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Article

Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway

  • Authors:
    • Huiyan Niu
    • Yifei Zhang
    • Baogang Wu
    • Yi Zhang
    • Hongfang Jiang
    • Ping He
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China
  • Pages: 1087-1093
    |
    Published online on: June 20, 2014
       https://doi.org/10.3892/or.2014.3273
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Abstract

Lung cancer is the leading cause of cancer‑related mortality in humans. The prognosis for advanced lung cancer patients is extremely poor. Current standard care is rather ineffective for prolonging patient life while preserving satisfactory quality of life due to adverse side-effects. Matrine extracted from the traditional Chinese herbal plant Sophora flavescens was shown to induce cancer cell death in vitro. The aim of this study was to investigate the effect of matrine on the proliferation and apoptosis of lung cancer cells and the molecular basis of matrine-induced apoptosis. The results showed that matrine inhibited cell proliferation and induced apoptosis in lung cancer A549 and 95D cells in a dose- and time-dependent manner. The apoptotic effects of matrine on lung cancer cells appeared to act via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway and downregulation of the expression of the inhibitor of apoptosis protein (IAP) family proteins. Matrine exerts its cancer-killing effect via promoting apoptosis in lung cancer cells and may be a useful adjuvant therapeutic scheme for treating advanced lung cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Niu H, Zhang Y, Wu B, Zhang Y, Jiang H and He P: Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway. Oncol Rep 32: 1087-1093, 2014.
APA
Niu, H., Zhang, Y., Wu, B., Zhang, Y., Jiang, H., & He, P. (2014). Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway. Oncology Reports, 32, 1087-1093. https://doi.org/10.3892/or.2014.3273
MLA
Niu, H., Zhang, Y., Wu, B., Zhang, Y., Jiang, H., He, P."Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway". Oncology Reports 32.3 (2014): 1087-1093.
Chicago
Niu, H., Zhang, Y., Wu, B., Zhang, Y., Jiang, H., He, P."Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway". Oncology Reports 32, no. 3 (2014): 1087-1093. https://doi.org/10.3892/or.2014.3273
Copy and paste a formatted citation
x
Spandidos Publications style
Niu H, Zhang Y, Wu B, Zhang Y, Jiang H and He P: Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway. Oncol Rep 32: 1087-1093, 2014.
APA
Niu, H., Zhang, Y., Wu, B., Zhang, Y., Jiang, H., & He, P. (2014). Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway. Oncology Reports, 32, 1087-1093. https://doi.org/10.3892/or.2014.3273
MLA
Niu, H., Zhang, Y., Wu, B., Zhang, Y., Jiang, H., He, P."Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway". Oncology Reports 32.3 (2014): 1087-1093.
Chicago
Niu, H., Zhang, Y., Wu, B., Zhang, Y., Jiang, H., He, P."Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway". Oncology Reports 32, no. 3 (2014): 1087-1093. https://doi.org/10.3892/or.2014.3273
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