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Article

Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway

  • Authors:
    • Yu-Chao Ma
    • Cui Li
    • Feng Gao
    • Yan Xu
    • Zhi-Bin Jiang
    • Jian-Xin Liu
    • Long-Yu Jin
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, The Third Xiangya Hospital, Central South University, Changsha 410013, P.R. China, Key Laboratory of Cancer Proteomics of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, P.R. China, Department of Ultrasound, The Third Xiangya Hospital, Central South University, Changsha 410013, P.R. China
  • Pages: 1343-1349
    |
    Published online on: December 19, 2013
       https://doi.org/10.3892/or.2013.2933
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Abstract

Epigallocatechin gallate (EGCG), the major biologically active compound in green tea, is a well-known chemoprevention agent. Although several reports have shown that EGCG exerts its anticancer activity by targeting specific cell signaling pathways, the underlying molecular mechanism(s) are only partially understood. In the present study, we report that EGCG had a profound antiproliferative effect on human lung cancer cells. EGCG inhibited anchorage-independent growth and induced cell cycle G0/G1 phase arrest. The mechanism underlying EGCG antitumor potency was mainly dependent on suppression of the EGFR signaling pathway. Short-term EGCG exposure substantially decreased EGF-induced EGFR, AKT and ERK1/2 activation. Moreover, long-term EGCG treatment not only inhibited total and membranous EGFR expression, but also markedly attenuated EGFR nuclear localization and expression of the downstream target gene cyclin D1, indicating that EGCG treatment suppressed EGFR transactivation. Additionally, knockdown of EGFR in lung cancer cells decreased their sensitivity to EGCG. Thus, inhibition of the EGFR signaling pathway may partly contribute to the anticancer activity of EGCG.
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Copy and paste a formatted citation
Spandidos Publications style
Ma Y, Li C, Gao F, Xu Y, Jiang Z, Liu J and Jin L: Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway. Oncol Rep 31: 1343-1349, 2014.
APA
Ma, Y., Li, C., Gao, F., Xu, Y., Jiang, Z., Liu, J., & Jin, L. (2014). Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway. Oncology Reports, 31, 1343-1349. https://doi.org/10.3892/or.2013.2933
MLA
Ma, Y., Li, C., Gao, F., Xu, Y., Jiang, Z., Liu, J., Jin, L."Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway". Oncology Reports 31.3 (2014): 1343-1349.
Chicago
Ma, Y., Li, C., Gao, F., Xu, Y., Jiang, Z., Liu, J., Jin, L."Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway". Oncology Reports 31, no. 3 (2014): 1343-1349. https://doi.org/10.3892/or.2013.2933
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Y, Li C, Gao F, Xu Y, Jiang Z, Liu J and Jin L: Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway. Oncol Rep 31: 1343-1349, 2014.
APA
Ma, Y., Li, C., Gao, F., Xu, Y., Jiang, Z., Liu, J., & Jin, L. (2014). Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway. Oncology Reports, 31, 1343-1349. https://doi.org/10.3892/or.2013.2933
MLA
Ma, Y., Li, C., Gao, F., Xu, Y., Jiang, Z., Liu, J., Jin, L."Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway". Oncology Reports 31.3 (2014): 1343-1349.
Chicago
Ma, Y., Li, C., Gao, F., Xu, Y., Jiang, Z., Liu, J., Jin, L."Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway". Oncology Reports 31, no. 3 (2014): 1343-1349. https://doi.org/10.3892/or.2013.2933
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