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Article Open Access

Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms

  • Authors:
    • Sven-Petter Haugvik
    • Ludmila Gorunova
    • Lisbeth Haugom
    • Anne  Mette Eibak
    • Ivar Prydz Gladhaug
    • Sverre Heim
    • Francesca Micci
  • View Affiliations / Copyright

    Affiliations: Department of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, 0372 Oslo, Norway, Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, 0372 Oslo, Norway, Institute of Clinical Medicine, University of Oslo, 0372 Oslo, Norway
    Copyright: © Haugvik et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 906-912
    |
    Published online on: July 11, 2014
       https://doi.org/10.3892/or.2014.3328
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Abstract

The pathogenesis of sporadic pancreatic neuroendocrine neoplasms (PNENs) is poorly understood. To gain insight into the genetic mechanisms underlying this tumor entity, we performed genome-wide screening of 16 surgical specimens from 15 patients with sporadic PNEN, combining G-band karyotyping and high resolution comparative genomic hybridization (HR-CGH). G-banding revealed abnormal karyotypes in 2 of 10 tumor samples analyzed. DNA copy number changes were detected in 13 samples, whereas three tumors showed a balanced genome. Gains were more frequent than losses in the nonfunctioning tumors (n=13). Common gains were scored at 5p12-13, 4q13-24, 5p15, 5q11-31, and 9q21-22. Common losses were scored at 11p11, 11p14-15, 11q23, 11p12-13, and 11q22. The average number of copy aberrations (ANCA index) was 12 for 13 nonfunctioning primary tumors, 4.8 for the nonfunctioning tumors with low Ki-67 (≥5%), 21.2 for the tumors with high Ki-67 (<5%), 2.5 for small tumors (<3.5 cm), and 17.8 for large tumors (≥3.5 cm). There was a statistically significant difference in the ANCA index between the groups defined by Ki-67 and tumor size. Nonfunctioning tumors with low Ki-67, no distant metastasis and small size had few aberrations detected by HR-CGH, but frequent loss of material from chromosomal band 11p11. The present study indicates the existence of distinct cytogenetic patterns in sporadic nonfunctioning PNEN. Loss of chromosomal band 11p11 might indicate a primary pathogenetic event in these tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Haugvik S, Gorunova L, Haugom L, Eibak AM, Gladhaug IP, Heim S and Micci F: Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms. Oncol Rep 32: 906-912, 2014.
APA
Haugvik, S., Gorunova, L., Haugom, L., Eibak, A.M., Gladhaug, I.P., Heim, S., & Micci, F. (2014). Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms. Oncology Reports, 32, 906-912. https://doi.org/10.3892/or.2014.3328
MLA
Haugvik, S., Gorunova, L., Haugom, L., Eibak, A. M., Gladhaug, I. P., Heim, S., Micci, F."Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms". Oncology Reports 32.3 (2014): 906-912.
Chicago
Haugvik, S., Gorunova, L., Haugom, L., Eibak, A. M., Gladhaug, I. P., Heim, S., Micci, F."Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms". Oncology Reports 32, no. 3 (2014): 906-912. https://doi.org/10.3892/or.2014.3328
Copy and paste a formatted citation
x
Spandidos Publications style
Haugvik S, Gorunova L, Haugom L, Eibak AM, Gladhaug IP, Heim S and Micci F: Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms. Oncol Rep 32: 906-912, 2014.
APA
Haugvik, S., Gorunova, L., Haugom, L., Eibak, A.M., Gladhaug, I.P., Heim, S., & Micci, F. (2014). Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms. Oncology Reports, 32, 906-912. https://doi.org/10.3892/or.2014.3328
MLA
Haugvik, S., Gorunova, L., Haugom, L., Eibak, A. M., Gladhaug, I. P., Heim, S., Micci, F."Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms". Oncology Reports 32.3 (2014): 906-912.
Chicago
Haugvik, S., Gorunova, L., Haugom, L., Eibak, A. M., Gladhaug, I. P., Heim, S., Micci, F."Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms". Oncology Reports 32, no. 3 (2014): 906-912. https://doi.org/10.3892/or.2014.3328
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