Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

Rasmussen,Jacob  Ø.; von Holstein,Sarah  L.; Prause,Jan  U.; Vainer,Ben; Hansen,Alastair  B.; Fehr,André; Stenman,Göran; Heegaard,Steffen

doi:10.3892/or.2014.3345

October 2014 Volume 32 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October 2014 Volume 32 Issue 4

Full Size Image

Article

Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

Authors:
- Jacob Ø. Rasmussen
- Sarah L. von Holstein
- Jan U. Prause
- Ben Vainer
- Alastair B. Hansen
- André Fehr
- Göran Stenman
- Steffen Heegaard
View Affiliations / Copyright

Affiliations: Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark, Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark, Sahlgrenska Cancer Center, Department of Pathology, University of Gothenburg, Gothenburg, Sweden
Pages: 1447-1450
|
Published online on: July 21, 2014

https://doi.org/10.3892/or.2014.3345
Expand metrics +

Abstract

A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.

View Figures

View References

1	Pinchot SN, Holen K, Sippel RS and Chen H: Carcinoid Tumors. Oncologist. 13:1255–1269. 2008. View Article : Google Scholar : PubMed/NCBI
2	Williams ED and Sandler M: The classification of carcinoid tumours. Lancet. 1:238–239. 1963. View Article : Google Scholar : PubMed/NCBI
3	Friedman JR and Kaestner KH: On the origin of the liver. J Clin Invest. 121:4630–4633. 2011. View Article : Google Scholar : PubMed/NCBI
4	Modlin IM, Lye KD and Kidd M: A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 97:934–959. 2003. View Article : Google Scholar : PubMed/NCBI
5	Mehta JS, Abou-Rayyah Y and Rose GE: Orbital carcinoid metastases. Ophthalmology. 113:466–472. 2006. View Article : Google Scholar : PubMed/NCBI
6	Fenoglio LM, Severini S, Ferrigno D and Gollè G: Primary hepatic carcinoid: A case report and literature review. World J Gastroenterol. 15:2418–2422. 2009. View Article : Google Scholar : PubMed/NCBI
7	Turaka K, Mashayekhi A and Shields Cl: A case series of neuroendocrine (carcinoid) tumor metastasis to the orbit. Oman J Ophthalmol. 4:125–128. 2011. View Article : Google Scholar : PubMed/NCBI
8	Gupta A, Chazen JL and Phillips CD: Carcinoid tumor metastases to the extraocular muscles: MR imaging and CT findings and review of the literature. AJNR Am J Neuroradiol. 32:1208–1211. 2011. View Article : Google Scholar : PubMed/NCBI
9	Matsuo T, Ichimura K, Tanaka T and Takenaka T: Neuroendocrine tumor (carcinoid) metastatic to orbital extraocular muscle: case report and literature review. Strabismus. 18:123–128. 2010. View Article : Google Scholar : PubMed/NCBI
10	Barrett MT, Scheffer A, Ben-Dor A, Sampas N, Lipson D, Kincaid R, Tsang P, Curry B, Baird K, Meltzer PS, Yakhini Z, Bruhn L and Laderman S: Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA. Proc Natl Acad Sci USA. 101:17765–17770. 2004. View Article : Google Scholar : PubMed/NCBI
11	Persson F, Winnes M, Andrén Y, et al: High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes. Oncogene. 27:3072–3080. 2008. View Article : Google Scholar : PubMed/NCBI
12	Zikusoka MN, Kidd M, Eick G, Latich I and Modlin IM: The molecular genetics of gastroenteropancreatic neuroendocrine tumors. Cancer. 104:2292–2309. 2005. View Article : Google Scholar : PubMed/NCBI
13	Andersson E, Swärd C, Stenman G, Ahlman H and Nilsson O: High-resolution genomic profiling reveals gain of chromosome 14 as a predictor of poor outcome in ileal carcinoids. Endocr Relat Cancer. 16:953–966. 2009. View Article : Google Scholar : PubMed/NCBI
14	Leotlela PD, Jauch A, Holtgreve-Grez H and Thakker RV: Genetics of neuroendocrine and carcinoid tumours. Endocr Relat Cancer. 10:437–450. 2003. View Article : Google Scholar : PubMed/NCBI
15	Tönnies H, Toliat MR, Ramel C and Pape UF: Analysis of sporadic neuroendocrine tumours of the enteropancreatic system by comparative genomic hybridisation. Gut. 48:536–541. 2001.PubMed/NCBI
16	Guerriero S, Infante G and Giancipoli E: Hepatocellular carcinoma metastasis to the orbit in a coinfected HIV⁺ HBV⁺ patient previously treated with orthotopic liver transplantation: a case report. Case Rep Ophthalmol Med. 2011:5492702011.PubMed/NCBI
17	Hirunwiwatkul P, Tirakunwichcha S, Meesuaypong P and Shuangshoti S: Orbital metastasis of hepatocellular carcinoma. J Neuroophthalmol. 28:47–50. 2008. View Article : Google Scholar
18	van Malenstein H, van Pelt J and Verslype C: Molecular classification of hepatocellular carcinoma anno 2011. Eur J Cancer. 47:1789–1797. 2011.PubMed/NCBI
19	Gao J, Hu Z, Wu J, Bai L and Chai X: Primary hepatic carcinoid tumor. World J Surg Oncol. 9:1512011. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles