Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
October 2014 Volume 32 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October 2014 Volume 32 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer

  • Authors:
    • Yutaka Naito
    • Kyohei Yasuno
    • Hiroko Tagawa
    • Naoya  Sakamoto
    • Naohide  Oue
    • Masakazu  Yashiro
    • Kazuhiro  Sentani
    • Keisuke  Goto
    • Shunsuke  Shinmei
    • Htoo  Zarni Oo
    • Kazuyoshi Yanagihara
    • Kosei Hirakawa
    • Wataru Yasui
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Minami‑ku, Hiroshima 734-8551, Japan, Faculty of Medicine, Hiroshima University, Minami‑ku, Hiroshima 734-8551, Japan, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan, Division of Translational Research, Exploratory Oncology and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan
  • Pages: 1720-1726
    |
    Published online on: July 16, 2014
       https://doi.org/10.3892/or.2014.3333
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastric cancer (GC) is one of the most common malignancies worldwide. In particular, scirrhous type GC is highly metastatic and is characterized clinically by rapid disease progression and poor prognosis. MicroRNAs (miRNAs) play crucial roles in cancer development and progression. We previously demonstrated by microarray analysis that microRNA-145 (miR-145) is one of the more highly expressed miRNAs in scirrhous type GC vs. non-scirrhous types of GC. In the present study, we investigated the role of miR-145 in scirrhous type GC. The expression levels of miR-145 assessed by quantitative RT-PCR were higher in scirrhous type GC tissue samples than in non-scirrhous type GC and corresponding normal tissues. GC patients with high miR-145 expression were at a more advanced tumor stage (P=0.0156) and had more scirrhous type histology (P=0.0054) than those with low miR-145 expression. Furthermore, miR-145 expression was significantly associated with poor prognosis in GC patients (P=0.0438). miR-145 expression was localized in stromal fibroblasts of scirrhous type GC but not in cancer cells. miR-145 was induced by treatment by transforming growth factor-β, and it enhanced the expression of α-smooth muscle actin, a marker of myofibroblasts, in both normal gastric fibroblasts and cancer-associated fibroblasts. These data suggest that miR-145 may contribute to the progression of scirrhous type GC by regulating activation of peri-tumoral fibroblasts.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Otsuji E, Kuriu Y, Okamoto K, et al: Outcome of surgical treatment for patients with scirrhous carcinoma of the stomach. Am J Surg. 188:327–332. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Ikeguchi M, Miyake T, Matsunaga T, et al: Recent results of therapy for scirrhous gastric cancer. Surg Today. 39:290–294. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Yashiro M and Hirakawa K: Cancer-stromal interactions in scirrhous gastric carcinoma. Cancer Microenviron. 3:127–135. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Yamamoto M, Sumiyoshi H, Nakagami K, Taniyama K and Tahara E: Distribution of collagen types I and III and basal lamina in human gastric carcinoma: an immunohistochemical and electron microscopic study. Virchows Arch A Pathol Anat Histopathol. 403:313–322. 1984. View Article : Google Scholar : PubMed/NCBI

5 

Yoshida K, Yokozaki H, Niimoto M, Ito H, Ito M and Tahara E: Expression of TGF-β and procollagen type I and type III in human gastric carcinomas. Int J Cancer. 44:394–398. 1989.

6 

Jain RK: Barriers to drug delivery in solid tumors. Sci Am. 271:58–65. 1994. View Article : Google Scholar : PubMed/NCBI

7 

Heldin CH, Rubin K, Pietras K and Ostman A: High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer. 4:806–813. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Nakajima TE, Yanagihara K, Takigahira M, et al: Antitumor effect of SN-38-releasing polymeric micelles, NK012, on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan. Cancer Res. 68:9318–9322. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Worthley DL, Giraud AS and Wang TC: The extracellular matrix in digestive cancer. Cancer Microenviron. 3:177–185. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Naito Y, Sakamoto N, Oue N, et al: MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer. Cancer Sci. 105:228–235. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Cordes KR, Sheehy NT, White MP, et al: miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 460:705–710. 2009.PubMed/NCBI

15 

Iio A, Nakagawa Y, Hirata I, Naoe T and Akao Y: Identification of non-coding RNAs embracing microRNA-143/145 cluster. Mol Cancer. 9:1362010. View Article : Google Scholar : PubMed/NCBI

16 

Long X and Miano JM: Transforming growth factor-β1 (TGF-β1) utilized distinct pathways for the transcriptional activation of microRNA 143/145 in human coronary artery smooth muscle cells. J Biol Chem. 286:30119–30129. 2011.

17 

Ochiai A, Yasui W, Kameda T, Takanashi A, Takekura N and Tahara E: The effect of phorbol esters on cell growth and epidermal growth factor receptor modulation in a human gastric carcinoma cell line TMK-1. Hiroshima J Med Sci. 38:191–195. 1989.PubMed/NCBI

18 

Yanagihara K, Seyama T, Tsumuraya M, Kamada N and Yokoro K: Establishment and characterization of human signet ring cell gastric carcinoma cell lines with amplification of the c-myc oncogene. Cancer Res. 51:381–386. 1991.PubMed/NCBI

19 

Yanagihara K, Tanaka H, Takigahira M, et al: Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice. Cancer Sci. 95:575–582. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Fuyuhiro Y, Yashiro M, Noda S, et al: Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells. Cancer Sci. 103:797–805. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Naito Y, Oue N, Hinoi T, et al: Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer. PLoS One. 7:e475452012. View Article : Google Scholar : PubMed/NCBI

22 

Kondo T, Oue N, Yoshida K, et al: Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma. Cancer Res. 64:523–529. 2004.

23 

Shinmei S, Sakamoto N, Goto K, et al: MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma. Int J Urol. 20:468–477. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Yasui W, Ayhan A, Kitadai Y, et al: Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas. Int J Cancer. 53:36–41. 1993. View Article : Google Scholar : PubMed/NCBI

25 

Ueda T, Volinia S, Okumura H, et al: Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol. 11:136–146. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Liu L, Chen Q, Lai R, et al: Elevated expression of mature miR-21 and miR-155 in cancerous gastric tissues from Chinese patients with gastric cancer. J Biomed Res. 24:187–197. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Gao P, Xing AX, Zhou GY, et al: The molecular mechanism of microRNA-145 to suppress invasion-metastasis cascade in gastric cancer. Oncogene. 32:491–501. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Zheng L, Pu J, Qi T, et al: miRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis, and angiogenesis of gastric cancer cells. Mol Cancer Res. 11:182–193. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Ostenfeid MS, Bramsen JB, Lamy P, et al: miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors. Oncogene. 29:1073–1084. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Hamano R, Miyata H, Yamasaki M, et al: Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the akt signaling pathway. Clin Cancer Res. 17:3029–3038. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Villadsen SB, Bramsen JB, Ostenfeld MS, et al: The miR-143/−145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer. Br J Cancer. 106:366–374. 2012.

32 

Kalluri R and Zeisberg M: Fibroblasts in cancer. Nat Rev Cancer. 6:392–401. 2006. View Article : Google Scholar

33 

Yang S, Cui H, Xie N, et al: miR-145 regulates myofibroblast differentiation and lung fibrosis. FASEB J. 27:2382–2391. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Mahara K, Kato J, Terui T, et al: Transforming growth factor beta 1 secreted from scirrhous gastric cancer cells is associated with excess collagen deposition in the tissue. Br J Cancer. 69:777–783. 1994. View Article : Google Scholar : PubMed/NCBI

35 

Kawajiri H, Yashiro M, Shinto O, et al: A novel transforming growth factor β receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma. Clin Cancer Res. 14:2850–2860. 2008.

36 

Shinto O, Yashiro M, Kawajiri H, et al: Inhibitory effect of a TGFβ receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells. Br J Cancer. 102:844–851. 2010.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Naito Y, Yasuno K, Tagawa H, Sakamoto N, Oue N, Yashiro M, Sentani K, Goto K, Shinmei S, Oo HZ, Oo HZ, et al: MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer. Oncol Rep 32: 1720-1726, 2014.
APA
Naito, Y., Yasuno, K., Tagawa, H., Sakamoto, N., Oue, N., Yashiro, M. ... Yasui, W. (2014). MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer. Oncology Reports, 32, 1720-1726. https://doi.org/10.3892/or.2014.3333
MLA
Naito, Y., Yasuno, K., Tagawa, H., Sakamoto, N., Oue, N., Yashiro, M., Sentani, K., Goto, K., Shinmei, S., Oo, H. Z., Yanagihara, K., Hirakawa, K., Yasui, W."MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer". Oncology Reports 32.4 (2014): 1720-1726.
Chicago
Naito, Y., Yasuno, K., Tagawa, H., Sakamoto, N., Oue, N., Yashiro, M., Sentani, K., Goto, K., Shinmei, S., Oo, H. Z., Yanagihara, K., Hirakawa, K., Yasui, W."MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer". Oncology Reports 32, no. 4 (2014): 1720-1726. https://doi.org/10.3892/or.2014.3333
Copy and paste a formatted citation
x
Spandidos Publications style
Naito Y, Yasuno K, Tagawa H, Sakamoto N, Oue N, Yashiro M, Sentani K, Goto K, Shinmei S, Oo HZ, Oo HZ, et al: MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer. Oncol Rep 32: 1720-1726, 2014.
APA
Naito, Y., Yasuno, K., Tagawa, H., Sakamoto, N., Oue, N., Yashiro, M. ... Yasui, W. (2014). MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer. Oncology Reports, 32, 1720-1726. https://doi.org/10.3892/or.2014.3333
MLA
Naito, Y., Yasuno, K., Tagawa, H., Sakamoto, N., Oue, N., Yashiro, M., Sentani, K., Goto, K., Shinmei, S., Oo, H. Z., Yanagihara, K., Hirakawa, K., Yasui, W."MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer". Oncology Reports 32.4 (2014): 1720-1726.
Chicago
Naito, Y., Yasuno, K., Tagawa, H., Sakamoto, N., Oue, N., Yashiro, M., Sentani, K., Goto, K., Shinmei, S., Oo, H. Z., Yanagihara, K., Hirakawa, K., Yasui, W."MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer". Oncology Reports 32, no. 4 (2014): 1720-1726. https://doi.org/10.3892/or.2014.3333
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team