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Molecular markers to assess short-term disease local recurrence in nasopharyngeal carcinoma

  • Authors:
    • Tao Xu
    • Bojin Su
    • Chunhua Wang
    • Sumei Wang
    • Hecheng Huang
    • Yunbao Pan
    • Donghui Wang
    • Weihong Wei
    • François X. Claret
    • Huiling Yang

  • View Affiliations

  • Published online on: January 20, 2015     https://doi.org/10.3892/or.2015.3739
  • Pages: 1418-1426
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Abstract

An important challenge in nasopharyngeal carcinoma (NPC) research is to develop effective predictors of tumor recurrence following treatment to determine whether immediate adjuvant therapy is necessary. We retrospectively analyzed archived specimens collected from 45 patients with paired samples of primary NPC (pNPC) and recurrent NPC (rNPC). Clinical samples were collected from the Cancer Center Databases of the First People's Hospital of Foshan and Shantou Central Hospital (affiliates of Sun Yat-Sen University) between 2001 and 2012. Expression levels of phosphor-Stat3 (p-Stat3), signalosome complex subunit 5 (Jab1/Csn5), Akt1, C/EBP homologous protein (CHOP), Ki-67, and apoptosis were determined by immunohistochemistry in pNPC and rNPC samples from the same patients. Differences in these markers between the short-term interval to recurrence (ITR) group (ITR <18 months) and long-term ITR group (ITR ≥18 months) were further analyzed. In Cox's regression analysis, the ITR was significantly associated as an independent‑negative prognostic factor for overall survival (hazard ratio, 0.211; 95% confidence interval, 0.053-0.841; P=0.027). p-Stat3 was increased in the short-term ITR group (ITR <18 months) and tended to be lower in the long-term ITR group (ITR ≥18 months). In the short-term ITR group, nuclear Akt expression was significantly increased in paired rNPC (P=0.028). In the long-term ITR group, the expression of nuclear Jab1/Csn5 (P=0.047) and assessment of apoptosis measured with TdT-mediated dUTP nick end‑labeling (TUNEL) (P=0.003) was significantly increased in paired rNPC. The results suggest that differences between short- and long-term ITR may predict outcome in rNPC. Furthermore, the overexpression of Jab1/Csn5 and Akt may contribute to the carcinogenesis of rNPC, and Akt seems to promote the progression of short-term ITR. Intra-individual changes of Jab1/Csn5, Akt, and TUNEL may help to identify short-term ITR.
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March-2015
Volume 33 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
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Spandidos Publications style
Xu T, Su B, Wang C, Wang S, Huang H, Pan Y, Wang D, Wei W, Claret FX, Yang H, Yang H, et al: Molecular markers to assess short-term disease local recurrence in nasopharyngeal carcinoma. Oncol Rep 33: 1418-1426, 2015
APA
Xu, T., Su, B., Wang, C., Wang, S., Huang, H., Pan, Y. ... Yang, H. (2015). Molecular markers to assess short-term disease local recurrence in nasopharyngeal carcinoma. Oncology Reports, 33, 1418-1426. https://doi.org/10.3892/or.2015.3739
MLA
Xu, T., Su, B., Wang, C., Wang, S., Huang, H., Pan, Y., Wang, D., Wei, W., Claret, F. X., Yang, H."Molecular markers to assess short-term disease local recurrence in nasopharyngeal carcinoma". Oncology Reports 33.3 (2015): 1418-1426.
Chicago
Xu, T., Su, B., Wang, C., Wang, S., Huang, H., Pan, Y., Wang, D., Wei, W., Claret, F. X., Yang, H."Molecular markers to assess short-term disease local recurrence in nasopharyngeal carcinoma". Oncology Reports 33, no. 3 (2015): 1418-1426. https://doi.org/10.3892/or.2015.3739