Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
October 2014 Volume 32 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October 2014 Volume 32 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

NRP-1 expression is strongly associated with the progression of pituitary adenomas

  • Authors:
    • Sang Won Lee
    • Jung Eun Lee
    • Chang Young Yoo
    • Myoung Seok Ko
    • Chan Soon Park
    • Seung-Ho Yang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, St. Vincent's Hospital, The Catholic University of Korea, Paldal-gu, Suwon 442-723, Republic of Korea, Department of Pathology, St. Vincent's Hospital, The Catholic University of Korea, Paldal-gu, Suwon 442-723, Republic of Korea, Asan Institute for Life Sciences, Asan Medical Center, Seoul 138-736, Republic of Korea, Department of Otolaryngology, St. Vincent's Hospital, The Catholic University of Korea, Paldal-gu, Suwon 442-723, Republic of Korea
  • Pages: 1537-1542
    |
    Published online on: August 7, 2014
       https://doi.org/10.3892/or.2014.3392
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of the present study was to identify a predictive marker associated with tumor progression or recurrence. We investigated the expression of p53, Ki-67, Bax, Bcl-2, vascular endothelial growth factor (VEGF)-A, VEGFR-1, VEGFR-2 and neuropilin-1 (NRP-1) in pituitary adenomas (PAs) with/without tumor progression during follow-up periods. We compared the expression of these molecules in primary and recurrent specimens to identify a predictive marker associated with tumor progression. Nineteen patients had no progression for more than 5-years of follow-up. Nine patients had tumor progression within 5 years of their first transsphenoidal surgery (TSS) surgery and underwent re-TSS for treating progression of adenoma. Tumor size was larger and involvement of the cavernous sinus was more frequent in the progression group than these variables in the no progression group. A strong association was observed between NRP-1 expression and tumor progression. No significant risk for developing tumor progression was associated with Ki-67, p53, Bax, Bcl-2, VEGFR-1, VEGFR-2, or VEGF-A expression. Four of nine patients showed strong NRP-1 immunoreactivity in progression specimens. Negative NRP-1 immunoreactivity in the initial specimens was converted into strong positivity in the progression specimens of five patients. NRP-1 could be a relevant PA marker of progression and could be a potential target for medical therapy.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ezzat S, Asa SL, Couldwell WT, et al: The prevalence of pituitary adenomas: a systematic review. Cancer. 101:613–619. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Hsu DW, Hakim F, Biller BM, et al: Significance of proliferating cell nuclear antigen index in predicting pituitary adenoma recurrence. J Neurosurg. 78:753–761. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Gejman R, Swearingen B and Hedley-Whyte ET: Role of Ki-67 proliferation index and p53 expression in predicting progression of pituitary adenomas. Hum Pathol. 39:758–766. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Lloyd RV: Pituitary tumors. World Health Organization Classification of Tumors, Pathology and Genetics of Tumors of Endocrine Organs. DeLellis A: IARC Press; Lyon: pp. 10–13. 2004

5 

Hentschel SJ, McCutcheon lE, Moore W and Durity FA: P53 and MIB-1 immunohistochemistry as predictors of the clinical behavior of nonfunctioning pituitary adenomas. Can J Neurol Sci. 30:215–219. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Sambaziotis D, Kapranos N and Kontogeorgos G: Correlation of bcl-2 and bax with apoptosis in human pituitary adenomas. Pituitary. 6:127–133. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Iuchi T, Saeki N, Osato K and Yamaura A: Proliferation, vascular endothelial growth factor expression and cavernous sinus invasion in growth hormone secreting pituitary adenomas. Acta Neurochir. 142:1345–1351. 2000. View Article : Google Scholar

8 

Cohen AB and Lessell S: Angiogenesis and pituitary tumors. Semin Ophthalmol. 24:185–189. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Tammela T, Enholm B, Alitalo K and Paavonen K: The biology of vascular endothelial growth factors. Cardiovasc Res. 65:550–563. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Oh H, Takagi H, Otani A, et al: Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis. Proc Natl Acad Sci USA. 99:383–388. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Benveniste RJ, King WA, Walsh J, et al: Repeated transsphenoidal surgery to treat recurrent or residual pituitary adenoma. J Neurosurg. 102:1004–1012. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Lee JS, Yoon A, Kalapurakal SK, et al: Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor. J Clin Oncol. 13:1893–1903. 1995.PubMed/NCBI

13 

Thunnissen FB, Schuurbiers OC and den Bakker MA: A critical appraisal of prognostic and predictive factors for common lung cancers. Histopathology. 48:779–786. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Bielenberg DR, Pettaway CA, Takashima S and Klagsbrun M: Neuropilins in neoplasms: expression, regulation, and function. Exp Cell Res. 312:584–593. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Guttmann-Raviv N, Kessler O, Shraga-Heled N, et al: The neuropilins and their role in tumorigenesis and tumor progression. Cancer Lett. 231:1–11. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Turner HE, Nagy Z, Gatter KC, et al: Angiogenesis in pituitary adenomas and the normal pituitary gland. J Clin Endocrinol Metab. 85:1159–1162. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Di Ieva A, Grizzi F, Ceva-Grimaldi G, et al: Fractal dimension as a quantitator of the microvasculature of normal and adenomatous pituitary tissue. J Anat. 211:673–680. 2007.PubMed/NCBI

18 

Takada K, Yamada S and Teramoto A: Correlation between tumor vascularity and clinical findings in patients with pituitary adenomas. Endocr Pathol. 15:131–139. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Fukui S, Nawashiro H, Otani N, et al: Vascular endothelial growth factor expression in pituitary adenomas. Acta Neurochir Suppl. 86:519–521. 2003.PubMed/NCBI

20 

Fukui S, Otani N, Nawashiro H, et al: The association of the expression of vascular endothelial growth factor with the cystic component and haemorrhage in pituitary adenoma. J Clin Neurosci. 10:320–324. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Sánchez-Ortiga R, Sánchez-Tejada L, Moreno-Perez O, et al: Over-expression of vascular endothelial growth factor in pituitary adenomas is associated with extrasellar growth and recurrence. Pituitary. 16:370–377. 2013.PubMed/NCBI

22 

Onofri C, Theodoropoulou M, Losa M, et al: Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a non-endothelial function of VEGF in pituitary tumours. J Endocrinol. 191:249–261. 2006. View Article : Google Scholar

23 

Cristina C, Perez-Millan MI, Luque G, et al: VEGF and CD31 association in pituitary adenomas. Endocr Pathol. 21:154–160. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Nör JE, Christensen J, Mooney DJ and Polverini PJ: Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol. 154:375–384. 1999.PubMed/NCBI

25 

Turner HE, Nagy Z, Gatter KC, Esiri MM, et al: Proliferation, bcl-2 expression and angiogenesis in pituitary adenomas: relationship to tumour behaviour. Br J Cancer. 82:1441–1445. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Pan Q, Chanthery Y, Liang WC, et al: Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell. 11:53–67. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Banerjee SK, Zoubine MN, Tran TM, et al: Overexpression of vascular endothelial growth factor164 and its co-receptor neuropilin-1 in estrogen-induced rat pituitary tumors and GH3 rat pituitary tumor cells. Int J Oncol. 16:253–260. 2000.PubMed/NCBI

28 

Pan Q, Chathery Y, Wu Y, et al: Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J Biol Chem. 282:24049–24056. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Fu L, Kitamura T, Iwabuchi K, Ichinose S, et al: Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats. World J Gastroenterol. 18:5034–5041. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Matthies AM, Low QE, Lingen MW and DiPietro LA: Neuropilin-1 participates in wound angiogenesis. Am J Pathol. 160:289–296. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Brusselmans K, Bono F, Collen D, et al: A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia. J Biol Chem. 280:3493–3499. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Korsisaari N, Ross J, Wu X, et al: Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1. Clin Cancer Res. 14:249–258. 2008. View Article : Google Scholar

33 

Ortiz LD, Syro LV, Scheithauer BW, et al: Anti-VEGF therapy in pituitary carcinoma. Pituitary. 15:445–449. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Jubb AM, Strickland LA, Liu SD, et al: Neuropilin-1 expression in cancer and development. J Pathol. 226:50–60. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lee SW, Lee JE, Yoo CY, Ko MS, Park CS and Yang S: NRP-1 expression is strongly associated with the progression of pituitary adenomas. Oncol Rep 32: 1537-1542, 2014.
APA
Lee, S.W., Lee, J.E., Yoo, C.Y., Ko, M.S., Park, C.S., & Yang, S. (2014). NRP-1 expression is strongly associated with the progression of pituitary adenomas. Oncology Reports, 32, 1537-1542. https://doi.org/10.3892/or.2014.3392
MLA
Lee, S. W., Lee, J. E., Yoo, C. Y., Ko, M. S., Park, C. S., Yang, S."NRP-1 expression is strongly associated with the progression of pituitary adenomas". Oncology Reports 32.4 (2014): 1537-1542.
Chicago
Lee, S. W., Lee, J. E., Yoo, C. Y., Ko, M. S., Park, C. S., Yang, S."NRP-1 expression is strongly associated with the progression of pituitary adenomas". Oncology Reports 32, no. 4 (2014): 1537-1542. https://doi.org/10.3892/or.2014.3392
Copy and paste a formatted citation
x
Spandidos Publications style
Lee SW, Lee JE, Yoo CY, Ko MS, Park CS and Yang S: NRP-1 expression is strongly associated with the progression of pituitary adenomas. Oncol Rep 32: 1537-1542, 2014.
APA
Lee, S.W., Lee, J.E., Yoo, C.Y., Ko, M.S., Park, C.S., & Yang, S. (2014). NRP-1 expression is strongly associated with the progression of pituitary adenomas. Oncology Reports, 32, 1537-1542. https://doi.org/10.3892/or.2014.3392
MLA
Lee, S. W., Lee, J. E., Yoo, C. Y., Ko, M. S., Park, C. S., Yang, S."NRP-1 expression is strongly associated with the progression of pituitary adenomas". Oncology Reports 32.4 (2014): 1537-1542.
Chicago
Lee, S. W., Lee, J. E., Yoo, C. Y., Ko, M. S., Park, C. S., Yang, S."NRP-1 expression is strongly associated with the progression of pituitary adenomas". Oncology Reports 32, no. 4 (2014): 1537-1542. https://doi.org/10.3892/or.2014.3392
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team