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Article

Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression

  • Authors:
    • Xiulan Zhao
    • Baocun Sun
    • Dan Sun
    • Tieju Liu
    • Na Che
    • Qiang Gu
    • Xueyi Dong
    • Rui Li
    • Yanrong Liu
    • Jing Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Tianjin Medical University, Tianjin 300052, P.R. China
  • Pages: 149-156
    |
    Published online on: October 22, 2014
       https://doi.org/10.3892/or.2014.3562
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Abstract

Transcription factor Slug plays an important role in the tumor invasion and metastasis of human hepatocellular carcinoma (HCC). This study aimed to explore the mechanism involved in the promotion of HCC progression by Slug. In the precent study, we demonstrated that Slug expression was significantly associated with metastasis and shorter survival time of HCC patients. Using ChIP-on-chip and microarray analysis, we identified the molecular profile of Slug downstream targets in HCC cells with Slug overexpression. The Wnt, Notch and Hedgehog pathways were identified to promote pluripotency maintaining overexpression factors sox2 and nanog. Importantly, Slug showed a close relationship with sox2 and nanog expression in HCC patients and in HCC xenografts in vivo. Notably, the DNA damaging reagent hydroxyurea had no effect on Slug, sox2 and nanog expression in HCC cells with Slug overexpression; however knockdown of Slug by the short hairpin RNA approach markedly reduced sox2 and nanog expression and inhibited HCC cell migration in vitro. The results of this study indicate that Slug promotes progression of HCC by promoting sox2 and nanog overexpression. The related molecular pathways may be used as novel therapeutic targets for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Sun B, Sun D, Liu T, Che N, Gu Q, Dong X, Li R, Liu Y, Li J, Li J, et al: Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression. Oncol Rep 33: 149-156, 2015.
APA
Zhao, X., Sun, B., Sun, D., Liu, T., Che, N., Gu, Q. ... Li, J. (2015). Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression. Oncology Reports, 33, 149-156. https://doi.org/10.3892/or.2014.3562
MLA
Zhao, X., Sun, B., Sun, D., Liu, T., Che, N., Gu, Q., Dong, X., Li, R., Liu, Y., Li, J."Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression". Oncology Reports 33.1 (2015): 149-156.
Chicago
Zhao, X., Sun, B., Sun, D., Liu, T., Che, N., Gu, Q., Dong, X., Li, R., Liu, Y., Li, J."Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression". Oncology Reports 33, no. 1 (2015): 149-156. https://doi.org/10.3892/or.2014.3562
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Sun B, Sun D, Liu T, Che N, Gu Q, Dong X, Li R, Liu Y, Li J, Li J, et al: Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression. Oncol Rep 33: 149-156, 2015.
APA
Zhao, X., Sun, B., Sun, D., Liu, T., Che, N., Gu, Q. ... Li, J. (2015). Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression. Oncology Reports, 33, 149-156. https://doi.org/10.3892/or.2014.3562
MLA
Zhao, X., Sun, B., Sun, D., Liu, T., Che, N., Gu, Q., Dong, X., Li, R., Liu, Y., Li, J."Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression". Oncology Reports 33.1 (2015): 149-156.
Chicago
Zhao, X., Sun, B., Sun, D., Liu, T., Che, N., Gu, Q., Dong, X., Li, R., Liu, Y., Li, J."Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression". Oncology Reports 33, no. 1 (2015): 149-156. https://doi.org/10.3892/or.2014.3562
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