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Article

Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer

  • Authors:
    • Kunihiko Izuishi
    • Yuka Yamamoto
    • Hirohito Mori
    • Riko Kameyama
    • Shintaro Fujihara
    • Tsutomu Masaki
    • Yasuyuki Suzuki
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, Miki, Kita, Kagawa 761-0793, Japan, Department of Radiology, Faculty of Medicine, Kagawa University, Miki, Kita, Kagawa 761-0793, Japan, Department of Internal Medicine of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kita, Kagawa 761-0793, Japan
  • Pages: 701-706
    |
    Published online on: November 29, 2013
       https://doi.org/10.3892/or.2013.2886
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Abstract

To elucidate the molecular mechanisms underlying the insufficient sensitivity in the detection of hepatocellular carcinoma (HCC) by [18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET), the characteristics of glucose metabolism-related protein expression in HCC were examined in liver metastasis from colorectal cancer (Meta). Thirty-four patients (14 Meta and 20 HCC) who underwent FDG-PET and hepatectomy were studied. The relationships between the maximum standardized uptake value (SUV) in tumors and the mRNA expression of glucose metabolism-related proteins [hexokinase (HK), glucose transporter 1 (GLUT1), and glucose-6-phosphatase (G6Pase)] and proliferating cell nuclear antigen (PCNA) were examined in snap-frozen specimens with quantitative PCR. Tumor detection rates were lower in HCC (15/20) compared to Meta (13/14) patients. HK and GLUT1 expression was lower and G6Pase expression was higher in HCC compared to Meta. In particular, GLUT1 overexpression was 92-fold in Meta and 11-fold in HCC compared to the surrounding liver. The SUV correlated with GLUT1 and PCNA expression in HCC, but not Meta patients. Of note, four cases of poorly differentiated (P/D) HCC compared to moderately differentiated (M/D) HCC produced completely different results for FDG uptake (SUV, 14.4 vs. 4.0) and mRNA expression (G6Pase expression, 0.007 vs. 1.5). Variations in the expression of glucose metabolism-related enzymes between HCC and Meta patients are attributed to origin or degree of differentiation. Low FDG uptake in M/D HCC reflected low GLUT1 and high G6Pase expression, while high FDG accumulation in P/D HCC could reflect increased GLUT1 and decreased G6Pase expression. These results may explain why M/D HCC is not detected as sensitively by FDG-PET.
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Copy and paste a formatted citation
Spandidos Publications style
Izuishi K, Yamamoto Y, Mori H, Kameyama R, Fujihara S, Masaki T and Suzuki Y: Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer. Oncol Rep 31: 701-706, 2014.
APA
Izuishi, K., Yamamoto, Y., Mori, H., Kameyama, R., Fujihara, S., Masaki, T., & Suzuki, Y. (2014). Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer. Oncology Reports, 31, 701-706. https://doi.org/10.3892/or.2013.2886
MLA
Izuishi, K., Yamamoto, Y., Mori, H., Kameyama, R., Fujihara, S., Masaki, T., Suzuki, Y."Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer". Oncology Reports 31.2 (2014): 701-706.
Chicago
Izuishi, K., Yamamoto, Y., Mori, H., Kameyama, R., Fujihara, S., Masaki, T., Suzuki, Y."Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer". Oncology Reports 31, no. 2 (2014): 701-706. https://doi.org/10.3892/or.2013.2886
Copy and paste a formatted citation
x
Spandidos Publications style
Izuishi K, Yamamoto Y, Mori H, Kameyama R, Fujihara S, Masaki T and Suzuki Y: Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer. Oncol Rep 31: 701-706, 2014.
APA
Izuishi, K., Yamamoto, Y., Mori, H., Kameyama, R., Fujihara, S., Masaki, T., & Suzuki, Y. (2014). Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer. Oncology Reports, 31, 701-706. https://doi.org/10.3892/or.2013.2886
MLA
Izuishi, K., Yamamoto, Y., Mori, H., Kameyama, R., Fujihara, S., Masaki, T., Suzuki, Y."Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer". Oncology Reports 31.2 (2014): 701-706.
Chicago
Izuishi, K., Yamamoto, Y., Mori, H., Kameyama, R., Fujihara, S., Masaki, T., Suzuki, Y."Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer". Oncology Reports 31, no. 2 (2014): 701-706. https://doi.org/10.3892/or.2013.2886
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