1
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: the next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
2
|
Warburg O: On respiratory impairment in
cancer cells. Science. 124:269–270. 1956.PubMed/NCBI
|
3
|
Warburg O: On the origin of cancer cells.
Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI
|
4
|
Warburg O, Wind F and Negelein E: The
metabolism of tumors in the body. J Gen Physiol. 8:519–530. 1927.
View Article : Google Scholar : PubMed/NCBI
|
5
|
Denko NC: Hypoxia, HIF1 and glucose
metabolism in the solid tumour. Nat Rev Cancer. 8:705–713. 2008.
View Article : Google Scholar : PubMed/NCBI
|
6
|
Mathew R, Karantza-Wadsworth V and White
E: Role of autophagy in cancer. Nat Rev Cancer. 7:961–967. 2007.
View Article : Google Scholar
|
7
|
Levine B: Cell biology: autophagy and
cancer. Nature. 446:745–747. 2007. View
Article : Google Scholar : PubMed/NCBI
|
8
|
Mizushima N: Autophagy: process and
function. Genes Dev. 21:2861–2873. 2007. View Article : Google Scholar
|
9
|
Degenhardt K, Mathew R, Beaudoin B, et al:
Autophagy promotes tumor cell survival and restricts necrosis,
inflammation, and tumorigenesis. Cancer Cell. 10:51–64. 2006.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Boya P, González-Polo RA, Casares N, et
al: Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol.
25:1025–1040. 2005. View Article : Google Scholar : PubMed/NCBI
|
11
|
Colell A, Ricci JE, Tait S, et al: GAPDH
and autophagy preserve survival after apoptotic cytochrome c
release in the absence of caspase activation. Cell. 129:983–997.
2007. View Article : Google Scholar : PubMed/NCBI
|
12
|
Karantza-Wadsworth V, Patel S, Kravchuk O,
et al: Autophagy mitigates metabolic stress and genome damage in
mammary tumorigenesis. Genes Dev. 21:1621–1635. 2007. View Article : Google Scholar : PubMed/NCBI
|
13
|
Kuma A, Hatano M, Matsui M, et al: The
role of autophagy during the early neonatal starvation period.
Nature. 432:1032–1036. 2004. View Article : Google Scholar : PubMed/NCBI
|
14
|
Onodera J and Ohsumi Y: Autophagy is
required for maintenance of amino acid levels and protein synthesis
under nitrogen starvation. J Biol Chem. 280:31582–31586. 2005.
View Article : Google Scholar : PubMed/NCBI
|
15
|
Zhang J, Yang Y, Yang T, et al:
microRNA-22, downregulated in hepatocellular carcinoma and
correlated with prognosis, suppresses cell proliferation and
tumourigenicity. Br J Cancer. 103:1215–1220. 2010. View Article : Google Scholar : PubMed/NCBI
|
16
|
Gasz B, Rácz B, Roth E, et al: Pituitary
adenylate cyclase activating polypeptide protects cardiomyocytes
against oxidative stress-induced apoptosis. Peptides. 27:87–94.
2006. View Article : Google Scholar
|
17
|
Gartlon J, Kinsner A, Bal-Price A, Coecke
S and Clothier RH: Evaluation of a proposed in vitro test strategy
using neuronal and non-neuronal cell systems for detecting
neurotoxicity. Toxicol In Vitro. 20:1569–1581. 2006. View Article : Google Scholar : PubMed/NCBI
|
18
|
Coleman MD, O’Neil JD, Woehrling EK, et
al: A preliminary investigation into the impact of a pesticide
combination on human neuronal and glial cell lines in vitro. PLoS
One. 7:e427682012. View Article : Google Scholar : PubMed/NCBI
|
19
|
Cappello C, Zwergal A, Kanclerski S, et
al: C/EBPβ enhances NF-κB-associated signalling by reducing the
level of IκB-α. Cell Signal. 21:1918–1924. 2009.
|
20
|
Venegas V, Wang J, Dimmock D and Wong LJ:
Real-time quantitative PCR analysis of mitochondrial DNA content.
Curr Protoc Hum Genet. Unit 19.17:2011.PubMed/NCBI
|
21
|
Pola C: Cancer microenvironment: p53 acts
in the hood. Nat Med. 19:5462013. View
Article : Google Scholar
|
22
|
Yermolaieva O, Xu R, Schinstock C, et al:
Methionine sulfoxide reductase A protects neuronal cells against
brief hypoxia/reoxygenation. Proc Natl Acad Sci USA. 101:1159–1164.
2004. View Article : Google Scholar : PubMed/NCBI
|
23
|
Finnegan NM, Curtin JF, Prevost G, Morgan
B and Cotter TG: Induction of apoptosis in prostate carcinoma cells
by BH3 peptides which inhibit Bak/Bcl-2 interactions. Br J Cancer.
85:115–121. 2001. View Article : Google Scholar : PubMed/NCBI
|
24
|
Hardwick JM and Soane L: Multiple
functions of BCL-2 family proteins. Cold Spring Harb Perspect Biol.
5:a0087222013. View Article : Google Scholar : PubMed/NCBI
|
25
|
Zhou F, Yang Y and Xing D: Bcl-2 and
Bcl-xL play important roles in the crosstalk between autophagy and
apoptosis. FEBS J. 278:403–413. 2011. View Article : Google Scholar : PubMed/NCBI
|
26
|
Kaira K, Oriuchi N, Takahashi T, et al:
LAT1 expression is closely associated with hypoxic markers and mTOR
in resected non-small cell lung cancer. Am J Transl Res. 3:468–478.
2011.PubMed/NCBI
|
27
|
Fukumoto S, Hanazono K, Komatsu T, Iwano
H, Kadosawa T and Uchide T: L-type amino acid transporter 1 (LAT1)
expression in canine mammary gland tumors. J Vet Med Sci.
75:431–437. 2013. View Article : Google Scholar : PubMed/NCBI
|
28
|
Kaira K, Oriuchi N, Takahashi T, et al:
L-type amino acid transporter 1 (LAT1) expression in malignant
pleural mesothelioma. Anticancer Res. 31:4075–4082. 2011.PubMed/NCBI
|
29
|
Kaira K, Oriuchi N, Imai H, et al: L-type
amino acid transporter 1 (LAT1) is frequently expressed in thymic
carcinomas but is absent in thymomas. J Surg Oncol. 99:433–438.
2009. View Article : Google Scholar : PubMed/NCBI
|
30
|
Ohkawa M, Ohno Y, Masuko K, et al:
Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by
targeted gene disruption in chicken DT40 cells: LAT1 is a promising
molecular target for human cancer therapy. Biochem Biophys Res
Commun. 406:649–655. 2011. View Article : Google Scholar : PubMed/NCBI
|
31
|
del Amo EM, Urtti A and Yliperttula M:
Pharmacokinetic role of L-type amino acid transporters LAT1 and
LAT2. Eur J Pharm Sci. 35:161–174. 2008.PubMed/NCBI
|
32
|
Dickens D, Webb SD, Antonyuk S, et al:
Transport of gabapentin by LAT1 (SLC7A5). Biochem Pharmacol.
85:1672–1683. 2013. View Article : Google Scholar : PubMed/NCBI
|
33
|
Parr RL, Mills J, Harbottle A, et al:
Mitochondria, prostate cancer, and biopsy sampling error. Discov
Med. 15:213–220. 2013.PubMed/NCBI
|
34
|
Bratic A and Larsson NG: The role of
mitochondria in aging. J Clin Invest. 123:951–957. 2013. View Article : Google Scholar
|
35
|
Purdue MP, Hofmann JN, Colt JS, et al: A
case-control study of peripheral blood mitochondrial DNA copy
number and risk of renal cell carcinoma. PLoS One. 7:e431492012.
View Article : Google Scholar : PubMed/NCBI
|
36
|
Qian W and Van Houten B: Alterations in
bioenergetics due to changes in mitochondrial DNA copy number.
Methods. 51:452–457. 2010. View Article : Google Scholar : PubMed/NCBI
|
37
|
Liang BC and Hays L: Mitochondrial DNA
copy number changes in human gliomas. Cancer Lett. 105:167–173.
1996. View Article : Google Scholar : PubMed/NCBI
|
38
|
Kitadai Y: Angiogenesis and
lymphangiogenesis of gastric cancer. J Oncol. 4687252010.PubMed/NCBI
|
39
|
Maehara Y, Hasuda S, Abe T, et al: Tumor
angiogenesis and micrometastasis in bone marrow of patients with
early gastric cancer. Clin Cancer Res. 4:2129–2134. 1998.PubMed/NCBI
|
40
|
Lunt SY and Vander Heiden MG: Aerobic
glycolysis: meeting the metabolic requirements of cell
proliferation. Annu Rev Cell Dev Biol. 27:441–464. 2011. View Article : Google Scholar : PubMed/NCBI
|
41
|
Ferguson EC and Rathmell JC: New roles for
pyruvate kinase M2: working out the Warburg effect. Trends Biochem
Sci. 33:359–362. 2008. View Article : Google Scholar : PubMed/NCBI
|
42
|
Vander Heiden MG, Cantley LC and Thompson
CB: Understanding the Warburg effect: the metabolic requirements of
cell proliferation. Science. 324:1029–1033. 2009.PubMed/NCBI
|
43
|
Mendivil-Perez M, Jimenez-Del-Rio M and
Velez-Pardo C: Glucose starvation induces apoptosis in a model of
acute T leukemia dependent on caspase-3 and apoptosis-inducing
factor: a therapeutic strategy. Nutr Cancer. 65:99–109. 2013.
View Article : Google Scholar
|
44
|
Liu K, Tang Q, Fu C, et al: Influence of
glucose starvation on the pathway of death in insect cell line Sl:
apoptosis follows autophagy. Cytotechnology. 54:97–105. 2007.
View Article : Google Scholar : PubMed/NCBI
|
45
|
Moruno-Manchón JF1, Pérez-Jiménez E and
Knecht E: Glucose induces autophagy under starvation conditions by
a p38 MAPK-dependent pathway. Biochem J. 449:497–506.
2013.PubMed/NCBI
|
46
|
Hayashi K, Jutabha P, Endou H and Anzai N:
c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human
pancreatic cancer cells. Oncol Rep. 28:862–866. 2012.PubMed/NCBI
|
47
|
Haining Z, Kawai N, Miyake K, et al:
Relation of LAT1/4F2hc expression with pathological grade,
proliferation and angiogenesis in human gliomas. BMC Clin Pathol.
12:42012. View Article : Google Scholar : PubMed/NCBI
|
48
|
Ichinoe M, Mikami T, Yoshida T, et al:
High expression of L-type amino-acid transporter 1 (LAT1) in
gastric carcinomas: comparison with non-cancerous lesions. Pathol
Int. 61:281–289. 2011. View Article : Google Scholar : PubMed/NCBI
|
49
|
Khunweeraphong N, Nagamori S,
Wiriyasermkul P, et al: Establishment of stable cell lines with
high expression of heterodimers of human 4F2hc and human amino acid
transporter LAT1 or LAT2 and delineation of their differential
interaction with α-alkyl moieties. J Pharmacol Sci. 119:368–380.
2012.PubMed/NCBI
|
50
|
Jain M, Nilsson R, Sharma S, et al:
Metabolite profiling identifies a key role for glycine in rapid
cancer cell proliferation. Science. 336:1040–1044. 2012. View Article : Google Scholar : PubMed/NCBI
|
51
|
Maddocks OD, Berkers CR, Mason SM, et al:
Serine starvation induces stress and p53-dependent metabolic
remodelling in cancer cells. Nature. 493:542–546. 2013. View Article : Google Scholar : PubMed/NCBI
|
52
|
Filipp FV, Ratnikov B, De Ingeniis J,
Smith JW, Osterman AL and Scott DA: Glutamine-fueled mitochondrial
metabolism is decoupled from glycolysis in melanoma. Pigment Cell
Melanoma Res. 25:732–739. 2012. View Article : Google Scholar : PubMed/NCBI
|
53
|
Shyh-Chang N, Locasale JW, Lyssiotis CA,
et al: Influence of threonine metabolism on
S-adenosylmethionine and histone methylation. Science.
339:222–226. 2013. View Article : Google Scholar : PubMed/NCBI
|
54
|
Zhang WC, Shyh-Chang N, Yang H, et al:
Glycine decarboxylase activity drives non-small cell lung cancer
tumor-initiating cells and tumorigenesis. Cell. 148:259–272. 2012.
View Article : Google Scholar : PubMed/NCBI
|
55
|
Dietrich K, Weltmeier F, Ehlert A, et al:
Heterodimers of the Arabidopsis transcription factors bZIP1
and bZIP53 reprogram amino acid metabolism during low energy
stress. Plant Cell. 23:381–395. 2011.
|
56
|
Kim J and Guan KL: Amino acid signaling in
TOR activation. Annu Rev Biochem. 80:1001–1032. 2011. View Article : Google Scholar : PubMed/NCBI
|
57
|
Lamb RF: Amino acid sensing mechanisms: an
Achilles heel in cancer? FEBS J. 279:2624–2631. 2012. View Article : Google Scholar : PubMed/NCBI
|
58
|
Crimi M and Rigolio R: The mitochondrial
genome, a growing interest inside an organelle. Int J Nanomed.
3:51–57. 2008.PubMed/NCBI
|
59
|
Thyagarajan B, Wang R, Nelson H, Barcelo
H, Koh WP and Yuan JM: Mitochondrial DNA copy number is associated
with breast cancer risk. PLoS One. 8:e659682013. View Article : Google Scholar : PubMed/NCBI
|
60
|
Mondal R, Ghosh SK, Choudhury JH, et al:
Mitochondrial DNA copy number and risk of oral cancer: a report
from Northeast India. PLoS One. 8:e577712013. View Article : Google Scholar : PubMed/NCBI
|
61
|
Monnot S, Samuels DC, Hesters L, et al:
Mutation dependance of the mitochondrial DNA copy number in the
first stages of human embryogenesis. Hum Mol Genet. 22:1867–1872.
2013. View Article : Google Scholar : PubMed/NCBI
|
62
|
Yu M, Wan Y and Zou Q: Reduced
mitochondrial DNA copy number in Chinese patients with
osteosarcoma. Transl Res. 161:165–171. 2013. View Article : Google Scholar : PubMed/NCBI
|
63
|
Gomes LC, Di Benedetto G and Scorrano L:
During autophagy mitochondria elongate, are spared from degradation
and sustain cell viability. Nat Cell Biol. 13:589–598. 2011.
View Article : Google Scholar : PubMed/NCBI
|