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December-2014 Volume 32 Issue 6

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Article

SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis

  • Authors:
    • Li Lin
    • Xiaoxia Zheng
    • Chunping Qiu
    • Samina Dongol
    • Qingtao Lv
    • Jie Jiang
    • Beihua Kong
    • Chenguang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, P.R. China, Department of Obstetrics and Gynecology, Jinan Maternity and Child Care Hospital, Jinan, P.R. China, Department of Pharmaceutical Chemistry, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, P.R. China, Departments of Cancer Biology, Stem Cell Biology and Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
  • Pages: 2831-2835
    |
    Published online on: October 1, 2014
       https://doi.org/10.3892/or.2014.3521
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Abstract

Silent information regulator 1 (SIRT1) is involved in a number of cellular regulatory mechanisms affecting cellular life span, stress resistance, apoptosis and cellular metabolism. Recent studies have revealed that SIRT1 plays a dual role as a tumor suppressor and a tumor promoter in multiple stages of carcinogenesis. Increased lipogenesis has been found in cancer cells, sterol regulatory element binding protein 1 (SREBP1) are nuclear lipogenic transcription factors, which mainly regulate lipogenic processes by activating genes involved in fatty acid and triglyceride biosynthesis. In the present study, we detected expression of SIRT1 in endometrial cancer (EC) and illustrated the relationship between SIRT1 and SREBP1, which indicated that SIRT1 could stimulate endometrial tumor growth through the lipogenic pathway. Gene expression levels of SIRT1 were assayed using quantitative real-time PCR and protein expression levels were detected by western blotting. RNA interference was conducted in order to explore the subsequent effect on tumor cells and on the expression of SREBP1. Expression levels of SIRT1 in EC were found to be significantly higher than in normal endometrium. Knockdown of SIRT1 could downregulate expression of SREBP1 and suppress cell proliferation. These results demonstrated that SIRT1 may play a role as a tumor promoter in EC and can promote endometrial tumor growth by promoting lipogenesis. Our findings suggest that targeting SIRT1 may provide a theoretical basis for the management of EC.
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Copy and paste a formatted citation
Spandidos Publications style
Lin L, Zheng X, Qiu C, Dongol S, Lv Q, Jiang J, Kong B and Wang C: SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. Oncol Rep 32: 2831-2835, 2014.
APA
Lin, L., Zheng, X., Qiu, C., Dongol, S., Lv, Q., Jiang, J. ... Wang, C. (2014). SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. Oncology Reports, 32, 2831-2835. https://doi.org/10.3892/or.2014.3521
MLA
Lin, L., Zheng, X., Qiu, C., Dongol, S., Lv, Q., Jiang, J., Kong, B., Wang, C."SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis". Oncology Reports 32.6 (2014): 2831-2835.
Chicago
Lin, L., Zheng, X., Qiu, C., Dongol, S., Lv, Q., Jiang, J., Kong, B., Wang, C."SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis". Oncology Reports 32, no. 6 (2014): 2831-2835. https://doi.org/10.3892/or.2014.3521
Copy and paste a formatted citation
x
Spandidos Publications style
Lin L, Zheng X, Qiu C, Dongol S, Lv Q, Jiang J, Kong B and Wang C: SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. Oncol Rep 32: 2831-2835, 2014.
APA
Lin, L., Zheng, X., Qiu, C., Dongol, S., Lv, Q., Jiang, J. ... Wang, C. (2014). SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. Oncology Reports, 32, 2831-2835. https://doi.org/10.3892/or.2014.3521
MLA
Lin, L., Zheng, X., Qiu, C., Dongol, S., Lv, Q., Jiang, J., Kong, B., Wang, C."SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis". Oncology Reports 32.6 (2014): 2831-2835.
Chicago
Lin, L., Zheng, X., Qiu, C., Dongol, S., Lv, Q., Jiang, J., Kong, B., Wang, C."SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis". Oncology Reports 32, no. 6 (2014): 2831-2835. https://doi.org/10.3892/or.2014.3521
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