|
1
|
Wu T: Cyclooxygenase-2 in hepatocellular
carcinoma. Cancer Treat Rev. 32:28–44. 2006. View Article : Google Scholar
|
|
2
|
Pang RW, Joh JW, Johnson PJ, Monden M,
Pawlik TM and Poon RT: Biology of hepatocellular carcinoma. Ann
Surg Oncol. 15:962–971. 2008. View Article : Google Scholar
|
|
3
|
Uchino K, Tateishi R, Shiina S, et al:
Hepatocellular carcinoma with extrahepatic metastasis: clinical
features and prognostic factors. Cancer. 117:4475–4483. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Bai XM, Zhang W, Liu NB, et al: Focal
adhesion kinase: Important to prostaglandin E2-mediated
adhesion, migration and invasion in hepatocellular carcinoma cells.
Oncol Rep. 21:129–136. 2009.PubMed/NCBI
|
|
5
|
Wu J, Zhang Y, Frilot N, Kim JI, Kim WJ
and Daaka Y: Prostaglandin E2 regulates renal cell
carcinoma invasion through the EP4 receptor-Rap GTPase signal
transduction pathway. J Biol Chem. 286:33954–33962. 2011.
|
|
6
|
Vo BT, Morton D Jr, Komaragiri S, Millena
AC, Leath C and Khan SA: TGF-β effects on prostate cancer cell
migration and invasion are mediated by PGE2 through
activation of PI3K/AKT/mTOR pathway. Endocrinology. 154:1768–1779.
2013.
|
|
7
|
Zhang L, Jiang L, Sun Q, et al:
Prostaglandin E2 enhances mitogen-activated protein kinase/Erk
pathway in human cholangiocarcinoma cells: involvement of EP1
receptor, calcium and EGF receptors signaling. Mol Cell Biochem.
305:19–26. 2007. View Article : Google Scholar
|
|
8
|
Han C, Michalopoulos GK and Wu T:
Prostaglandin E2 receptor EP1 transactivates EGFR/MET
receptor tyrosine kinases and enhances invasiveness in human
hepatocellular carcinoma cells. J Cell Physiol. 207:261–270.
2006.
|
|
9
|
Breyer RM, Bagdassarian CK, Myers SA and
Breyer MD: Prostanoid receptors: subtypes and signaling. Annu Rev
Pharmacol Toxicol. 41:661–690. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Bos CL, Richel DJ, Ritsema T,
Peppelenbosch MP and Versteeg HH: Prostanoids and prostanoid
receptors in signal transduction. Int J Biochem Cell Biol.
36:1187–1205. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Jiang J and Dingledine R: Role of
prostaglandin receptor EP2 in the regulations of cancer cell
proliferation, invasion, and inflammation. J Pharmacol Exp Ther.
344:360–367. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Pan MR, Hou MF, Chang HC and Hung WC:
Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling
pathways to enhance lymphatic invasion of breast cancer cells. J
Biol Chem. 283:11155–11163. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wang X and Klein RD: Prostaglandin E2
induces vascular endothelial growth factor secretion in prostate
cancer cells through EP2 receptor-mediated cAMP pathway. Mol
Carcinog. 46:912–923. 2007. View
Article : Google Scholar : PubMed/NCBI
|
|
14
|
Guarino M, Rubino B and Ballabio G: The
role of epithelial-mesenchymal transition in cancer pathology.
Pathology. 39:305–318. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Fan F, Samuel S, Evans KW, et al:
Overexpression of snail induces epithelial-mesenchymal transition
and a cancer stem cell-like phenotype in human colorectal cancer
cells. Cancer Med. 1:5–16. 2013. View
Article : Google Scholar : PubMed/NCBI
|
|
16
|
Wang Y, Shi J, Chai K, Ying X and Zhou BP:
The role of Snail in EMT and tumorigenesis. Curr Cancer Drug
Targets. 13:963–972. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Emadi Baygi M, Soheili ZS, Schmitz I,
Sameie S and Schulz WA: Snail regulates cell survival and inhibits
cellular senescence in human metastatic prostate cancer cell lines.
Cell Biol Toxicol. 26:553–567. 2010.PubMed/NCBI
|
|
18
|
Nishioka R, Itoh S, Gui T, et al: SNAIL
induces epithelial-to-mesenchymal transition in a human pancreatic
cancer cell line (BxPC3) and promotes distant metastasis and
invasiveness in vivo. Exp Mol Pathol. 89:149–157. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Haslehurst AM, Koti M, Dharsee M, et al:
EMT transcription factors snail and slug directly contribute to
cisplatin resistance in ovarian cancer. BMC Cancer. 12:912012.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Wang H, Wang HS, Zhou BH, et al:
Epithelial-mesenchymal transition (EMT) induced by TNF-α requires
AKT/GSK-3β-mediated stabilization of snail in colorectal cancer.
PLoS One. 8:e566642013.
|
|
21
|
He H, Chen W, Wang X, et al: Snail is an
independent prognostic predictor for progression and patient
survival of gastric cancer. Cancer Sci. 103:1296–1303. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Han C, Demetris AJ, Michalopoulos G,
Shelhamer JH and Wu T: 85-kDa cPLA2 plays a critical
role in PPAR-mediated gene transcription in human hepatoma cells.
Am J Physiol Gastrointest Liver Physiol. 282:G586–G597.
2002.PubMed/NCBI
|
|
23
|
Rahman MA, Dhar DK, Yamaguchi E, et al:
Coexpression of inducible nitric oxide synthase and COX-2 in
hepatocellular carcinoma and surrounding liver: possible
involvement of COX-2 in the angiogenesis of hepatitis C
virus-positive cases. Clin Cancer Res. 7:1325–1332. 2001.
|
|
24
|
Li T, Zhu Y, Ren W, et al: High
co-expression of vascular endothelial growth factor receptor-1 and
Snail is associated with poor prognosis after curative resection of
hepatocellular carcinoma. Med Oncol. 29:2750–2761. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Tang TC, Poon RT, Lau CP, Xie D and Fan
ST: Tumor cyclooxygenase-2 levels correlate with tumor invasiveness
in human hepatocellular carcinoma. World J Gastroenterol.
11:1896–1902. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Koga H: Hepatocellular carcinoma: is there
a potential for chemoprevention using cyclooxygenase-2 inhibitors?
Cancer. 98:661–667. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Bai XM, Jiang H, Ding JX, et al:
Prostaglandin E2 upregulates survivin expression via the
EP1 receptor in hepatocellular carcinoma cells. Life Sci.
86:214–223. 2009.
|
|
28
|
Ma J, Chen M, Xia SK, et al: Prostaglandin
E2 promotes liver cancer cell growth by the upregulation
of FUSE-binding protein 1 expression. Int J Oncol. 42:1093–1104.
2013.
|
|
29
|
Mayoral R, Fernandez-Martinez A, Bosca L
and Martin-Sanz P: Prostaglandin E2 promotes migration
and adhesion in hepatocellular carcinoma cells. Carcinogenesis.
26:753–761. 2005.PubMed/NCBI
|
|
30
|
Sheng H, Shao J, Washington MK and DuBois
RN: Prostaglandin E2 increases growth and motility of
colorectal carcinoma cells. J Biol Chem. 276:18075–18081.
2001.PubMed/NCBI
|
|
31
|
Breyer MD and Breyer RM: G protein-coupled
prostanoid receptors and the kidney. Annu Rev Physiol. 63:579–605.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Boie Y, Stocco R, Sawyer N, et al:
Molecular cloning and characterization of the four rat
prostaglandin E2 prostanoid receptor subtypes. Eur J
Pharmacol. 340:227–241. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Regan JW: EP2 and
EP4 prostanoid receptor signaling. Life Sci. 74:143–153.
2003.
|
|
34
|
Sanchez-Tillo E, Liu Y, de Barrios O, et
al: EMT-activating transcription factors in cancer: beyond EMT and
tumor invasiveness. Cell Mol Life Sci. 69:3429–3456. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Blechschmidt K, Kremmer E, Hollweck R, et
al: The E-cadherin repressor snail plays a role in tumor
progression of endometrioid adenocarcinomas. Diagn Mol Pathol.
16:222–228. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Guaita S, Puig I, Franci C, et al: Snail
induction of epithelial to mesenchymal transition in tumor cells is
accompanied by MUC1 repression and ZEB1 expression. J Biol Chem.
277:39209–39216. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Miyoshi A, Kitajima Y, Sumi K, et al:
Snail and SIP1 increase cancer invasion by upregulating MMP family
in hepatocellular carcinoma cells. Br J Cancer. 90:1265–1273. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Miyoshi A, Kitajima Y, Kido S, et al:
Snail accelerates cancer invasion by upregulating MMP expression
and is associated with poor prognosis of hepatocellular carcinoma.
Br J Cancer. 92:252–258. 2005.PubMed/NCBI
|
|
39
|
Mikami S, Katsube K, Oya M, et al:
Expression of Snail and Slug in renal cell carcinoma: E-cadherin
repressor Snail is associated with cancer invasion and prognosis.
Lab Invest. 91:1443–1458. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Dohadwala M, Yang SC, Luo J, et al:
Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin
E2 induces transcriptional repressors ZEB1 and snail in
non-small cell lung cancer. Cancer Res. 66:5338–5345. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Kuo KT, Wang HW, Chou TY, et al:
Prognostic role of PGE2 receptor EP2 in esophageal squamous cell
carcinoma. Ann Surg Oncol. 16:352–360. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Buchanan FG and DuBois RN: Emerging roles
of β-arrestins. Cell Cycle. 5:2060–2063. 2006.
|
|
43
|
Fischer OM, Hart S, Gschwind A and Ullrich
A: EGFR signal transactivation in cancer cells. Biochem Soc Trans.
31:1203–1208. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Hipp S, Walch A, Schuster T, et al:
Activation of epidermal growth factor receptor results in snail
protein but not mRNA overexpression in endometrial cancer. J Cell
Mol Med. 13:3858–3867. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Yun SP, Ryu JM, Jang MW and Han HJ:
Interaction of profilin-1 and F-actin via a β-arrestin-1/JNK
signaling pathway involved in prostaglandin E2-induced
human mesenchymal stem cells migration and proliferation. J Cell
Physiol. 226:559–571. 2010.
|
|
46
|
Donnini S, Finetti F, Solito R, et al: EP2
prostanoid receptor promotes squamous cell carcinoma growth through
epidermal growth factor receptor transactivation and iNOS and
ERK1/2 pathways. FASEB J. 21:2418–2430. 2007. View Article : Google Scholar
|
|
47
|
Chun KS, Lao HC, Trempus CS, Okada M and
Langenbach R: The prostaglandin receptor EP2 activates multiple
signaling pathways and β-arrestin1 complex formation during mouse
skin papilloma development. Carcinogenesis. 30:1620–1627. 2009.
|
|
48
|
Ayuso-Sacido A, Moliterno JA, Kratovac S,
et al: Activated EGFR signaling increases proliferation, survival,
and migration and blocks neuronal differentiation in post-natal
neural stem cells. J Neurooncol. 97:323–337. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Glaysher S, Bolton LM, Johnson P, et al:
Targeting EGFR and PI3K pathways in ovarian cancer. Br J Cancer.
109:1786–1794. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Leng J, Han C, Demetris AJ, Michalopoulos
GK and Wu T: Cyclooxygenase-2 promotes hepatocellular carcinoma
cell growth through Akt activation: evidence for Akt inhibition in
celecoxib-induced apoptosis. Hepatology. 38:756–768. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Ogunwobi OO, Wang T, Zhang L and Liu C:
Cyclooxygenase-2 and Akt mediate multiple growth-factor-induced
epithelial-mesenchymal transition in human hepatocellular
carcinoma. J Gastroenterol Hepatol. 27:566–578. 2011. View Article : Google Scholar
|
|
52
|
Park MK, Kang YJ, Ha YM, et al: EP2
receptor activation by prostaglandin E2 leads to
induction of HO-1 via PKA and PI3K pathways in C6 cells. Biochem
Biophys Res Commun. 379:1043–1047. 2009.PubMed/NCBI
|
|
53
|
Fresno Vara JA, Casado E, de Castro J,
Cejas P, Belda-Iniesta C and Gonzalez-Baron M: PI3K/Akt signalling
pathway and cancer. Cancer Treat Rev. 30:193–204. 2004.PubMed/NCBI
|
|
54
|
Lau MT and Leung PC: The PI3K/Akt/mTOR
signaling pathway mediates insulin-like growth factor 1-induced
E-cadherin down-regulation and cell proliferation in ovarian cancer
cells. Cancer Lett. 326:191–198. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Hung CM, Garcia-Haro L, Sparks CA and
Guertin DA: mTOR-dependent cell survival mechanisms. Cold Spring
Harb Perspect Biol. 4:a0087712012.PubMed/NCBI
|
|
56
|
Garcia-Maceira P and Mateo J: Silibinin
inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1
signalling pathway in human cervical and hepatoma cancer cells:
implications for anticancer therapy. Oncogene. 28:313–324.
2009.
|
|
57
|
Vivanco I and Sawyers CL: The
phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev
Cancer. 2:489–501. 2002. View
Article : Google Scholar : PubMed/NCBI
|
