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Article

GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner

  • Authors:
    • Juan Ren
    • Hui Guo
    • Huili Wu
    • Tao Tian
    • Danfeng Dong
    • Yuelang Zhang
    • Yanxia Sui
    • Yong Zhang
    • Dongli Zhao
    • Shufeng Wang
    • Zongfang Li
    • Xiaozhi Zhang
    • Rui Liu
    • Jianshneg Qian
    • Hongxia Wei
    • Wenjun Jiang
    • Ya Liu
    • Yi Li
  • View Affiliations / Copyright

    Affiliations: Cancer Center, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Pathology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Orthopedics, Xi'an Children Hospital, Xi'an, Shaanxi 710061, P.R. China, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 1929-1937
    |
    Published online on: February 3, 2015
       https://doi.org/10.3892/or.2015.3779
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Abstract

Recent advances indicate that cancer‑associated fibroblasts (CAFs) play a key role in cancer progression by contributing to invasion, metastasis and angiogenesis. Solid tumors often experience low oxygen tension environments, which induce gene expression changes and biological features leading to poor outcomes. The G-protein estrogen receptor (GPER) exhibits a stimulatory role in diverse types of cancer cells and in CAFs under hypoxic conditions. We investigated the role of CAFs and hypoxia in breast cancer aggressiveness, and examined the effect of GPER in CAFs on hypoxia-driven breast cancer progression. The results showed that hypoxia upregulated HIF-1α, GPER and α-SMA expression in CAFs, and induced the secretion of Interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) in CAFs. However, GPER silencing abrogated the above hypoxia-driven cytokine expression in CAFs. Moreover, knockdown of GPER in CAFs suppressed breast cancer cell invasion induced by CAF conditioned media (CM). Furthermore, GPER silencing in CAFs inhibited hypoxia-increased CTGF expression in CAFs and breast cancer cells cultured with CM from CAFs under hypoxic conditions. In addition, CTGF is responsible for the observed effects of GPER on CAFs activation and breast cancer invasion. Our findings further extend the molecular mechanisms through which the tumor microenvironment may contribute to cancer progression.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Youlden DR, Cramb SM, Dunn NA, Muller JM, Pyke CM and Baade PD: The descriptive epidemiology of female breast cancer: an international comparison of screening, incidence, survival and mortality. Cancer Epidemiol. 36:237–248. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Clark CE, Hingorani SR, Mick R, Combs C, Tuveson DA and Vonderheide RH: Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res. 67:9518–9527. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Yen TW, Aardal NP, Bronner MP, Thorning DR, Savard CE, Lee SP and Bell RH Jr: Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas. Surgery. 131:129–134. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Hwang RF, Moore T, Arumugam T, Ramachandran V, Amos KD, Rivera A, Ji B, Evans DB and Logsdon CD: Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res. 68:918–926. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Neesse A, Michl P, Frese KK, et al: Stromal biology and therapy in pancreatic cancer. Gut. 60:861–868. 2011. View Article : Google Scholar

7 

Polyak K and Kalluri R: The role of the microenvironment in mammary gland development and cancer. Cold Spring Harb Perspect Biol. 2:a0032442010. View Article : Google Scholar : PubMed/NCBI

8 

Bhowmick NA, Neilson EG and Moses HL: Stromal fibroblasts in cancer initiation and progression. Nature. 432:332–337. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Kalluri R and Zeisberg M: Fibroblasts in cancer. Nat Rev Cancer. 6:392–401. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K and Sahai E: Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol. 9:1392–1400. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Shimoda M, Mellody KT and Orimo A: Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. Semin Cell Dev Biol. 21:19–25. 2010. View Article : Google Scholar :

12 

Liao D and Johnson RS: Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 26:281–290. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Harris AL: Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer. 2:38–47. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Rapisarda A and Melillo G: Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies. Drug Resist Updat. 12:74–80. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Lundgren K, Holm C and Landberg G: Hypoxia and breast cancer: prognostic and therapeutic implications. Cell Mol Life Sci. 64:3233–3247. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Michieli P: Hypoxia, angiogenesis and cancer therapy: to breathe or not to breathe. Cell Cycle. 8:3291–3296. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Lei J, Ma J, Ma Q, et al: Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner. Mol Cancer. 12:662013. View Article : Google Scholar : PubMed/NCBI

18 

Lei J, Huo X, Duan W, et al: α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion. Cancer Lett. 347:129–138. 2014. View Article : Google Scholar : PubMed/NCBI

19 

De Francesco EM, Lappano R, Santolla MF, Marsico S, Caruso A and Maggiolini M: HIF-1alpha/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs). Breast Cancer Res. 15:R642013. View Article : Google Scholar

20 

Madeo A and Maggiolini M: Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts. Cancer Res. 70:6036–6046. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Arias-Pulido H, Chaher N, Gong Y, Qualls C, Vargas J and Royce M: Tumor stromal vascular endothelial growth factor A is predictive of poor outcome in inflammatory breast cancer. BMC Cancer. 12:2982012. View Article : Google Scholar : PubMed/NCBI

23 

Staton CA, Reed MW and Brown NJ: A critical analysis of current in vitro and in vivo angiogenesis assays. Int J Exp Pathol. 90:195–221. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Comito G, Giannoni E, Di GP, Segura CP, Gerlini G and Chiarugi P: Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness. Cancer Lett. 324:31–41. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Yu T, Liu M, Luo H, Wu C, Tang X, Tang S, Hu P, Yan Y, Wang Z and Tu G: GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17β-estradiol in triple-negative breast cancer cells. J Steroid Biochem Mol Biol. 143:392–403. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Jiang QF, Wu TT, Yang JY, Dong CR, Wang N, Liu XH and Liu ZM: 17β-estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1. J Steroid Biochem Mol Biol. 138:314–324. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Dhar A and Ray A: The CCN family proteins in carcinogenesis. Exp Oncol. 32:2–9. 2010.PubMed/NCBI

28 

Chu CY, Chang CC, Prakash E and Kuo ML: Connective tissue growth factor (CTGF) and cancer progression. J Biomed Sci. 15:675–685. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Hall-Glenn F, De Young RA, Huang BL, et al: CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One. 7:e305622012. View Article : Google Scholar : PubMed/NCBI

30 

Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL and Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 121:335–348. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Ronnov-Jessen L and Petersen OW: Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab Invest. 68:696–707. 1993.PubMed/NCBI

32 

Ellis MJ, Singer C, Hornby A, Rasmussen A and Cullen KJ: Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer. Breast Cancer Res Treat. 31:249–261. 1994. View Article : Google Scholar : PubMed/NCBI

33 

Bronzert DA, Pantazis P, Antoniades HN, Kasid A, Davidson N, Dickson RB and Lippman ME: Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines. Proc Natl Acad Sci USA. 84:5763–5767. 1987. View Article : Google Scholar : PubMed/NCBI

34 

Taddei ML, Giannoni E, Raugei G, Scacco S, Sardanelli AM, Papa S and Chiarugi P: Mitochondrial oxidative stress due to complex I dysfunction promotes fibroblast activation and melanoma cell invasiveness. J Signal Transduct. 2012:6845922012. View Article : Google Scholar : PubMed/NCBI

35 

Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L and Chiarugi P: Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res. 70:6945–6956. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Cirri P and Chiarugi P: Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression. Cancer Metastasis Rev. 31:195–208. 2012. View Article : Google Scholar

37 

Giannoni E, Bianchini F, Calorini L and Chiarugi P: Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid Redox Signal. 14:2361–2371. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Mani SA, Guo W, Liao MJ, et al: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Giaccia AJ and Schipani E: Role of carcinoma-associated fibroblasts and hypoxia in tumor progression. Curr Top Microbiol Immunol. 345:31–45. 2010.PubMed/NCBI

40 

Melillo G: Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev. 26:341–352. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Recchia AG, De Francesco EM, Vivacqua A, Sisci D, Panno ML, Ando S and Maggiolini M: The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes. J Biol Chem. 286:10773–10782. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Lappano R, Recchia AG, De Francesco EM, Angelone T, Cerra MC, Picard D and Maggiolini M: The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor alpha-mediated signaling in cancer cells and in cardiomyocytes. PLoS One. 6:e166312011. View Article : Google Scholar

43 

Pandey DP, Lappano R, Albanito L, Madeo A, Maggiolini M and Picard D: Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. EMBO J. 28:523–532. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Semenza GL: Oxygen homeostasis. Wiley Interdiscip Rev Syst Biol Med. 2:336–361. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Youn SW, Lee SW, Lee J, et al: COMP-Ang1 stimulates HIF-1α-mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment. Blood. 117:4376–4386. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ren J, Guo H, Wu H, Tian T, Dong D, Zhang Y, Sui Y, Zhang Y, Zhao D, Wang S, Wang S, et al: GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner. Oncol Rep 33: 1929-1937, 2015.
APA
Ren, J., Guo, H., Wu, H., Tian, T., Dong, D., Zhang, Y. ... Li, Y. (2015). GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner. Oncology Reports, 33, 1929-1937. https://doi.org/10.3892/or.2015.3779
MLA
Ren, J., Guo, H., Wu, H., Tian, T., Dong, D., Zhang, Y., Sui, Y., Zhang, Y., Zhao, D., Wang, S., Li, Z., Zhang, X., Liu, R., Qian, J., Wei, H., Jiang, W., Liu, Y., Li, Y."GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner". Oncology Reports 33.4 (2015): 1929-1937.
Chicago
Ren, J., Guo, H., Wu, H., Tian, T., Dong, D., Zhang, Y., Sui, Y., Zhang, Y., Zhao, D., Wang, S., Li, Z., Zhang, X., Liu, R., Qian, J., Wei, H., Jiang, W., Liu, Y., Li, Y."GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner". Oncology Reports 33, no. 4 (2015): 1929-1937. https://doi.org/10.3892/or.2015.3779
Copy and paste a formatted citation
x
Spandidos Publications style
Ren J, Guo H, Wu H, Tian T, Dong D, Zhang Y, Sui Y, Zhang Y, Zhao D, Wang S, Wang S, et al: GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner. Oncol Rep 33: 1929-1937, 2015.
APA
Ren, J., Guo, H., Wu, H., Tian, T., Dong, D., Zhang, Y. ... Li, Y. (2015). GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner. Oncology Reports, 33, 1929-1937. https://doi.org/10.3892/or.2015.3779
MLA
Ren, J., Guo, H., Wu, H., Tian, T., Dong, D., Zhang, Y., Sui, Y., Zhang, Y., Zhao, D., Wang, S., Li, Z., Zhang, X., Liu, R., Qian, J., Wei, H., Jiang, W., Liu, Y., Li, Y."GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner". Oncology Reports 33.4 (2015): 1929-1937.
Chicago
Ren, J., Guo, H., Wu, H., Tian, T., Dong, D., Zhang, Y., Sui, Y., Zhang, Y., Zhao, D., Wang, S., Li, Z., Zhang, X., Liu, R., Qian, J., Wei, H., Jiang, W., Liu, Y., Li, Y."GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner". Oncology Reports 33, no. 4 (2015): 1929-1937. https://doi.org/10.3892/or.2015.3779
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