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Article

Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo

Retraction in: /10.3892/or.2021.8125
  • Authors:
    • Qi Zhang
    • Weiqun Yan
    • Yang Bai
    • Hao Xu
    • Changhao Fu
    • Wenwen Zheng
    • Yingqiao Zhu
    • Jie Ma
  • View Affiliations / Copyright

    Affiliations: School of Pharmaceutical Sciences, Jilin University, Jilin, P.R. China, First Hospital of Jilin University, Jilin, P.R. China, Institute of Virology and AIDS Research, First Hospital of Jilin University, Jilin, P.R. China
  • Pages: 448-456
    |
    Published online on: November 5, 2014
       https://doi.org/10.3892/or.2014.3591
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Abstract

Multiple myeloma (MM) is a disease with an adverse outcome and new therapeutic strategies are required to combat this disease. It is well known that tumor‑suppressor microRNA (miRNA) acts as a new potential anticancer agent. Accumulating evidence showed that microRNA-145 (miR-145) is a candidate tumor suppressor miRNA. However, whether miR-145 is involved in the development and progression of MM reamins to be determined. In the present study, we investigated the therapeutic potential of synthetic miR-145 against human MM cells in vitro and in vivo. The results showed that miR-145 was reduced in MM tissues and cell lines. Enforced expression of miR-145 by transfection with miR-145 mimics inhibited cell proliferation, migration, and the invasion abilities of H929 cells. Furthermore, our results demonstrated that the enforced expression of miR-145 in H929 cells profoundly decreased the levels of p-AKT and p-PI3K, which may contribute to some extent to the inhibition of MM cell proliferation and survival. The enforced expression of miR-145 in a xenograft mouse model suppressed tumor growth. In conclusion, our findings suggested that miR-145 may act as a tumor suppressor and contributes to the progression of MM. Additionally, miR-145 mimics is a potential therapeutic agent for the treatment of MM.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Yan W, Bai Y, Xu H, Fu C, Zheng W, Zhu Y and Ma J: Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125. Oncol Rep 33: 448-456, 2015.
APA
Zhang, Q., Yan, W., Bai, Y., Xu, H., Fu, C., Zheng, W. ... Ma, J. (2015). Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125. Oncology Reports, 33, 448-456. https://doi.org/10.3892/or.2014.3591
MLA
Zhang, Q., Yan, W., Bai, Y., Xu, H., Fu, C., Zheng, W., Zhu, Y., Ma, J."Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125". Oncology Reports 33.1 (2015): 448-456.
Chicago
Zhang, Q., Yan, W., Bai, Y., Xu, H., Fu, C., Zheng, W., Zhu, Y., Ma, J."Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125". Oncology Reports 33, no. 1 (2015): 448-456. https://doi.org/10.3892/or.2014.3591
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Yan W, Bai Y, Xu H, Fu C, Zheng W, Zhu Y and Ma J: Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125. Oncol Rep 33: 448-456, 2015.
APA
Zhang, Q., Yan, W., Bai, Y., Xu, H., Fu, C., Zheng, W. ... Ma, J. (2015). Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125. Oncology Reports, 33, 448-456. https://doi.org/10.3892/or.2014.3591
MLA
Zhang, Q., Yan, W., Bai, Y., Xu, H., Fu, C., Zheng, W., Zhu, Y., Ma, J."Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125". Oncology Reports 33.1 (2015): 448-456.
Chicago
Zhang, Q., Yan, W., Bai, Y., Xu, H., Fu, C., Zheng, W., Zhu, Y., Ma, J."Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125". Oncology Reports 33, no. 1 (2015): 448-456. https://doi.org/10.3892/or.2014.3591
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