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Article

Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer

  • Authors:
    • Yu-Xiang Liang
    • Ru-Jun Mo
    • Hui-Chan He
    • Jia-Hong Chen
    • Jun Zou
    • Zhao-Dong Han
    • Jian-Ming Lu
    • Chao Cai
    • Yan-Ru Zeng
    • Wei-De Zhong
    • Chin-Lee Wu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China, Department of Urology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
  • Pages: 2648-2654
    |
    Published online on: March 20, 2015
       https://doi.org/10.3892/or.2015.3870
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Abstract

Our previous study revealed the potential role of CD147 in human prostate cancer (PCa). Here, we investigated the CD147 promoter methylation status and the correlation with tumorigenicity in human PCa. CD147 mRNA and protein expression levels were both significantly higher in the 4 PCa cell lines, than in the 2 non-tumorigenic benign human prostatic epithelial cell lines (all P<0.01). We showed hypomethylation of promoter regions of CD147 in PCa cell lines with significant CD147 expression as compared to non-tumorigenic benign human prostatic epithelial cell lines slowly expressing CD147. Additionally, the treatment of methylated cell lines with 5-aza-2'-deoxycytidine increased CD147 expression significantly in low-expressing cell lines and also activated the expression of matrix metalloproteinase (MMP)-2, which may be one of the most important downstream targets of CD147. Furthermore, PCa tissues displayed decreased DNA methylation in the promoter region of CD147 compared to the corresponding non‑cancerous prostate tissues, and methylation intensity correlated inversely with the CD147 mRNA levels. There was a significant negative correlation between CD147 mRNA levels and the number of methylated sites in PCa tissues (r=-0.467, P<0.01). In conclusion, our data offer convincing evidence for the first time that the DNA promoter hypomethylation of CD147 may be one of the regulatory mechanisms involved in the cancer-related overexpression of CD147 and may play a crucial role in the tumorigenesis of PCa.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Molitierno J, Evans A, Mohler JL, Wallen E, Moore D and Pruthi RS: Characterization of biochemical recurrence after radical prostatectomy. Urol Int. 77:130–134. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Klotz L: Hormone therapy for patients with prostate carcinoma. Cancer. 88(Suppl 12): 3009–3014. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Schoenborn JR, Nelson P and Fang M: Genomic profiling defines subtypes of prostate cancer with the potential for therapeutic stratification. Clin Cancer Res. 19:4058–4066. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Sharma S and Watabe K: Biomarkers and mechanisms associated with recurrent prostate cancer. Front Biosci (Landmark Ed). 19:339–351. 2014. View Article : Google Scholar

6 

Devaney JM, Wang S, Funda S, Long J, Taghipour DJ, Tbaishat R, Furbert-Harris P, Ittmann M and Kwabi-Addo B: Identification of novel DNA-methylated genes that correlate with human prostate cancer and high-grade prostatic intraepithelial neoplasia. Prostate Cancer Prostatic Dis. 16:292–300. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Yang B, Bhusari S, Kueck J, Weeratunga P, Wagner J, Leverson G, Huang W and Jarrard DF: Methylation profiling defines an extensive field defect in histologically normal prostate tissues associated with prostate cancer. Neoplasia. 15:399–408. 2013.PubMed/NCBI

8 

Lin PC, Giannopoulou EG, Park K, Mosquera JM, Sboner A, Tewari AK, Garraway LA, Beltran H, Rubin MA and Elemento O: Epigenomic alterations in localized and advanced prostate cancer. Neoplasia. 15:373–383. 2013.PubMed/NCBI

9 

Aryee MJ, Liu W, Engelmann JC, Nuhn P, Gurel M, Haffner MC, Esopi D, Irizarry RA, Getzenberg RH, Nelson WG, et al: DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Sci Transl Med. 5:169ra102013. View Article : Google Scholar : PubMed/NCBI

10 

Majumdar S, Buckles E, Estrada J and Koochekpour S: Aberrant DNA methylation and prostate cancer. Curr Genomics. 12:486–505. 2011. View Article : Google Scholar :

11 

Dimitriadis E, Kalogeropoulos T, Velaeti S, Sotiriou S, Vassiliou E, Fasoulis L, Klapsas V, Synesiou M, Apostolaki A, Trangas T, et al: Study of genetic and epigenetic alterations in urine samples as diagnostic markers for prostate cancer. Anticancer Res. 33:191–197. 2013.

12 

Yu YP, Ding Y, Chen R, Liao SG, Ren BG, Michalopoulos A, Michalopoulos G, Nelson J, Tseng GC and Luo JH: Whole-genome methylation sequencing reveals distinct impact of differential methylations on gene transcription in prostate cancer. Am J Pathol. 183:1960–1970. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Haldrup C, Mundbjerg K, Vestergaard EM, Lamy P, Wild P, Schulz WA, Arsov C, Visakorpi T, Borre M, Høyer S, et al: DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer. J Clin Oncol. 31:3250–3258. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Chao C, Chi M, Preciado M and Black MH: Methylation markers for prostate cancer prognosis: A systematic review. Cancer Causes Control. 24:1615–1641. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Dietrich D, Hasinger O, Bañez LL, Sun L, van Leenders GJ, Wheeler TM, Bangma CH, Wernert N, Perner S, Freedland SJ, et al: Development and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy. J Mol Diagn. 15:270–279. 2013. View Article : Google Scholar

16 

Kron K, Trudel D, Pethe V, Briollais L, Fleshner N, van der Kwast T and Bapat B: Altered DNA methylation landscapes of polycomb-repressed loci are associated with prostate cancer progression and ERG oncogene expression in prostate cancer. Clin Cancer Res. 19:3450–3461. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Vasiljević N, Ahmad AS, Beesley C, Thorat MA, Fisher G, Berney DM, Møller H, Yu Y, Lu YJ, Cuzick J, et al: Association between DNA methylation of HSPB1 and death in low Gleason score prostate cancer. Prostate Cancer Prostatic Dis. 16:35–40. 2013. View Article : Google Scholar

18 

Gabison EE, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA, De Wever B, Calvo F, Mauviel A and Menashi S: Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epitheliostromal interactions and matrix metalloproteinase induction. Am J Pathol. 166:209–219. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Sun J and Hemler ME: Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res. 61:2276–2281. 2001.PubMed/NCBI

20 

Wang L, Wu G, Yu L, Yuan J, Fang F, Zhai Z, Wang F and Wang H: Inhibition of CD147 expression reduces tumor cell invasion in human prostate cancer cell line via RNA interference. Cancer Biol Ther. 5:608–614. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Zhong WD, Han ZD, He HC, Bi XC, Dai QS, Zhu G, Ye YK, Liang YX, Qin WJ, Zhang Z, et al: CD147, MMP-1, MMP-2 and MMP-9 protein expression as significant prognostic factors in human prostate cancer. Oncology. 75:230–236. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Madigan MC, Kingsley EA, Cozzi PJ, Delprado WJ, Russell PJ and Li Y: The role of extracellular matrix metalloproteinase inducer protein in prostate cancer progression. Cancer Immunol Immunother. 57:1367–1379. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Hao JL, Cozzi PJ, Khatri A, Power CA and Li Y: CD147/EMMPRIN and CD44 are potential therapeutic targets for metastatic prostate cancer. Curr Cancer Drug Targets. 10:287–306. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Han ZD, Bi XC, Qin WJ, He HC, Dai QS, Zou J, Ye YK, Liang YX, Zeng GH, Chen ZN, et al: CD147 expression indicates unfavourable prognosis in prostate cancer. Pathol Oncol Res. 15:369–374. 2009. View Article : Google Scholar

25 

Zhong WD, Liang YX, Lin SX, Li L, He HC, Bi XC, Han ZD, Dai QS, Ye YK, Chen QB, et al: Expression of CD147 is associated with prostate cancer progression. Int J Cancer. 130:300–308. 2012. View Article : Google Scholar

26 

Liang L, Major T and Bocan T: Characterization of the promoter of human extracellular matrix metalloproteinase inducer (EMMPRIN). Gene. 282:75–86. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Truong M, Yang B, Livermore A, Wagner J, Weeratunga P, Huang W, Dhir R, Nelson J, Lin DW and Jarrard DF: Using the epigenetic field defect to detect prostate cancer in biopsy negative patients. J Urol. 189:2335–2341. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Liang Y, Mo R, He H, Chen J, Zou J, Han Z, Lu J, Cai C, Zeng Y, Zhong W, Zhong W, et al: Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer. Oncol Rep 33: 2648-2654, 2015.
APA
Liang, Y., Mo, R., He, H., Chen, J., Zou, J., Han, Z. ... Wu, C. (2015). Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer. Oncology Reports, 33, 2648-2654. https://doi.org/10.3892/or.2015.3870
MLA
Liang, Y., Mo, R., He, H., Chen, J., Zou, J., Han, Z., Lu, J., Cai, C., Zeng, Y., Zhong, W., Wu, C."Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer". Oncology Reports 33.5 (2015): 2648-2654.
Chicago
Liang, Y., Mo, R., He, H., Chen, J., Zou, J., Han, Z., Lu, J., Cai, C., Zeng, Y., Zhong, W., Wu, C."Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer". Oncology Reports 33, no. 5 (2015): 2648-2654. https://doi.org/10.3892/or.2015.3870
Copy and paste a formatted citation
x
Spandidos Publications style
Liang Y, Mo R, He H, Chen J, Zou J, Han Z, Lu J, Cai C, Zeng Y, Zhong W, Zhong W, et al: Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer. Oncol Rep 33: 2648-2654, 2015.
APA
Liang, Y., Mo, R., He, H., Chen, J., Zou, J., Han, Z. ... Wu, C. (2015). Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer. Oncology Reports, 33, 2648-2654. https://doi.org/10.3892/or.2015.3870
MLA
Liang, Y., Mo, R., He, H., Chen, J., Zou, J., Han, Z., Lu, J., Cai, C., Zeng, Y., Zhong, W., Wu, C."Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer". Oncology Reports 33.5 (2015): 2648-2654.
Chicago
Liang, Y., Mo, R., He, H., Chen, J., Zou, J., Han, Z., Lu, J., Cai, C., Zeng, Y., Zhong, W., Wu, C."Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer". Oncology Reports 33, no. 5 (2015): 2648-2654. https://doi.org/10.3892/or.2015.3870
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