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Article

Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells

  • Authors:
    • Ya Ding
    • Wenjun Zhu
    • Rui Sun
    • Gang Yuan
    • Dongsheng Zhang
    • Yuhua Fan
    • Jian Sun
  • View Affiliations / Copyright

    Affiliations: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P.R. China, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, P.R. China, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, P.R. China
  • Pages: 1434-1442
    |
    Published online on: January 15, 2015
       https://doi.org/10.3892/or.2015.3726
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Abstract

Infection with Epstein-Barr virus (EBV) and its encoded latent membrane protein 1 (LMP1) play oncogenic roles in Burkitt's lymphoma (BL). Flow cytometry was used to measure cellular reactive oxygen species (ROS) concentrations, and cellular lactate generation and diphenylene iodonium (DPI) cytotoxicity were determined by analyzing lactate concentrations and cell viability. We also measured NAD(P)H oxidase (NOX) activity. Reverse transcriptase PCR and qPCR assays were used to analyze LMP1 levels, and protein expression was measured by immunoblotting. In the present study, EBV was able to induce NOX activity and ROS generation in the BL cells. Inhibition of NOX activity by DPI suppressed ROS levels and elevated lactate levels. DPI treatment first resulted in a G2-M phase cell cycle arrest and then induced significant apoptosis. Immunoblot analysis demonstrated that DPI suppressed the expression of c-Myc and Cdc25A within 6 h, which may have caused the cell cycle arrest. Collectively, these findings indicate a close relationship between EBV infection and NOX activation, permitting a deeper understanding of ROS inhibition in cell cycle regulation and providing a novel therapeutic target for BL treatment.
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1 

Vereide DT, Seto E, Chiu YF, Hayes M, Tagawa T, Grundhoff A, Hammerschmidt W and Sugden B: Epstein-Barr virus maintains lymphomas via its miRNAs. Oncogene. 33:1258–1264. 2014. View Article : Google Scholar

2 

Bornkamm GW: Epstein-Barr virus and the pathogenesis of Burkitt’s lymphoma: more questions than answers. Int J Cancer. 124:1745–1755. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T and Bailey S: Burkitt’s lymphoma. Lancet. 379:1234–1244. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Drexler HG and Minowada J: History and classification of human leukemia-lymphoma cell lines. Leuk Lymphoma. 31:305–316. 1998.PubMed/NCBI

5 

Bieging KT, Amick AC and Longnecker R: Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis. Proc Natl Acad Sci USA. 106:17945–17950. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Lassoued S, Ben Ameur R, Ayadi W, Gargouri B, Ben Mansour R and Attia H: Epstein-Barr virus induces an oxidative stress during the early stages of infection in B lymphocytes, epithelial, and lymphoblastoid cell lines. Mol Cell Biochem. 313:179–186. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Cerimele F, Battle T, Lynch R, Frank DA, Murad E, Cohen C, Macaron N, Sixbey J, Smith K, Watnick RS, Eliopoulos A, Shehata B and Arbiser JL: Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt’s lymphoma. Proc Natl Acad Sci USA. 102:175–179. 2005. View Article : Google Scholar

8 

Zheng H, Li LL, Hu DS, Deng XY and Cao Y: Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cell Mol Immunol. 4:185–196. 2007.PubMed/NCBI

9 

Ha YJ and Lee JR: Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidase. J Immunol. 172:231–239. 2004. View Article : Google Scholar

10 

Lambeth JD, Kawahara T and Diebold B: Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med. 43:319–331. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Devi GS, Prasad MH, Saraswathi I, Raghu D, Rao DN and Reddy PP: Free radicals antioxidant enzymes and lipid peroxidation in different types of leukemias. Clin Chim Acta. 293:53–62. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Park SY, Chang I, Kim JY, Kang SW, Park SH, Singh K and Lee MS: Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase. J Biol Chem. 279:7512–7520. 2004. View Article : Google Scholar

13 

Behrend L, Henderson G and Zwacka RM: Reactive oxygen species in oncogenic transformation. Biochem Soc Trans. 31:1441–1444. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Roth D, Krammer PH and Gulow K: Dynamin related protein 1-dependent mitochondrial fission regulates oxidative signalling in T cells. FEBS Lett. 588:1749–1754. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J and Huang P: Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate. Cancer Cell. 10:241–252. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Lin B, Chen Z, Xu Y, Zhang H, Liu J and Qian X: 7-b, a novel amonafide analogue, cause growth inhibition and apoptosis in Raji cells via a ROS-mediated mitochondrial pathway. Leuk Res. 35:646–656. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Fengling M, Fenju L, Wanxin W, Lijia Z, Jiandong T, Zu W, Xin Y and Qingxiang G: Rituximab sensitizes a Burkitt lymphoma cell line to cell killing by X-irradiation. Radiat Environ Biophys. 48:371–378. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Kuang Y, Balakrishnan K, Gandhi V and Peng X: Hydrogen peroxide inducible DNA cross-linking agents: targeted anti-cancer prodrugs. J Am Chem Soc. 133:19278–19281. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Fang J, Nakamura H and Iyer AK: Tumor-targeted induction of oxystress for cancer therapy. J Drug Target. 15:475–486. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Hu ZY, Wang J, Cheng G, Zhu XF, Huang P, Yang D and Zeng YX: Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species. Chin J Cancer. 30:41–53. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Acharya A, Das I, Chandhok D and Saha T: Redox regulation in cancer: a double-edged sword with therapeutic potential. Oxid Med Cell Longev. 3:23–34. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Lee KW and Lee HJ: The roles of polyphenols in cancer chemoprevention. Biofactors. 26:105–121. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Roy P, George J, Srivastava S, Tyagi S and Shukla Y: Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors. Invest New Drugs. 29:225–231. 2011. View Article : Google Scholar

24 

Talero E, Ávila-Roman J and Motilva V: Chemoprevention with phytonutrients and microalgae products in chronic inflammation and colon cancer. Curr Pharm Des. 18:3939–3965. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Yamaura M, Mitsushita J, Furuta S, Kiniwa Y, Ashida A, Goto Y, Shang WH, Kubodera M, Kato M, Takata M, Saida T and Kamata T: NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression. Cancer Res. 69:2647–2654. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Bedard K and Krause KH: The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 87:245–313. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Mbulaiteye SM, Anderson WF, Ferlay J, Bhatia K, Chang C, Rosenberg PS, Devesa SS and Parkin DM: Pediatric, elderly, and emerging adult-onset peaks in Burkitt’s lymphoma incidence diagnosed in four continents, excluding Africa. Am J Hematol. 87:573–578. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Gu JM, Lim SO, Oh SJ, Yoon SM, Seong JK and Jung G: HBx modulates iron regulatory protein 1-mediated iron metabolism via reactive oxygen species. Virus Res. 133:167–177. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Silic-Benussi M, Cavallari I, Vajente N, Vidali S, Chieco-Bianchi L, Di Lisa F, Saggioro D, D’Agostino DM and Ciminale V: Redox regulation of T-cell turnover by the p13 protein of human T-cell leukemia virus type 1: distinct effects in primary versus transformed cells. Blood. 116:54–62. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Hutzinger R, Feederle R, Mrazek J, Schiefermeier N, Balwierz PJ, Zavolan M, Polacek N, Delecluse HJ and Hüttenhofer A: Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome. PLoS Pathog. 5:e10005472009. View Article : Google Scholar : PubMed/NCBI

31 

Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y and Huang P: Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol. 10:e10013262012. View Article : Google Scholar : PubMed/NCBI

32 

Prata C, Maraldi T, Fiorentini D, Zambonin L, Hakim G and Landi L: Nox-generated ROS modulate glucose uptake in a leukaemic cell line. Free Radic Res. 42:405–414. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Han CY, Umemoto T, Omer M, Den Hartigh LJ, Chiba T, LeBoeuf R, Buller CL, Sweet IR, Pennathur S, Abel ED and Chait A: NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. J Biol Chem. 287:10379–10393. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Block K and Gorin Y: Aiding and abetting roles of NOX oxidases in cellular transformation. Nat Rev Cancer. 12:627–637. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Mochizuki T, Furuta S, Mitsushita J, Shang WH, Ito M, Yokoo Y, Yamaura M, Ishizone S, Nakayama J, Konagai A, Hirose K, Kiyosawa K and Kamata T: Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene. 25:3699–3707. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Singh MM, Irwin ME, Gao Y, Ban K, Shi P, Arlinghaus RB, Amin HM and Chandra J: Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia. Cancer. 118:3433–3445. 2012. View Article : Google Scholar :

37 

Ding Y, Chen ZJ, Liu S, Che D, Vetter M and Chang CH: Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone. J Pharm Pharmacol. 57:111–116. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Gianni D, Taulet N, Zhang H, Der Mardirossian C, Kister J, Martinez L, Roush WR, Brown SJ, Bokoch GM and Rosen H: A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem Biol. 5:981–993. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Jaquet V, Marcoux J, Forest E, Leidal KG, McCormick S, Westermaier Y, Perozzo R, Plastre O, Fioraso-Cartier L, Diebold B, Scapozza L, Nauseef WM, Fieschi F, Krause KH and Bedard K: NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action. Br J Pharmacol. 164:507–520. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Verbon EH, Post JA and Boonstra J: The influence of reactive oxygen species on cell cycle progression in mammalian cells. Gene. 511:1–6. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Pelicano H, Feng L, Zhou Y, Carew JS, Hileman EO, Plunkett W, Keating MJ and Huang P: Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem. 278:37832–37839. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Guo C, Pan ZG, Li DJ, Yun JP, Zheng MZ, Hu ZY, Cheng LZ and Zeng YX: The expression of p63 is associated with the differential stage in nasopharyngeal carcinoma and EBV infection. J Transl Med. 4:232006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ding Y, Zhu W, Sun R, Yuan G, Zhang D, Fan Y and Sun J: Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells. Oncol Rep 33: 1434-1442, 2015.
APA
Ding, Y., Zhu, W., Sun, R., Yuan, G., Zhang, D., Fan, Y., & Sun, J. (2015). Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells. Oncology Reports, 33, 1434-1442. https://doi.org/10.3892/or.2015.3726
MLA
Ding, Y., Zhu, W., Sun, R., Yuan, G., Zhang, D., Fan, Y., Sun, J."Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells". Oncology Reports 33.3 (2015): 1434-1442.
Chicago
Ding, Y., Zhu, W., Sun, R., Yuan, G., Zhang, D., Fan, Y., Sun, J."Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells". Oncology Reports 33, no. 3 (2015): 1434-1442. https://doi.org/10.3892/or.2015.3726
Copy and paste a formatted citation
x
Spandidos Publications style
Ding Y, Zhu W, Sun R, Yuan G, Zhang D, Fan Y and Sun J: Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells. Oncol Rep 33: 1434-1442, 2015.
APA
Ding, Y., Zhu, W., Sun, R., Yuan, G., Zhang, D., Fan, Y., & Sun, J. (2015). Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells. Oncology Reports, 33, 1434-1442. https://doi.org/10.3892/or.2015.3726
MLA
Ding, Y., Zhu, W., Sun, R., Yuan, G., Zhang, D., Fan, Y., Sun, J."Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells". Oncology Reports 33.3 (2015): 1434-1442.
Chicago
Ding, Y., Zhu, W., Sun, R., Yuan, G., Zhang, D., Fan, Y., Sun, J."Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells". Oncology Reports 33, no. 3 (2015): 1434-1442. https://doi.org/10.3892/or.2015.3726
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