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Review

Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review)

  • Authors:
    • Misuzu Shimakage
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, National Hospital Organization, Wakayama National Hospital, Wakayama 644-0044, Japan
  • Pages: 1763-1771
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    Published online on: September 10, 2014
       https://doi.org/10.3892/or.2014.3475
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Abstract

Epstein-Barr virus (EBV) is a ubiquitous pathogen that was first identified as a human cancer virus. Many human cancers are associated with EBV, and we demonstrated that EBV infects macrophages. Macrophages infected with EBV show a close correlation with many human cancers, and thus more attention must be given to the role of macrophages infiltrating into cancer tissues associated with EBV. In this review, I discuss the role of macrophages in the process of EBV-associated oncogenesis with regard to interleukin-10.
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1 

de Martel, Ferlay J, Franceschi S, Vignat J, Bray F, Forman D and Plummer M: Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 13:607–645. 2012.PubMed/NCBI

2 

Young LS and Murray PG: Epstein-Barr virus and oncogenesis: from latent genes to tumours. Oncogene. 22:5108–5121. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Young LS and Rickinson AB: Epstein-Barr virus: 40 years on. Nat Rev Cancer. 4:757–768. 2004.PubMed/NCBI

4 

Shimakage M, Oka T, Shinka T, Kurata A, Sasagawa T and Yutsudo M: Involvement of Epstein-Barr virus expression in testicular tumors. J Urol. 156:253–257. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Labrecque LG, Barnes DM, Fentiman IS and Griffin BE: Epstein-Barr virus in epithelial cell tumors: A breast cancer study. Cancer Res. 55:39–45. 1995.PubMed/NCBI

6 

Tierney R, Kao K-U, Nagra JK and Rickinson AB: Epstein-Barr virus BamHIW repeat number limits EBNA2/EBNA-LP coexpression in newly infected B cells and the efficiency of B-cell transformation: a rationale for multiple W repeats in wild-type virus strains. J Virol. 85:12363–12375. 2011.

7 

Allan GJ, Inman GJ, Parker BD, Rowe DT and Farrell PJ: Cell growth effects of Epstein-Barr virus leader protein. J Gen Virol. 73:1547–1551. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Peng RS, Moses SC, Tan J, Kremmer E and Ling PD: The Epstein-Barr virus EBNA-LP protein preferentially coactivates EBNA2-mediated stimulation of latent membrane proteins expressed from the viral divergent promoter. J Virol. 79:4492–4505. 2005. View Article : Google Scholar

9 

Shimakage M, Harada S, Kawahara K, Oka T, Yanoma S, Horii K and Sasagawa T: Detection of Epstein-Barr virus nuclear antigen leader protein expression in various human cancers. New Developments in Epstein-Barr Virus Research. Umar S: Nova Science; New York: pp. 261–276. 2006

10 

Portal D, Zhou H, Zhao B, Kharchenko PV, Lowry E, Wong L, Quackenbush J, Holloway D, Jiang S, Lu Y and Kieff E: Epstein-Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2. Proc Natl Acad Sci USA. 110:18537–18542. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Shimakage M, Kurata A, Inoue H, Okamoto Y and Yutsudo M: Tumorigenicity of EBNA2-transfected cells. FEBS Lett. 371:245–248. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Sasagawa T, Shimakage M, Nakamura M, Sakaike J, Ishikawa H and Inoue M: Epstein-Barr virus (EBV) genes expression in cervical intra-epithelial neoplasia and invasive cervical cancer: A comparative study with human papillomavirus (HPV) infection. Hum Pathol. 31:318–326. 2000. View Article : Google Scholar

13 

Pan SH, Tai CC, Lin CS, Hsu WB, Chou SF, Lai CC, Chen JY, Tien HF, Lee FY and Wang WB: Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability. Carcinogenesis. 30:366–375. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Sano H, Nagata K, Kato K, Kanai K, Yamamoto K, Okuno K, Kuwamoto S, Higashi-Mori H, Sugihara H, Kato M, Murakami I, Kanzaki S and Hayashi K: EBNA-2-deleted Epstein-Barr virus from P3HR1 can infect rabbits with lower efficiency than prototype Epstein-Barr virus from B95–8. Intervirology. 56:114–121. 2013.PubMed/NCBI

15 

Wu Y, Maruo S, Yajima M, Kanda T and Takada K: Epstein-Barr virus (EBV)-encoded RNA2 (EBER2) but not EBER1 plays a critical role in EBV-induced B-cell growth transformation. J Virol. 81:11236–11245. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Rosato P, Anastasiadou E, Garg N, Lenze D, Boccellato F, Vincenti S, Severa M, Coccia EM, Bigi R, Cirone M, Ferretti E, Campese AF, et al: Differential regulation of miR-21 and miR-146a by Epstein-Barr virus-encoded EBNA2. Leukemia. 26:2343–2352. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Pfeffer S, Zavolan M, Grasser A, Chien M, Russo J, Ju J, John B, Enright AJ, Marks D, Sander C and Tuschi T: Identification of virus-encoded microRNAs. Science. 304:734–736. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Baichwal VR and Sugden B: Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus. Oncogene. 5:461–467. 1988.PubMed/NCBI

19 

Zheng H, Li L, Hu D, Deng X and Cao Y: Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cell Mol Immunol. 4:185–196. 2007.PubMed/NCBI

20 

Kim K-R, Yoshizaki T, Miyamori H, Hasegawa K, Horikawa T, Furukawa M, Harada S, Seiki M and Sato H: Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus LMP1 induces expression of Ets 1 and invasive growth. Oncogene. 19:1764–1771. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Shair KH, Bendt KM, Edwards RH, Nielsen JN, Moore DT and Raab-Traub N: Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model. J Virol. 86:5352–5365. 2012. View Article : Google Scholar

22 

Swaminathan S, Tomkinson B and Kieff E: Recombinant Epstein-Barr virus with small RNA (EBER) genes deleted transforms lymphocytes and replicates in vitro. Proc Natl Acad Sci USA. 88:1546–1550. 1991. View Article : Google Scholar : PubMed/NCBI

23 

Komano J, Maruo S, Kurozumi K, Oda T and Takada K: Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt’s lymphoma cell line Akata. J Virol. 73:9827–9831. 1999.

24 

Houmani JL, Davis CI and Ruf IK: Growth-promoting properties of Epstein-Barr virus EBER-1 RNA correlates with ribosomal protein L22 binding. J Virol. 83:9844–9853. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Weiss LM and Chen YY: EBER in situ hybridization for Epstein-Barr virus. Meth Mol Biol. 999:223–230. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Shimakage M, Sasagawa T, Yoshino K, Yutsudo M, Kimura M, Yamamoto N and Yanoma S: Expression of Epstein-Barr virus in mesopharyngeal and hypopharyngeal carcinoma. Hum Pathol. 30:3071–3076. 1999. View Article : Google Scholar

27 

Chatani M, Teshima T, Inoue T, Yoshino K, Ikegami N, Hirai K and Shimakage M: Antibody response against the Epstein-Barr virus-coded nuclear antigen 2 (EBNA2) in nasopharyngeal carcinoma. Laryngoscope. 101:626–629. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Shimakage M, Horii K, Tempaku A, Kakudo K, Shirasaka T and Sasagawa T: Association of Epstein-Barr virus with oral cancers. Hum Pathol. 33:608–614. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Shimakage M, Kawahara K, Sasagawa T, Inoue H, Yutsudo M, Yoshida A and Yanoma S: Expression of Epstein-Barr virus in thyroid carcinoma correlates with tumor progression. Hum Pathol. 34:1170–1177. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Shimakage M, Kawahara K, Harada S, Sasagawa T, Shinka T and Oka T: Expression of Epstein-Barr virus in renal cell carcinoma. Oncol Rep. 18:41–46. 2007.PubMed/NCBI

31 

Shimakage M and Sasagawa T: Detection of Epstein-Barr virus-determined nuclear antigen-2 mRNA by in situ hybridization. J Virol Meth. 93:23–32. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Shimakage M, Dezawa T, Tamura S, Tabata T, Aoyagi N, Koike M, Inoue H, Yutsudo M, Hakura A and Ikegami N: A Ki-1-positive cell line expressing Epstein-Barr virus antigens, established from child with Ki-1-positive lymphoma. Intervirology. 36:215–224. 1993.PubMed/NCBI

33 

Shimakage M, Nakamine H, Tamura S, Takenaka T, Yutsudo M and Hakura A: Detection of Epstein-Barr virus transcripts in anaplastic large-cell lymphoma by mRNA in situ hybridization. Hum Pathol. 28:1415–1419. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Shimakage M, Sasagawa T, Kawahara K, Yutsudo M, Kusuoka H and Kozuka T: Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides. Int J Cancer. 92:226–231. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Nakajima H, Shimakage M, Takeda Y, Furutama D, Sugino M, Kimura F, Shibayama Y and Hanafusa T: Epstein-Barr virus-associated primary leptomeningeal lymphoma. Eur J Neurol. 13:e4–e6. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Shimakage M, Sakamaoto H, Harada S, Sasagawa T and Kodama K: Expression of the Epstein-Barr virus in lymphoproliferative diseases of the lung. Oncol Rep. 17:1347–1352. 2007.PubMed/NCBI

37 

Shimakage M, Sasagawa T, Kimura M, Shimakage T, Seto S, Kodama K and Sakamaoto H: Expression of Epstein-Barr virus in Langerhans’ cell histiocytosis. Hum Pathol. 35:862–868. 2004.

38 

Shamaa A, Zyada M, Wagner M, Awad S, Osman MM and Azeem AA: The significance of Epstein-Barr virus (EBV) & DNA topoisomerase II alpha (DNA-topo II alpha) immunoreactivity in normal oral mucosa, oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Diagnostic Pathol. 3:45–57. 2008.

39 

Slots J, Saygun I, Sabeti M and Kubar A: Epstein-Barr virus in oral diseases. J Periodontal Res. 41:235–244. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Jalouli J, Lalouli MM, Sapkota D, Ibrahim SO, Larsson PA and Sand L: Human papilloma virus, herpes simplex virus and Epstein-Barr virus in oral squamous cell carcinoma from eight different countries. Anticancer Res. 32:571–580. 2012.

41 

Szkaradbiewicz A, Kruk-Zagajewska A, Wal M, Jopek M, Wierzbicka A and Kuch A: Epstein-Barr virus and human papillomavirus infections and oropharyngeal squamous cell carcinoma. Clin Exp Med. 2:137–141. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Gonzalez-Moles MA, Gutierrez J, Rodriquez MJ, Ruiz-Avila I and Rodriquez-Archilla A: Epstein-Barr virus latent membrane protein-1 (LMP-1) expression in oral squamous cell carcinoma. Laryngoscope. 112:482–487. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Kobayashi I, Shima K, Saito I, Kiyoshima T, Matsuo K, Ozeki S, Onishi M and Sakai H: Prevalence of Epstein-Barr virus in oral squamous cell carcinoma. J Pathol. 189:34–39. 1999. View Article : Google Scholar : PubMed/NCBI

44 

Herrmann K, Frangou P, Middeldorp J and Niedobitek G: Epstein-Barr virus replication in tongue epithelial cells. J Gen Virol. 83:2995–2998. 2002.PubMed/NCBI

45 

Frangou P, Buettner M and Niedobitek G: Epstein-Barr virus (EBV) infection in epithelial cells in vivo: rare detection of EBV replication in tongue mucosa but not in salivary glands. J Infect Dis. 191:238–242. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Walling DM, Ray AJ, Nichols JE, Flaitz CM and Nichols CM: Epstein-Barr virus infection of Langerhans cell precursors as a mechanism of oral epithelial entry, persistence, and reactivation. J Virol. 81:7249–7268. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Kitahara S, Iitaka M, Shimizu T, Serizawa N, Fukasawa N, Miura S, Kawasaki S, Yamanaka K, Kawakami Y, Murakami S, Ishii J and Katayama S: Thyroid involvement by malignant histiocytosis of Langerhans’ cell type. Clin Endocrinol. 45:357–363. 1996.

48 

Ryder M, Ghossein RA, Ricarte-Filho JCM, Knauf JA and Fagin JA: Increased density of tumor associated macrophages is associated with decreased survival in advanced thyroid cancer. Endocr Relat Cancer. 15:1069–1074. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Liotti F, Visciano C and Melillo RM: Inflammation in thyroid oncogenes. Am J Cancer Res. 2:286–297. 2012.

50 

Kim KH, Han EM, Lee ES, Park HS, Kim I and Kim YS: Epstein-Barr virus infection in sarcomatoid renal cell carcinoma tissues. BJU Int. 96:547–552. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Betge J, Pollheimer MJ, Schelemmer A, Hoefler G and Langner C: Gastric cancer and concomitant renal cancer: A systematic immunohistochemical and molecular analysis. Oncol Rep. 26:567–575. 2011.PubMed/NCBI

52 

Rajpert-De Meyts E, Hørding U, Nielsen HW and Skakkebaek NE: Human papillomavirus and Epstein-Barr virus in the etiology of testicular germ cell tumours. APMIS. 102:38–42. 1994.PubMed/NCBI

53 

Fend F, Hittmair A, Rogatsch H, Gredler E, Obrist P and Mikuz G: Seminomas positive for Epstein-Barr virus by the polymerase chain reaction: viral RNA transcripts (Epstein-Barr-encoded small RNAs) are present in intratumoral lymphocytes but absent from the neoplastic cells. Mod Pathol. 8:622–625. 1995.

54 

Arke O, Lipworth L, Tretli S, Linde A, Engstrand L, Adami HO, Melbye M, Andersen A and Ekbom A: Epstein-Barr virus and cytomegalovirus in relation to testicular-cancer risk: a nested case-control study. Int J Cancer. 82:1–5. 1999. View Article : Google Scholar : PubMed/NCBI

55 

Holl K, Surcel HM, Koskela P, Dillner J, Hallmans G, Wadell G, Kaasila M, Olafsdottir GH, Ogmundsdottir HM, Pukkala E, Stattino P and Lehtinen M: Maternal Epstein-Barr virus and cytomegalovirus infections and risk of testicular cancer in the offspring: a nested case-control study. APMIS. 116:816–822. 2008. View Article : Google Scholar : PubMed/NCBI

56 

Santos NBM, Villanova FE, Andrade PM, Ribalta J, Focchi J, Otsuka AY and Silva ID: Epstein-Barr virus detection in invasive and pre-invasive lesion of the uterine cervix. Oncol Rep. 21:403–405. 2009.PubMed/NCBI

57 

Kim NR, Lin Z, Kim KR, Cho HY and Kim I: Epstein-Barr virus and p16INK4A methylation in squamous cell carcinoma and precancerous lesions of the cervix uteri. J Korean Med Sci. 20:636–642. 2005.PubMed/NCBI

58 

Szostek S, Zawilinska B, Kopec J and Kosz-Vnenchak M: Herpesviruses as possible cofactors in HPV-16-related oncogenesis. Acta Biochimica Pol. 56:337–342. 2009.PubMed/NCBI

59 

Kuze T, Nakamura N, Hashimoto Y, Abe M and Wakasa H: Clinicopathological, immunological and genetic studies of CD30+ anaplastic large cell lymphoma of B-cell type; association with Epstein-Barr virus in Japanese population. J Pathol. 180:236–242. 1996.PubMed/NCBI

60 

Tazzari PL, de Totero D, Bolognesi A, Testoni N, Pileri S, Roncella S, Reato G, Stein H, Gobbi M and Stirpe F: An Epstein-Barr virus-infected lymphoblastoid cell line (D430B) that grows in SCID-mice with the morphologic features of a CD30+ anaplastic large cell lymphoma, and is sensitive to anti-CD30 immunotoxins. Haematologica. 84:988–995. 1999.PubMed/NCBI

61 

Agarwal S, Ramanathan U and Naresh KN: Epstein-Barr virus association and ALK gene expression in anaplastic large-cell lymphoma. Hum Pathol. 33:146–152. 2002. View Article : Google Scholar : PubMed/NCBI

62 

Noorali S, Pervez S, Yaqoob N, Moatter T, Nasir MI, Haroon S, Hodges E and Smith JL: Prevalence and characterization of anaplastic large cell lymphoma and its association with Epstein-Barr virus in Pakistani patients. Pathol Res Pract. 200:669–679. 2004. View Article : Google Scholar : PubMed/NCBI

63 

Kim YC, Yang WI, Lee MG, Kim SN, Cho KH, Lee SL, Lee MW and Koh JK: Epstein-Barr virus on CD30 anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea. Int J Dermatol. 45:1312–1316. 2006. View Article : Google Scholar : PubMed/NCBI

64 

Sasikala PS, Nirmala K, Sundersingh S, Mahli U and Rajkumar T: Frequency and distribution of Epstein-Barr virus infection and its association with p53 expression in a series of primary nodal non-Hodgkin lymphoma patients from South India. Int J Lab Hematol. 32:56–64. 2010. View Article : Google Scholar : PubMed/NCBI

65 

Ma L, Katz Y, Sharan KP, Scwarting R and Kim AS: Epstein-Barr virus positive anaplastic large cell lymphoma: myth or reality? Int J Clin Exp Pathol. 4:100–110. 2011.PubMed/NCBI

66 

Herling M, Rassidakis GZ, Jones D, Schmitt-Graeff A, Sarris AH and Medeiros LJ: Absence of Epstein-Barr virus in anaplastic large cell lymphoma: a study of 64 cases classified according to World Health Organization criteria. Hum Pathol. 35:455–459. 2004. View Article : Google Scholar : PubMed/NCBI

67 

Kasai K, Kon S, Kikuchi K, Sato Y and Kameya T: Expression of carbohydrate antigens, p80NPM/ALK, cytotoxic cell-associated antigens, and Epstein-Barr virus gene products in anaplastic large cell lymphomas. Pathol Int. 48:171–178. 1998. View Article : Google Scholar : PubMed/NCBI

68 

Lopategui JR, Gaffey MJ, Chan JK, Fierson HF, Sun LH, Bellafiore FJ, Chang KL and Weiss LM: Infrequent association of Epstein-Barr virus with CD30-positive anaplastic large cell lymphomas from American and Asian patients. Am J Surg Pathol. 19:42–49. 1995. View Article : Google Scholar : PubMed/NCBI

69 

Hellier I, Dereure O, Segondy M, Guillot B, Baldet P and Guilhou JJ: Unlikely role of Epstein-Barr virus in the pathogenesis of primary cutaneous CD30+ anaplastic large cell lymphoma. Eur J Dermatol. 11:203–208. 2001.PubMed/NCBI

70 

Park CK and Ko YH: Detection of EBER nuclear RNA in T-cell lymphoma involving the skin - an in situ hybridization study. Br J Dermatol. 134:488–493. 1996. View Article : Google Scholar : PubMed/NCBI

71 

Erkek E, Sahin S, Atakan N, Kokagoz T, Olut A and Goköz A: Examination of mycosis fungoides for the presence of Epstein-Barr virus and human herpesvirus-6 by polymerase chain reaction. J Eur Acad Dermatol Venereol. 15:422–426. 2001. View Article : Google Scholar : PubMed/NCBI

72 

Novelli M, Merlino C, Ponti R, Bergallo M, Quaglino P, Cambien I, Comessatti A, Sidoti F, Costa C, Corino D, Cavallo R, Ponzi AN, Fierro MT and Bernengo MG: Epstein-Barr virus in cutaneous T-cell lymphomas: evaluation of the viral presence and significance in skin and peripheral blood. J Invest Dermatol. 129:1556–1561. 2009. View Article : Google Scholar : PubMed/NCBI

73 

Copur MS, Deshpande A, Mleczko K, Norvell M, Hernicek GJ, Woodward S, Frankforter S, Mandolfo N, Fu K and Chan WC: Full clinical recovery after topical treatment of Epstein-Barr virus associated cutaneous B-cell lymphoma in patient with mycosis fungoides. Croat Med J. 46:458–462. 2005.PubMed/NCBI

74 

Jeziorski E, Senechal B, Molina TJ, Devez F, Leruez-Ville M, Morand P, Glorion C, Mansuy L, Gaudelus J, Debre M, Jaubert F, Seigneurin J-M, Thomas C, Joab I, Donadieu J and Geissmann F: Herpesvirus infection in patients with Langerhans cell histiocytosis: a case-controlled sero-epidemiological study, and in situ analysis. PLos One. 3:e32622008. View Article : Google Scholar : PubMed/NCBI

75 

Csire M, Mikala G, Jako J, Masszi T, Janosi J, Dolgos J, Fule J, Tordai A, Berencsi G and Valyi-Nagy I: Persistent long-term human herpesvirus 6 (HHV-6) infection in a patient with Langerhans cell histiocytosis. Pathol Oncol Res. 13:157–160. 2007. View Article : Google Scholar : PubMed/NCBI

76 

Sakata N, Toguchi N, Kimura M, Nakayama M, Kawa K and Takemura T: Development of Langerhans cell histiocytosis associated with chronic active Epstein-Barr virus infection. Pediatr Blood Cancer. 50:924–927. 2008. View Article : Google Scholar : PubMed/NCBI

77 

Feng WH, Bruce I, Raab-Traub N, Busson P and Kenney SC: Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Res. 62:1920–1926. 2002.PubMed/NCBI

78 

Huang J, Chen H, Hutt-Fletcher L, Ambinder F and Hayward SD: Lytic viral replication as a contributor to the detection of Epstein-Barr virus in breast cancer. J Virol. 77:13267–13274. 2003. View Article : Google Scholar : PubMed/NCBI

79 

Lee CH, Yeh TH, Lai HC, Wu SY, Su IJ, Takada K and Chang Y: Epstein-Barr virus Zta-induced immunomodulators from nasopharyngeal carcinoma cells upregulate interleukin-10 production from monocytes. J Virol. 85:7333–7342. 2011. View Article : Google Scholar

80 

Murata T and Tsurumi T: Epigenetic modification of the Epstein-Barr virus BZLF1 promoter regulates viral reactivation from latency. Front Genet. 4:532013. View Article : Google Scholar : PubMed/NCBI

81 

Shimakage M, Miyata Y, Inoue H, Yutsudo M and Hakura A: Increased sensitivity of EBNA2-transformed rat fibroblasts to ionizing radiation. Int J Cancer. 68:612–615. 1996. View Article : Google Scholar : PubMed/NCBI

82 

Wang ZY, Liu QF, Wang H, Jin J, Wang WH, Wang SL, Song YW, Liu YP, Fang H, Ren H, Wu RY, Chen B, Zhang XM, Lu NN, Zhou LQ and Li YX: Clinical implications of plasma Epstein-Barr virus DNA in early-stage extranodal nasal-type NK/T-cell lymphoma patients receiving primary radiotherapy. Blood. 10:2003–2010. 2012. View Article : Google Scholar

83 

Thomas TO, Agrawal P, Guitart J, Rosen ST, Rademaker AW, Querfeld C, Heyes JP, Kuzal TM and Mittal BB: Outcome of patients treated with a single-fraction dose of palliative radiation for cutaneous T-cell lymphoma. Int J Radiat Oncol Biol Phys. 85:747–753. 2013. View Article : Google Scholar : PubMed/NCBI

84 

Shimakage M, Kimura M, Yanoma S, Ibe M, Yokota S, Tsujino G, Kozuka T, Dezawa T, Tamura S, Ohshima A, Yutsudo M and Hakura A: Expression of latent and replicative-infection genes of Epstein-Barr virus in macrophages. Arch Virol. 144:157–166. 1999. View Article : Google Scholar : PubMed/NCBI

85 

Masy E, Adriaenssens E, Montepellier C, Crepieux P, Mougel A, Quatannens B, Goormachtigh G, Faumont N, Meggetto F, Auriault C, Groux H and Coll J: Human monocytic cell lines transformed in vitro by Epstein-Barr virus type II latency and LMP-1-dependent proliferation. J Virol. 76:6460–6472. 2002. View Article : Google Scholar : PubMed/NCBI

86 

Salek-Ardakani S, Lyons SA and Arrand JR: Epstein-Barr virus promotes human monocyte survival and mutation through a paracrine induction of IFN-alpha. J Immunol. 173:321–331. 2004. View Article : Google Scholar : PubMed/NCBI

87 

Tugizov S, Herrara R, Veluppillai P, Greenspan D and Palefsky JM: Epstein-Barr virus (EBV)-infected monocytes facilitate dissemination of EBV within the oral mucosal epithelium. J Virol. 81:5484–5496. 2007. View Article : Google Scholar : PubMed/NCBI

88 

Li H, Ikuta K, Sixbey JW and Tibbetts SA: A replication-defective gammaherpesvirus efficiency establishes long-term latency in macrophages but not in B cells in vivo. J Virol. 82:8500–8508. 2008. View Article : Google Scholar : PubMed/NCBI

89 

Hwang KK, Chen X, Kozink DM, Gustilo M, Marshall DJ, Whitesides JF, Liao XH, Catera R, Chu CC, Yan XJ, Luftig MA, Haynes GF and Chiorazzi N: Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells. Blood. 119:e35–e44. 2012. View Article : Google Scholar : PubMed/NCBI

90 

Andereesen R, Grugger W, Lohr GW and Bross KJ: Human macrophages can express the Hodgkin’s cell-associated antigen Ki-1 (CD30). Am J Pathol. 134:187–192. 1989.

91 

Balkwill F and Mantovani A: Inflammation and cancer: back to Virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI

92 

Qian BZ and Pollard JW: Macrophage diversity enhances tumor progression and metastasis. Cell. 141:39–50. 2010. View Article : Google Scholar : PubMed/NCBI

93 

Biswas SK and Mantovani A: Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 11:889–896. 2010. View Article : Google Scholar : PubMed/NCBI

94 

Mantovani A: B cells and macrophages in cancer: yin and yang. Nat Med. 17:285–286. 2011. View Article : Google Scholar : PubMed/NCBI

95 

Hamada I, Kato M, Yamasaki T, Iwabuchi K, Watanabe T, Yamada T, Itoyama S, Ito H and Okada K: Clinical effects of tumor-associated macrophages and dendritic cells on renal cell carcinoma. Anticancer Res. 22:4281–4284. 2002.PubMed/NCBI

96 

Komohara Y, Hasita H, Ohnishi K, Fujiwara Y, Suzu S, Eto M and Takeya M: Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma. Cancer Sci. 102:1424–1431. 2011. View Article : Google Scholar : PubMed/NCBI

97 

Liou P, Bader L, Wang A, Yamashiro D and Kandel J: Correlation of tumor-associated macrophages and clinicopathological factors in Wilms tumor. Vasc Cell. 5:52013. View Article : Google Scholar : PubMed/NCBI

98 

Shimakage M and Sakamoto H: Macrophage involvement in Epstein-Barr virus-related tumors. Exp Ther Med. 1:285–291. 2010. View Article : Google Scholar : PubMed/NCBI

99 

Thorley-Lawson DA: EBV the prototypical human tumor virus - just how bad is it? J Allergy Clin Immunol. 116:251–261. 2005. View Article : Google Scholar : PubMed/NCBI

100 

Vieira P, de Waal-Malefyt R, Dang MN, Johnson KE, Kastelein R, Fiorentino DF, DeVries JE, Roncarolo MG, Mosmann TR and Moore KW: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRF1. Proc Natl Acad Sci USA. 88:1172–1176. 1991. View Article : Google Scholar

101 

Miyazakai I, Cheung RK and Dosch H-M: Viral interleukin 10 is critical for the induction of B cell growth transformation by Epstein-Barr virus. J Exp Med. 178:439–447. 1993. View Article : Google Scholar : PubMed/NCBI

102 

Hsu DH, de Waal Malefyt R, Fierentino DF, Dang MN, Vieira P, DeVries V, Spits H, Mosmann TR and Moore KW: Expression of interkeukin-10 activity by Epstein-Barr virus protein BCRF1. Science. 250:830–832. 1990. View Article : Google Scholar : PubMed/NCBI

103 

Jochum S, Moosmann A, Lang S, Hammerschmidt W and Zeidler R: The EBV immunoevasins vIL-10 and BNLF2a protect newly infected B cells from immune recognition and elimination. PLoS Pathog. 5:e10027042012. View Article : Google Scholar : PubMed/NCBI

104 

de Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C, Johnson K, Yssel H and de Vries JE: Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med. 174:915–924. 1991.

105 

Sica A, Allavena P and Mantovani A: Cancer related inflammation: The macrophage connection. Cancer Lett. 264:204–215. 2008. View Article : Google Scholar

106 

Suzuki T, Tahara H, Narula S, Moore KW, Robbins P and Lotze MT: Viral interleukin 10 (IL-10), the human herpesvirus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors. J Exp Med. 182:477–486. 1995. View Article : Google Scholar : PubMed/NCBI

107 

Kanai K, Satoh Y, Yamanaka H, Kawaguchi A, Horie K, Hoshikawa Y, Sata T and Sairenji T: The vIL-10 gene of the Epstein-Barr virus (EBV) is conserved in a stable manner except for a few point mutations in various EBV isolates. Virus Genes. 35:563–569. 2007. View Article : Google Scholar : PubMed/NCBI

108 

Chao Y, Jing Y, Jia Y, Wang Y, Zhao C and Luo B: Conservation and mutation of viral interleukin-10 gene in gastric carcinomas and nasopharyngeal carcinomas. J Med Virol. 83:644–650. 2011. View Article : Google Scholar : PubMed/NCBI

109 

Lee JH, Lee GT, Woo SH, Ha YS, Kwon SJ, Kim WJ and Kim IY: BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages. Cancer Res. 73:3604–3614. 2013. View Article : Google Scholar : PubMed/NCBI

110 

Ghosh SK, Perrine S and Faller DV: Advances in virus-directed therapeutics against Epstein-Barr virus-associated malignancies. Adv Virol. Mar 5–2012.(Epub ahead of print). View Article : Google Scholar

111 

Feng WH, Israel B, Raab-Traub N, Busson P and Kenney SC: Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Res. 62:1920–1926. 2002.PubMed/NCBI

112 

Fu DX, Tanhehco Y, Chen J, Foss CA, Fox JJ, Chong JM, Hobbs RF, Fukayama M, Sgouros G, Kowalski J, Pomper MG and Ambinder RF: Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors. Nat Med. 14:1118–1122. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shimakage M: Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review). Oncol Rep 32: 1763-1771, 2014.
APA
Shimakage, M. (2014). Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review). Oncology Reports, 32, 1763-1771. https://doi.org/10.3892/or.2014.3475
MLA
Shimakage, M."Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review)". Oncology Reports 32.5 (2014): 1763-1771.
Chicago
Shimakage, M."Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review)". Oncology Reports 32, no. 5 (2014): 1763-1771. https://doi.org/10.3892/or.2014.3475
Copy and paste a formatted citation
x
Spandidos Publications style
Shimakage M: Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review). Oncol Rep 32: 1763-1771, 2014.
APA
Shimakage, M. (2014). Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review). Oncology Reports, 32, 1763-1771. https://doi.org/10.3892/or.2014.3475
MLA
Shimakage, M."Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review)". Oncology Reports 32.5 (2014): 1763-1771.
Chicago
Shimakage, M."Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review)". Oncology Reports 32, no. 5 (2014): 1763-1771. https://doi.org/10.3892/or.2014.3475
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