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Article

Upregulation of NEK2 is associated with drug resistance in ovarian cancer

  • Authors:
    • Xia Liu
    • Yutao Gao
    • Yi Lu
    • Jian Zhang
    • Li Li
    • Fuqiang Yin
  • View Affiliations / Copyright

    Affiliations: Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University, Chaoyang, Beijing 100020, P.R. China, Medical Scientific Research Centre, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
  • Pages: 745-754
    |
    Published online on: December 9, 2013
       https://doi.org/10.3892/or.2013.2910
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Abstract

NEK2 [NIMA (never in mitosis gene A)-related expressed kinase 2] is associated with various biological behaviors in the development of cancer, while research concerning its association with drug resistance is limited. The association of NEK2 with drug resistance in ovarian cancer has not yet been reported. In the present study, on the basis of microarray results from Oncomine and the GEO Profiles online database, we revealed that NEK2 mRNA expression in ovarian cancer tissues is upregulated. In addition, its expression in drug-resistant ovarian cancer cells was upregulated when compared with expression with their sensitive or parental counterparts. Finally, we performed a comprehensive bioinformatic analysis consisting of protein/gene-protein/gene interaction network, annotation of biological processes and microRNA-mRNA interaction analysis. We observed that NEK2 directly or indirectly interacts with a number of genes, proteins, microRNAs and biological processes associated with drug resistance in ovarian and other types of cancer. These results indicate that NEK2 contributes to drug resistance in ovarian cancer and it may be an important therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Gao Y, Lu Y, Zhang J, Li L and Yin F: Upregulation of NEK2 is associated with drug resistance in ovarian cancer. Oncol Rep 31: 745-754, 2014.
APA
Liu, X., Gao, Y., Lu, Y., Zhang, J., Li, L., & Yin, F. (2014). Upregulation of NEK2 is associated with drug resistance in ovarian cancer. Oncology Reports, 31, 745-754. https://doi.org/10.3892/or.2013.2910
MLA
Liu, X., Gao, Y., Lu, Y., Zhang, J., Li, L., Yin, F."Upregulation of NEK2 is associated with drug resistance in ovarian cancer". Oncology Reports 31.2 (2014): 745-754.
Chicago
Liu, X., Gao, Y., Lu, Y., Zhang, J., Li, L., Yin, F."Upregulation of NEK2 is associated with drug resistance in ovarian cancer". Oncology Reports 31, no. 2 (2014): 745-754. https://doi.org/10.3892/or.2013.2910
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Gao Y, Lu Y, Zhang J, Li L and Yin F: Upregulation of NEK2 is associated with drug resistance in ovarian cancer. Oncol Rep 31: 745-754, 2014.
APA
Liu, X., Gao, Y., Lu, Y., Zhang, J., Li, L., & Yin, F. (2014). Upregulation of NEK2 is associated with drug resistance in ovarian cancer. Oncology Reports, 31, 745-754. https://doi.org/10.3892/or.2013.2910
MLA
Liu, X., Gao, Y., Lu, Y., Zhang, J., Li, L., Yin, F."Upregulation of NEK2 is associated with drug resistance in ovarian cancer". Oncology Reports 31.2 (2014): 745-754.
Chicago
Liu, X., Gao, Y., Lu, Y., Zhang, J., Li, L., Yin, F."Upregulation of NEK2 is associated with drug resistance in ovarian cancer". Oncology Reports 31, no. 2 (2014): 745-754. https://doi.org/10.3892/or.2013.2910
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