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Article

Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma

  • Authors:
    • Jin Wang
    • Jingjing Guan
    • Zhihua Lu
    • Jingji Jin
    • Yong Cai
    • Chunxi Wang
    • Fei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Bethune Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Epigenetics Laboratory, School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China
  • Pages: 1326-1334
    |
    Published online on: January 19, 2015
       https://doi.org/10.3892/or.2015.3733
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Abstract

Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and has been described as one of the deadliest of cancers affecting the genitourinary tract. Tropomyosin is a two-stranded α-helical coiled coil protein found in cell cytoskeletons. One of its isoforms, tropomyosin-1 (TPM1) has been reported as a novel tumor-suppressor gene and is downregulated in many solid tumors. However the expression level and function of TPM1 in RCC have not yet been determined. In the present study, we evaluated the TPM1-4 mRNA and TPM1 protein levels in RCC tissue samples. TPM1-overexpressing OSRC-2 and 786-O cell lines were also used to investigate the impact of TPM1 on RCC cells. We found that TPM1 was significantly and specifically downregulated in the RCC tissues. TPM1 expression was associated with tumor size, smoking status, Fuhrman grade and the prognosis of RCC patients. After TPM1 transfection, the migratory and invasive abilities of the OSRC-2 and 786-O cell lines were both reduced when compared to the control groups. Meanwhile, apoptosis was also enhanced in these two RCC cell lines following TPM1 transfection. Taken together, TPM1 exhibits characteristics of a tumor-suppressor gene while being overexpressed in RCC cell lines.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Guan J, Lu Z, Jin J, Cai Y, Wang C and Wang F: Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma. Oncol Rep 33: 1326-1334, 2015.
APA
Wang, J., Guan, J., Lu, Z., Jin, J., Cai, Y., Wang, C., & Wang, F. (2015). Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma. Oncology Reports, 33, 1326-1334. https://doi.org/10.3892/or.2015.3733
MLA
Wang, J., Guan, J., Lu, Z., Jin, J., Cai, Y., Wang, C., Wang, F."Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma". Oncology Reports 33.3 (2015): 1326-1334.
Chicago
Wang, J., Guan, J., Lu, Z., Jin, J., Cai, Y., Wang, C., Wang, F."Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma". Oncology Reports 33, no. 3 (2015): 1326-1334. https://doi.org/10.3892/or.2015.3733
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Guan J, Lu Z, Jin J, Cai Y, Wang C and Wang F: Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma. Oncol Rep 33: 1326-1334, 2015.
APA
Wang, J., Guan, J., Lu, Z., Jin, J., Cai, Y., Wang, C., & Wang, F. (2015). Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma. Oncology Reports, 33, 1326-1334. https://doi.org/10.3892/or.2015.3733
MLA
Wang, J., Guan, J., Lu, Z., Jin, J., Cai, Y., Wang, C., Wang, F."Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma". Oncology Reports 33.3 (2015): 1326-1334.
Chicago
Wang, J., Guan, J., Lu, Z., Jin, J., Cai, Y., Wang, C., Wang, F."Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma". Oncology Reports 33, no. 3 (2015): 1326-1334. https://doi.org/10.3892/or.2015.3733
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