Open Access

Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms

  • Authors:
    • Sven-Petter Haugvik
    • Ludmila Gorunova
    • Lisbeth Haugom
    • Anne  Mette Eibak
    • Ivar Prydz Gladhaug
    • Sverre Heim
    • Francesca Micci
  • View Affiliations

  • Published online on: July 11, 2014     https://doi.org/10.3892/or.2014.3328
  • Pages: 906-912
  • Copyright: © Haugvik et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

The pathogenesis of sporadic pancreatic neuroendocrine neoplasms (PNENs) is poorly understood. To gain insight into the genetic mechanisms underlying this tumor entity, we performed genome-wide screening of 16 surgical specimens from 15 patients with sporadic PNEN, combining G-band karyotyping and high resolution comparative genomic hybridization (HR-CGH). G-banding revealed abnormal karyotypes in 2 of 10 tumor samples analyzed. DNA copy number changes were detected in 13 samples, whereas three tumors showed a balanced genome. Gains were more frequent than losses in the nonfunctioning tumors (n=13). Common gains were scored at 5p12-13, 4q13-24, 5p15, 5q11-31, and 9q21-22. Common losses were scored at 11p11, 11p14-15, 11q23, 11p12-13, and 11q22. The average number of copy aberrations (ANCA index) was 12 for 13 nonfunctioning primary tumors, 4.8 for the nonfunctioning tumors with low Ki-67 (≥5%), 21.2 for the tumors with high Ki-67 (<5%), 2.5 for small tumors (<3.5 cm), and 17.8 for large tumors (≥3.5 cm). There was a statistically significant difference in the ANCA index between the groups defined by Ki-67 and tumor size. Nonfunctioning tumors with low Ki-67, no distant metastasis and small size had few aberrations detected by HR-CGH, but frequent loss of material from chromosomal band 11p11. The present study indicates the existence of distinct cytogenetic patterns in sporadic nonfunctioning PNEN. Loss of chromosomal band 11p11 might indicate a primary pathogenetic event in these tumors.
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September-2014
Volume 32 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Haugvik S, Gorunova L, Haugom L, Eibak AM, Gladhaug IP, Heim S and Micci F: Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms. Oncol Rep 32: 906-912, 2014.
APA
Haugvik, S., Gorunova, L., Haugom, L., Eibak, A.M., Gladhaug, I.P., Heim, S., & Micci, F. (2014). Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms. Oncology Reports, 32, 906-912. https://doi.org/10.3892/or.2014.3328
MLA
Haugvik, S., Gorunova, L., Haugom, L., Eibak, A. M., Gladhaug, I. P., Heim, S., Micci, F."Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms". Oncology Reports 32.3 (2014): 906-912.
Chicago
Haugvik, S., Gorunova, L., Haugom, L., Eibak, A. M., Gladhaug, I. P., Heim, S., Micci, F."Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms". Oncology Reports 32, no. 3 (2014): 906-912. https://doi.org/10.3892/or.2014.3328