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Article

HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2

  • Authors:
    • Yuehui Li
    • Xiao Hui Yang
    • Shu Juang Fang
    • Chang Fei Qin
    • Rui Li Sun
    • Zhao Yang Liu
    • Bin Yuan Jiang
    • Xiang Wu
    • Guancheng Li
  • View Affiliations / Copyright

    Affiliations: Tumor Immunobiology Laboratory of the Cancer Research Institute, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Key Laboratory of Carcinogenesis, Ministry of Health, Central South University, Changsha, Hunan, P.R. China, Xiangya Third Hospital, Central South University, Changsha, Hunan, P.R. China
  • Pages: 990-996
    |
    Published online on: December 11, 2014
       https://doi.org/10.3892/or.2014.3668
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Abstract

HOX genes are transcription factors that control morphogenesis, organogenesis and differentiation. Increasing evidence suggests that HOX genes play a role in hepatocellular carcinoma (HCC) progression; however few studies have defined the functional roles and mechanisms of action. In the present study, we used siRNA and forced-expression in multiple cell lines to define the role of HOXA7 in the regulation of proliferation of HCC in vitro and in vivo. Knockdown of endogenous HOXA7 decreased the proliferation of HepG2 and QGY-7703 cells. These changes were not associated with significant changes in cyclin D1 and CDK4. However, downregulation of HOXA7 significantly reduced cyclin E1 and CDK2 protein levels. Conversely, overexpression of HOXA7 in QSG-7701 cells stimulated proliferation and increased cyclin E1 and CDK2 protein levels. Our results confirmed that HOXA7 promoted cell proliferation, and these changes were mediated by cyclin E1/CDK2. These observations contribute to our understanding of the important roles of HOXA7 in HCC development and progression and HOXA7 could be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Yang XH, Fang SJ, Qin CF, Sun RL, Liu ZY, Jiang BY, Wu X and Li G: HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2. Oncol Rep 33: 990-996, 2015.
APA
Li, Y., Yang, X.H., Fang, S.J., Qin, C.F., Sun, R.L., Liu, Z.Y. ... Li, G. (2015). HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2. Oncology Reports, 33, 990-996. https://doi.org/10.3892/or.2014.3668
MLA
Li, Y., Yang, X. H., Fang, S. J., Qin, C. F., Sun, R. L., Liu, Z. Y., Jiang, B. Y., Wu, X., Li, G."HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2". Oncology Reports 33.2 (2015): 990-996.
Chicago
Li, Y., Yang, X. H., Fang, S. J., Qin, C. F., Sun, R. L., Liu, Z. Y., Jiang, B. Y., Wu, X., Li, G."HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2". Oncology Reports 33, no. 2 (2015): 990-996. https://doi.org/10.3892/or.2014.3668
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Yang XH, Fang SJ, Qin CF, Sun RL, Liu ZY, Jiang BY, Wu X and Li G: HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2. Oncol Rep 33: 990-996, 2015.
APA
Li, Y., Yang, X.H., Fang, S.J., Qin, C.F., Sun, R.L., Liu, Z.Y. ... Li, G. (2015). HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2. Oncology Reports, 33, 990-996. https://doi.org/10.3892/or.2014.3668
MLA
Li, Y., Yang, X. H., Fang, S. J., Qin, C. F., Sun, R. L., Liu, Z. Y., Jiang, B. Y., Wu, X., Li, G."HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2". Oncology Reports 33.2 (2015): 990-996.
Chicago
Li, Y., Yang, X. H., Fang, S. J., Qin, C. F., Sun, R. L., Liu, Z. Y., Jiang, B. Y., Wu, X., Li, G."HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2". Oncology Reports 33, no. 2 (2015): 990-996. https://doi.org/10.3892/or.2014.3668
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