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Article

Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer

  • Authors:
    • Tao Bai
    • Dao-Song Dong
    • Ling Pei
  • View Affiliations / Copyright

    Affiliations: Department of Anaesthesiology, The First Hospital of China Medical University, Heping, Shenyang, Liaoning 110001, P.R. China
  • Pages: 2293-2297
    |
    Published online on: March 14, 2014
       https://doi.org/10.3892/or.2014.3090
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Abstract

microRNAs have emerged as promising molecular factors with potential for clinical applications in cancer diagnosis and therapy. In the present study, we demonstrated that the level of miR-200c in lung cancer tissues was lower than that in normal tissues using real-time PCR. To further investigate the effects of miR-200c expression in lung cancer cells, we upregulated miR-200c levels in H460 cells using transfection. We found that the percentage of apoptotic cells was higher in the cells expressing miR-200c than that in the untransfected cells. Furthermore, the antitumor activities of miR-200c were demonstrated in vivo. Notably, we confirmed that reservatol (RESV) showed stronger antitumor activities in miR-200c-positive cells than in miR-200c-negative cells. Finally, we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK, followed by activation of the JNK signaling pathway and ER stress. Collectively, these data show that miR-200c expression sensitizes H460 cells to RESV and this is likely due to RECK expression.
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Copy and paste a formatted citation
Spandidos Publications style
Bai T, Dong D and Pei L: Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer. Oncol Rep 31: 2293-2297, 2014.
APA
Bai, T., Dong, D., & Pei, L. (2014). Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer. Oncology Reports, 31, 2293-2297. https://doi.org/10.3892/or.2014.3090
MLA
Bai, T., Dong, D., Pei, L."Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer". Oncology Reports 31.5 (2014): 2293-2297.
Chicago
Bai, T., Dong, D., Pei, L."Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer". Oncology Reports 31, no. 5 (2014): 2293-2297. https://doi.org/10.3892/or.2014.3090
Copy and paste a formatted citation
x
Spandidos Publications style
Bai T, Dong D and Pei L: Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer. Oncol Rep 31: 2293-2297, 2014.
APA
Bai, T., Dong, D., & Pei, L. (2014). Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer. Oncology Reports, 31, 2293-2297. https://doi.org/10.3892/or.2014.3090
MLA
Bai, T., Dong, D., Pei, L."Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer". Oncology Reports 31.5 (2014): 2293-2297.
Chicago
Bai, T., Dong, D., Pei, L."Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer". Oncology Reports 31, no. 5 (2014): 2293-2297. https://doi.org/10.3892/or.2014.3090
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