Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
2014-February Volume 31 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-February Volume 31 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma

  • Authors:
    • Qin Ru
    • Xiang Tian
    • Yu-Xiang Wu
    • Ri-Hui Wu
    • Ming-Shan Pi
    • Chao-Ying Li
  • View Affiliations / Copyright

    Affiliations: Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan, Hubei 430056, P.R. China
  • Pages: 842-848
    |
    Published online on: November 27, 2013
       https://doi.org/10.3892/or.2013.2875
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Increasing evidence indicates that potassium (K+) channels play important roles in the growth and development of human cancer. In the present study, we investigated the contribution of and the mechanism by which K+ channels control the proliferation and tumor development of U87-MG human glioma cells. A variety of K+ channel blockers and openers were used to differentiate the critical subtype of K+ channels involved. The in vitro data demonstrated that selective blockers of voltage-gated K+ (KV) channels or ATP-sensitive K+ (KATP) channels significantly inhibited the proliferation of U87-MG cells, blocked the cell cycle at the G0/G1 phase and induced apoptosis. In the U87-MG xenograft model in nude mice, KV or KATP channel blockers markedly suppressed tumor growth in vivo. Furthermore, electrophysiological results showed that KV or KATP channel blockers inhibited KV/KATP channel currents as well as cell proliferation and tumor growth over the same concentration range. In contrast, iberiotoxin, a selective blocker of calcium-activated K+ channels, had no apparent effect on the cell proliferation, cell cycle or apoptosis of U87-MG cells. In addition, the results of fluorescence assays indicated that blockers of KV or KATP channels attenuated intracellular Ca2+ signaling by blocking Ca2+ influx in U87-MG cells. Taken together, these data suggest that KV and KATP channels play important roles in the proliferation of U87-MG cells and that the influence of KV and KATP channels may be mediated by a Ca2+-dependent mechanism.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Ru Q, Shang BY, Miao QF, Li L, Wu SY, Gao RJ and Zhen YS: A cell penetrating peptide-integrated and enediyne-energized fusion protein shows potent antitumor activity. Eur J Pharm Sci. 47:781–789. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Van Meir EG, Hadjipanayis CG, Norden AD, Shu HK, Wen PY and Olson JJ: Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma. CA Cancer J Clin. 60:166–193. 2010.PubMed/NCBI

3 

Fiske JL, Fomin VP, Brown ML, Duncan RL and Sikes RA: Voltage-sensitive ion channels and cancer. Cancer Metastasis Rev. 25:493–500. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Spitzner M, Ousingsawat J, Scheidt K, Kunzelmann K and Schreiber R: Voltage-gated K+ channels support proliferation of colonic carcinoma cells. FASEB J. 21:35–44. 2007.

5 

Abdul M and Hoosein N: Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett. 186:99–105. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Zhang L, Zou W, Zhou SS and Chen DD: Potassium channels and proliferation and migration of breast cancer cells. Sheng Li Xue Bao. 61:15–20. 2009.PubMed/NCBI

7 

Le Guennec JY, Ouadid-Ahidouch H, Soriani O, Besson P, Ahidouch A and Vandier C: Voltage-gated ion channels, new targets in anti-cancer research. Recent Pat Anticancer Drug Discov. 2:189–202. 2007.PubMed/NCBI

8 

Huang L, Li B, Li W, Guo H and Zou F: ATP-sensitive potassium channels control glioma cell proliferation by regulating ERK activity. Carcinogenesis. 30:737–744. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Abdullaev IF, Rudkouskaya A, Mongin AA and Kuo YH: Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation. PLoS One. 5:e123042010. View Article : Google Scholar

10 

Lefranc F, Pouleau HB, Rynkowski M and De Witte O: Voltage-dependent K+ channels as oncotargets in malignant gliomas. Oncotarget. 3:516–517. 2012.

11 

Akamine T, Nishimura Y, Ito K, Uji Y and Yamamoto T: Effects of haloperidol on K+ currents in acutely isolated rat retinal ganglion cells. Invest Ophthalmol Vis Sci. 43:1257–1261. 2002.PubMed/NCBI

12 

Du Q, Jovanović S, Sukhodub A, Barratt E, Drew E, Whalley KM, Kay V, McLaughlin M, Telfer EE, Barratt CL and Jovanović A: Human oocytes express ATP-sensitive K+ channels. Hum Reprod. 25:2774–2782. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Yi CL, Liu YW, Xiong KM, Stewart RR, Peoples RW, Tian X, Zhou L, Ai YX, Li ZW, Wang QW and Li CY: Conserved extracellular cysteines differentially regulate the inhibitory effect of ethanol in rat P2X4 receptors. Biochem Biophys Res Commun. 381:102–106. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Schaarschmidt G, Wegner F, Schwarz SC, Schmidt H and Schwarz J: Characterization of voltage-gated potassium channels in human neural progenitor cells. PLoS One. 4:e61682009. View Article : Google Scholar : PubMed/NCBI

15 

Weaver AK, Liu X and Sontheimer H: Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells. J Neurosci Res. 78:224–234. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Pardo LA: Voltage-gated potassium channels in cell proliferation. Physiology. 19:285–292. 2004. View Article : Google Scholar : PubMed/NCBI

17 

DeCoursey TE, Chandy KG, Gupta S and Cahalan MD: Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature. 307:465–468. 1984.

18 

Pardo LA, Contreras-Jurado C, Zientkowska M, Alves F and Stühmer W: Role of voltage-gated potassium channels in cancer. J Membr Biol. 205:115–124. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Wang Z: Roles of K+ channels in regulating tumour cell proliferation and apoptosis. Pflugers Arch. 448:274–286. 2004.

20 

Elso CM, Lu X, Culiat CT, Rutledge JC, Cacheiro NL, Generoso WM and Stubbs LJ: Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice. Hum Mol Genet. 13:2813–2821. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Patel AJ and Lazdunski M: The 2P-domain K+ channels: role in apoptosis and tumorigenesis. Pflugers Arch. 448:261–273. 2004.

22 

Klimatcheva E and Wonderlin WF: An ATP-sensitive K+ current that regulates progression through early G1 phase of the cell cycle in MCF-7 human breast cancer cells. J Membr Biol. 171:35–46. 1999.

23 

Asher V, Warren A, Shaw R, Sowter H, Bali A and Khan R: The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. Cancer Cell Int. 11:62011. View Article : Google Scholar : PubMed/NCBI

24 

Zhanping W, Xiaoyu P, Na C, Shenglan W and Bo W: Voltage-gated K+ channels are associated with cell proliferation and cell cycle of ovarian cancer cell. Gynecol Oncol. 104:455–460. 2007.

25 

Yao X and Kwan HY: Activity of voltage-gated K+ channels is associated with cell proliferation and Ca2+ influx in carcinoma cells of colon cancer. Life Sci. 65:55–62. 1999.

26 

Shen Z, Yang Q and You Q: Research toward potassium channels on tumor progressions. Curr Top Med Chem. 9:322–329. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Jones RD, Kerr DJ, Harnett AN, Rankin EM, Ray S and Kaye SB: A pilot study of quinidine and epirubicin in the treatment of advanced breast cancer. Br J Cancer. 62:133–135. 1990. View Article : Google Scholar : PubMed/NCBI

28 

Fishman MC and Spector I: Potassium current suppression by quinidine reveals additional calcium currents in neuroblastoma cells. Proc Natl Acad Sci USA. 78:5245–5249. 1981. View Article : Google Scholar

29 

Basrai D, Kraft R, Bollensdorff C, Liebmann L, Benndorf K and Patt S: BK channel blockers inhibit potassium-induced proliferation of human astrocytoma cells. Neuroreport. 13:403–407. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Weiger TM, Colombatto S, Kainz V, Heidegger W, Grillo MA and Hermann A: Potassium channel blockers quinidine and caesium halt cell proliferation in C6 glioma cells via a polyamine-dependent mechanism. Biochem Soc Trans. 35:391–395. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ru Q, Tian X, Wu Y, Wu R, Pi M and Li C: Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma. Oncol Rep 31: 842-848, 2014.
APA
Ru, Q., Tian, X., Wu, Y., Wu, R., Pi, M., & Li, C. (2014). Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma. Oncology Reports, 31, 842-848. https://doi.org/10.3892/or.2013.2875
MLA
Ru, Q., Tian, X., Wu, Y., Wu, R., Pi, M., Li, C."Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma". Oncology Reports 31.2 (2014): 842-848.
Chicago
Ru, Q., Tian, X., Wu, Y., Wu, R., Pi, M., Li, C."Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma". Oncology Reports 31, no. 2 (2014): 842-848. https://doi.org/10.3892/or.2013.2875
Copy and paste a formatted citation
x
Spandidos Publications style
Ru Q, Tian X, Wu Y, Wu R, Pi M and Li C: Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma. Oncol Rep 31: 842-848, 2014.
APA
Ru, Q., Tian, X., Wu, Y., Wu, R., Pi, M., & Li, C. (2014). Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma. Oncology Reports, 31, 842-848. https://doi.org/10.3892/or.2013.2875
MLA
Ru, Q., Tian, X., Wu, Y., Wu, R., Pi, M., Li, C."Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma". Oncology Reports 31.2 (2014): 842-848.
Chicago
Ru, Q., Tian, X., Wu, Y., Wu, R., Pi, M., Li, C."Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma". Oncology Reports 31, no. 2 (2014): 842-848. https://doi.org/10.3892/or.2013.2875
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team