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Article Open Access

Timing of cisplatin administration for chemoradiotherapy in transgenic mice bearing lens tumors

  • Authors:
    • Shoji Kaku
    • Norichika Ushioda
    • Hiroshi Ishii
    • Takashi Murakami
    • Kentaro Takahashi
    • Yuichiro Nakai
    • Koichiro Shimoya
    • Takafumi Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Kawasaki Medical School, Okayama, Japan, Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga, Japan
    Copyright: © Kaku et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 16-22
    |
    Published online on: May 20, 2014
       https://doi.org/10.3892/or.2014.3202
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Abstract

Cisplatin-based concurrent chemoradiotherapy (CCRT) has become a standard treatment for cancer of the uterine cervix. However, there have been no investigations into the optimum timing for administration of anticancer drugs using animal models. The aim of the present study was to determine the appropriate timing for administration of the anticancer drug cisplatin in relation to delivery of radiation by assessing the antitumor activity and adverse effects of 3 different regimens in αT3 transgenic mice bearing lens epithelial tumors. CCRT showed the strongest antitumor activity. There was a significant difference between CCRT and administration of cisplatin before radiotherapy (neoadjuvant therapy) with regard to the apoptotic effect detected by TUNEL staining, but there was no significant difference between CCRT and administration of cisplatin after radiotherapy (adjuvant therapy). Assessment of adverse effects showed that there were no significant differences in the mortality rate, weight loss, anemia and leukopenia among the 3 regimens. In conclusion, these findings obtained in an animal model suggest that cisplatin should probably not be administered before irradiation, since the antitumor effect is significantly weaker than that of CCRT or administration after irradiation, while adverse effects are similar.
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Copy and paste a formatted citation
Spandidos Publications style
Kaku S, Ushioda N, Ishii H, Murakami T, Takahashi K, Nakai Y, Shimoya K and Nakamura T: Timing of cisplatin administration for chemoradiotherapy in transgenic mice bearing lens tumors. Oncol Rep 32: 16-22, 2014.
APA
Kaku, S., Ushioda, N., Ishii, H., Murakami, T., Takahashi, K., Nakai, Y. ... Nakamura, T. (2014). Timing of cisplatin administration for chemoradiotherapy in transgenic mice bearing lens tumors. Oncology Reports, 32, 16-22. https://doi.org/10.3892/or.2014.3202
MLA
Kaku, S., Ushioda, N., Ishii, H., Murakami, T., Takahashi, K., Nakai, Y., Shimoya, K., Nakamura, T."Timing of cisplatin administration for chemoradiotherapy in transgenic mice bearing lens tumors". Oncology Reports 32.1 (2014): 16-22.
Chicago
Kaku, S., Ushioda, N., Ishii, H., Murakami, T., Takahashi, K., Nakai, Y., Shimoya, K., Nakamura, T."Timing of cisplatin administration for chemoradiotherapy in transgenic mice bearing lens tumors". Oncology Reports 32, no. 1 (2014): 16-22. https://doi.org/10.3892/or.2014.3202
Copy and paste a formatted citation
x
Spandidos Publications style
Kaku S, Ushioda N, Ishii H, Murakami T, Takahashi K, Nakai Y, Shimoya K and Nakamura T: Timing of cisplatin administration for chemoradiotherapy in transgenic mice bearing lens tumors. Oncol Rep 32: 16-22, 2014.
APA
Kaku, S., Ushioda, N., Ishii, H., Murakami, T., Takahashi, K., Nakai, Y. ... Nakamura, T. (2014). Timing of cisplatin administration for chemoradiotherapy in transgenic mice bearing lens tumors. Oncology Reports, 32, 16-22. https://doi.org/10.3892/or.2014.3202
MLA
Kaku, S., Ushioda, N., Ishii, H., Murakami, T., Takahashi, K., Nakai, Y., Shimoya, K., Nakamura, T."Timing of cisplatin administration for chemoradiotherapy in transgenic mice bearing lens tumors". Oncology Reports 32.1 (2014): 16-22.
Chicago
Kaku, S., Ushioda, N., Ishii, H., Murakami, T., Takahashi, K., Nakai, Y., Shimoya, K., Nakamura, T."Timing of cisplatin administration for chemoradiotherapy in transgenic mice bearing lens tumors". Oncology Reports 32, no. 1 (2014): 16-22. https://doi.org/10.3892/or.2014.3202
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