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Article

Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling

  • Authors:
    • Chi-Cheng Lu
    • Hao-Ping Chen
    • Jo-Hua Chiang
    • Yi-An Jin
    • Sheng-Chu Kuo
    • Tian-Shung Wu
    • Mann-Jen Hour
    • Jai-Sing Yang
    • Yu-Jen Chiu
  • View Affiliations / Copyright

    Affiliations: Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 402, Taiwan, R.O.C., Department of Biochemistry, Tzu Chi University, Hualien 970, Taiwan, R.O.C., Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, R.O.C., Department of Dermatology, Taipei Medical University Hospital, Taipei 110, Taiwan, R.O.C., Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan, R.O.C., School of Pharmacy, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Pharmacology, School of Medicine, China Medical University, Taichung 404, Taiwan, R.O.C., Division of Reconstructive and Plastic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan, R.O.C.
  • Pages: 597-606
    |
    Published online on: June 12, 2014
       https://doi.org/10.3892/or.2014.3250
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Abstract

The aim of the present study was to explore the effect of 6-fluoro-2-(3-fluorophenyl)-4-(cyanoanilino) quinazoline (HMJ-30) on the anti-angiogenic properties and apoptosis-related mechanism of human umbilical vein endothelial cells (HUVECs). In this study, HMJ-30 dose- and time-dependently inhibited the viability of HUVECs. We also found that HMJ-30 enhanced disruption of tube-like structures and suppressed cell migration in HUVECs after vascular endothelial growth factor (VEGF) induction. HMJ-30 was also observed to inhibit vessel branching and sprouting in chicken chorioallantoic membrane (CAM). Microsprouting induced by VEGF in the rat aortic ring and blood vessel formation in a mouse Matrigel plug were individually suppressed by HMJ-30. In an in vitro study, HMJ-30 induced the apoptotic death of HUVECs as indicated by DNA fragmentation and promoted reactive oxygen species (ROS) production as determined by flow cytometric assay. In addition, extrinsic caspase signaling (caspase-8 and -3) was activated in the HMJ-30-treated HUVECs and their inhibitors were applied to assess the signal transduction. We investigated the upstream of the death receptor pathway and further observed that the levels of death receptor 5 (DR5) and phosphorylated c-Jun N-terminal kinase (JNK) signals were upregulated in HUVECs following HMJ-30 challenge, which was confirmed by a JNK-specific inhibitor (SP600125). Hence, HMJ-30-induced endothelial cell apoptosis involved the ROS/JNK-regulated DR5 pathway. In summary, HMJ-30 may provide a potential therapeutic effect for the anti-vascular targeting of angiogenesis during cancer treatment.
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1 

Kerbel R and Folkman J: Clinical translation of angiogenesis inhibitors. Nat Rev Cancer. 2:727–739. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Tian T, Nan KJ, Wang SH, et al: PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells. Carcinogenesis. 31:1211–1219. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Hasan J, Shnyder SD, Bibby M, Double JA, Bicknel R and Jayson GC: Quantitative angiogenesis assays in vivo - a review. Angiogenesis. 7:1–16. 2004. View Article : Google Scholar

4 

Stoletov K, Kato H, Zardouzian E, et al: Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci. 123:2332–2341. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Ferrara N: VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer. 2:795–803. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Xuan H, Zhao J, Miao J, Li Y, Chu Y and Hu F: Effect of Brazilian propolis on human umbilical vein endothelial cell apoptosis. Food Chem Toxicol. 49:78–85. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Folkman J: Angiogenesis and apoptosis. Semin Cancer Biol. 13:159–167. 2003. View Article : Google Scholar

8 

Plate KH, Breier G, Weich HA, Mennel HD and Risau W: Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer. 59:520–529. 1994. View Article : Google Scholar

9 

Strickler JH and Hurwitz HI: Bevacizumab-based therapies in the first-line treatment of metastatic colorectal cancer. Oncologist. 17:513–524. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Sandler AB, Johnson DH and Herbst RS: Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer. Clin Cancer Res. 10:4258s–4262s. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Yang JC, Haworth L, Sherry RM, et al: A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med. 349:427–434. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Ferrara N, Hillan KJ, Gerber HP and Novotny W: Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov. 3:391–400. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Scott BJ, Quant EC, McNamara MB, Ryg PA, Batchelor TT and Wen PY: Bevacizumab salvage therapy following progression in high-grade glioma patients treated with VEGF receptor tyrosine kinase inhibitors. Neuro Oncol. 12:603–607. 2010. View Article : Google Scholar

14 

Gild ML, Bullock M, Robinson BG and Clifton-Bligh R: Multikinase inhibitors: a new option for the treatment of thyroid cancer. Nat Rev Endocrinol. 7:617–624. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Bottsford-Miller JN, Coleman RL and Sood AK: Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies. J Clin Oncol. 30:4026–4034. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Trowe T, Boukouvala S, Calkins K, et al: EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation. Clin Cancer Res. 14:2465–2475. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Raghav N and Singh M: Design, synthesis and docking studies of bischalcones based quinazoline-2(1H)-ones and quinazoline-2(1H)-thiones derivatives as novel inhibitors of cathepsin B and cathepsin H. Eur J Pharm Sci. 54:28–39. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Bilbro J, Mart M and Kyprianou N: Therapeutic value of quinazoline-based compounds in prostate cancer. Anticancer Res. 33:4695–4700. 2013.PubMed/NCBI

19 

Xu L and Russu WA: Molecular docking and synthesis of novel quinazoline analogues as inhibitors of transcription factors NF-κB activation and their anti-cancer activities. Bioorg Med Chem. 21:540–546. 2013.PubMed/NCBI

20 

Chatterjee N, Das S, Bose D, et al: Exploring the anti-inflammatory activity of a novel 2-phenylquinazoline analog with protection against inflammatory injury. Toxicol Appl Pharmacol. 264:182–191. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Hour MJ, Huang LJ, Kuo SC, et al: 6-Alkylamino- and 2,3-dihydro-3′-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem. 43:4479–4487. 2000.

22 

Chiu YJ, Hour MJ, Lu CC, et al: Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway. J Orthop Res. 29:1448–1456. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Ren T, Qing Y, Dai N, et al: Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells. Cancer Sci. 105:186–194. 2014. View Article : Google Scholar

24 

Wu PP, Liu KC, Huang WW, et al: Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway. Oncol Rep. 25:551–557. 2011.PubMed/NCBI

25 

Yang JS, Hour MJ, Huang WW, Lin KL, Kuo SC and Chung JG: MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells. J Pharmacol Exp Ther. 334:477–488. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Pan SL, Guh JH, Peng CY, et al: YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models. J Pharmacol Exp Ther. 314:35–42. 2005.

27 

Chiang JH, Yang JS, Lu CC, et al: Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling. Toxicol Appl Pharmacol. 269:150–162. 2013. View Article : Google Scholar

28 

Kiriakidis S, Hogemeier O, Starcke S, et al: Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assay. Br J Nutr. 93:317–323. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Pyun BJ, Choi S, Lee Y, et al: Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Cancer Res. 68:227–235. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Pang X, Yi Z, Zhang X, et al: Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Cancer Res. 69:5893–5900. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Pang X, Yi Z, Zhang J, et al: Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. Cancer Res. 70:1951–1959. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Chung JG, Yang JS, Huang LJ, et al: Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice. Proteomics. 7:3305–3317. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Huang WW, Chiu YJ, Fan MJ, et al: Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells. Mol Nutr Food Res. 54:1585–1595. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Lu CC, Yang JS, Chiang JH, et al: Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice. PLoS One. 7:e368312012. View Article : Google Scholar : PubMed/NCBI

35 

Yodkeeree S, Sung B, Limtrakul P and Aggarwal BB: Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. Cancer Res. 69:6581–6589. 2009. View Article : Google Scholar

36 

Prasad S, Yadav VR, Ravindran J and Aggarwal BB: ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins. Cancer Res. 71:538–549. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Aggarwal BB, Bhardwaj U and Takada Y: Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors. Vitam Horm. 67:453–483. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Iwai A, Shiozaki T and Miyazaki T: Relevance of signaling molecules for apoptosis induction on influenza A virus replication. Biochem Biophys Res Commun. 441:531–537. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Kannaiyan R, Shanmugam MK and Sethi G: Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. Cancer Lett. 303:9–20. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Chiang JH, Yang JS, Lu CC, et al: Effect of DNA damage response by quinazolinone analogue HMJ-38 on human umbilical vein endothelial cells: Evidence for γH2A.X and DNA-PK-dependent pathway. Hum Exp Toxicol. 33:590–601. 2014.PubMed/NCBI

41 

Yang JS, Hour MJ, Kuo SC, Huang LJ and Lee MR: Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38. Anticancer Res. 24:1769–1778. 2004.PubMed/NCBI

42 

Lu CC, Yang JS, Chiang JH, et al: Inhibition of invasion and migration by newly synthesized quinazolinone MJ-29 in human oral cancer CAL 27 cells through suppression of MMP-2/9 expression and combined down-regulation of MAPK and AKT signaling. Anticancer Res. 32:2895–2903. 2012.PubMed/NCBI

43 

Tozer GM, Kanthou C and Baguley BC: Disrupting tumour blood vessels. Nat Rev Cancer. 5:423–435. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Portt L, Norman G, Clapp C, Greenwood M and Greenwood MT: Anti-apoptosis and cell survival: a review. Biochim Biophys Acta. 1813:238–259. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Li JH, Kirkiles-Smith NC, McNiff JM and Pober JS: TRAIL induces apoptosis and inflammatory gene expression in human endothelial cells. J Immunol. 171:1526–1533. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Herr I and Debatin KM: Cellular stress response and apoptosis in cancer therapy. Blood. 98:2603–2614. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Zou W, Liu X, Yue P, et al: c-Jun NH2-terminal kinase- mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Res. 64:7570–7578. 2004. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lu C, Chen H, Chiang J, Jin Y, Kuo S, Wu T, Hour M, Yang J and Chiu Y: Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling. Oncol Rep 32: 597-606, 2014.
APA
Lu, C., Chen, H., Chiang, J., Jin, Y., Kuo, S., Wu, T. ... Chiu, Y. (2014). Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling. Oncology Reports, 32, 597-606. https://doi.org/10.3892/or.2014.3250
MLA
Lu, C., Chen, H., Chiang, J., Jin, Y., Kuo, S., Wu, T., Hour, M., Yang, J., Chiu, Y."Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling". Oncology Reports 32.2 (2014): 597-606.
Chicago
Lu, C., Chen, H., Chiang, J., Jin, Y., Kuo, S., Wu, T., Hour, M., Yang, J., Chiu, Y."Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling". Oncology Reports 32, no. 2 (2014): 597-606. https://doi.org/10.3892/or.2014.3250
Copy and paste a formatted citation
x
Spandidos Publications style
Lu C, Chen H, Chiang J, Jin Y, Kuo S, Wu T, Hour M, Yang J and Chiu Y: Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling. Oncol Rep 32: 597-606, 2014.
APA
Lu, C., Chen, H., Chiang, J., Jin, Y., Kuo, S., Wu, T. ... Chiu, Y. (2014). Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling. Oncology Reports, 32, 597-606. https://doi.org/10.3892/or.2014.3250
MLA
Lu, C., Chen, H., Chiang, J., Jin, Y., Kuo, S., Wu, T., Hour, M., Yang, J., Chiu, Y."Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling". Oncology Reports 32.2 (2014): 597-606.
Chicago
Lu, C., Chen, H., Chiang, J., Jin, Y., Kuo, S., Wu, T., Hour, M., Yang, J., Chiu, Y."Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling". Oncology Reports 32, no. 2 (2014): 597-606. https://doi.org/10.3892/or.2014.3250
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