Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

Rasmussen,Jacob  Ø.; von Holstein,Sarah  L.; Prause,Jan  U.; Vainer,Ben; Hansen,Alastair  B.; Fehr,André; Stenman,Göran; Heegaard,Steffen

doi:10.3892/or.2014.3345

Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

Authors:
- Jacob Ø. Rasmussen
- Sarah L. von Holstein
- Jan U. Prause
- Ben Vainer
- Alastair B. Hansen
- André Fehr
- Göran Stenman
- Steffen Heegaard
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Affiliations: Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark, Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark, Sahlgrenska Cancer Center, Department of Pathology, University of Gothenburg, Gothenburg, Sweden
Published online on: July 21, 2014 https://doi.org/10.3892/or.2014.3345
Pages: 1447-1450

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Abstract

A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.

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