Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma

  • Authors:
    • Shunqin Zhu
    • Wanhong Liu
    • Xiaoxue Ke
    • Jifu Li
    • Renjian Hu
    • Hongjuan Cui
    • Guanbin Song
  • View Affiliations

  • Published online on: July 11, 2014     https://doi.org/10.3892/or.2014.3323
  • Pages: 1094-1100
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Abstract

Artemisinin, a natural product from the Chinese medicinal plant, Artemisia annua L., is commonly used in the treatment of malaria, and has recently been reported to have potent anticancer activity in various types of human tumors. Yet, the effect of artemisinin on neuroblastoma is still unclear. In the present study, we aimed to investigate the effects of artemisinin on neuroblastoma cells. We observed that artemisinin significantly inhibited cell growth and proliferation, and caused cell cycle arrest in the G1 phase in neuroblastoma cell lines. Annexin V-FITC/PI staining assay revealed that artemisinin markedly induced apoptosis. Soft agar assays revealed that artemisinin suppressed the ability of clonogenic formation of neuroblastoma cells and a xenograft study in NOD/SCID mice showed that artemisinin inhibited tumor growth and development in vivo. Therefore, our results suggest that the Chinese medicine artemisinin could serve as a novel potential therapeutic agent in the treatment of neuroblastoma.
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September-2014
Volume 32 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhu S, Liu W, Ke X, Li J, Hu R, Cui H and Song G: Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma. Oncol Rep 32: 1094-1100, 2014
APA
Zhu, S., Liu, W., Ke, X., Li, J., Hu, R., Cui, H., & Song, G. (2014). Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma. Oncology Reports, 32, 1094-1100. https://doi.org/10.3892/or.2014.3323
MLA
Zhu, S., Liu, W., Ke, X., Li, J., Hu, R., Cui, H., Song, G."Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma". Oncology Reports 32.3 (2014): 1094-1100.
Chicago
Zhu, S., Liu, W., Ke, X., Li, J., Hu, R., Cui, H., Song, G."Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma". Oncology Reports 32, no. 3 (2014): 1094-1100. https://doi.org/10.3892/or.2014.3323