isohashi
- Yasuo Yoshioka
- Kazuhiko Ogawa
- Yuichiro Doki
- Masaki Mori
- Hirofumi Yamamoto
View Affiliations / Copyright

Affiliations: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan, Department of Radiation Oncology, Saito Yukoukai Hospital, Osaka 567-0085, Japan, Department of Surgical Oncology, Saito Yukoukai Hospital, Osaka 567-0085, Japan, Department of Radiation Oncology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Pages: 795-799
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Published online on: November 27, 2013

https://doi.org/10.3892/or.2013.2871
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Abstract

Stereotactic radiotherapy is a minimally invasive technique for delivering highly focused ionizing radiation with extreme precision. This technique was initially developed in neurosurgical practice and applied to extracranial lesions in the 1990s, and was termed stereotactic body radiotherapy (SBRT). Studies have reported that the resection of distant metastases from colorectal cancer (CRC) contributes to relatively long-term survival. However, the resection of pulmonary and liver metastases is not possible for various reasons. SBRT offers a therapeutic alternative to unresectable metastatic lesions. The present study describes three cases of distant metastasis from CRC that exhibited a complete response (CR) to SBRT. Case 1 is a 70-year-old man with recurrent liver metastases after surgery for rectal cancer with liver metastasis (S3: diameter 1.8 cm and volume 3.0 ml; S6: diameter 1.3 cm and volume 1.2 ml). Cases 2 and 3 were 65-year-old and 70-year-old men, respectively. Both patients had pulmonary metastasis after surgery for rectal and cecum cancer (Case 2: diameter 1.2 cm and volume 0.9 ml; Case 3: diameter 0.8 cm and volume 0.27 ml). All cases were moderately differentiated adenocarcinomas. No serious adverse side-effects were observed during the therapy. CR was obtained in all patients on the basis of computed tomography 15-33 months after radiotherapy. Our experience supports that SBRT is a safe and alternative technique for resection in patients with distant metastasis from CRC who have small metastatic tumor volume.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Impact of stereotactic body radiotherapy on colorectal cancer with distant metastases

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