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Article

Differential expression of serum microRNAs in cirrhosis that evolve into hepatocellular carcinoma related to hepatitis B virus

  • Authors:
    • Youwen Tan
    • Bin Lin
    • Yun Ye
    • Danfeng Wen
    • Li Chen
    • Xinbei Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Hepatosis, The Third Hospital of Zhenjiang Affiliated to Jiangsu University, Zhenjiang, Jiangsu, P.R. China, Department of Infectious Diseases, Jintan Hospital Affiliated to Jiangsu University, Changzhou, Jiangsu, P.R. China
  • Pages: 2863-2870
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    Published online on: April 24, 2015
       https://doi.org/10.3892/or.2015.3924
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Abstract

Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). Twenty-five patients with cirrhosis that evolved into HCC, who were treated at The Third Hospital of Zhenjiang Affiliated to Jiangsu University between January 2005 and December 2012, were enrolled. In the discovery stage, 2 serum samples pooled from 3 cirrhosis and 3 HCC samples were subjected to deep sequencing. Subsequently, differential expression of miRNAs was validated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in the serum samples from an independent cohort of 22 patients with cirrhosis and HCC. Twenty-two miRNAs showed a >2-fold upregulation (P<0.01), and 2 miRNAs showed a >2-fold downregulation (P<0.01) in the cirrhosis and HCC samples. Using the comparative Ct method, we calculated the 2-ΔΔCt for 40 candidate miRNAs in the sample sets. Eight of the 40 miRNAs demonstrated significantly differential expression levels between the disease categories. The miRNAs exhibiting differential expression were hsa-miR‑122-5p, hsa‑miR-199a-5p, hsa-miR‑486-5p, hsa‑miR‑193b-5p, hsa-miR‑206, hsa‑ miR‑141-3p, hsa‑miR‑192-5p and hsa‑miR‑26a-5p. We identified the miRNAs differentially expressed in cirrhosis that evolved into hepatitis B virus-related HCC.
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1 

Zemel R, Issachar A and Tur-Kaspa R: The role of oncogenic viruses in the pathogenesis of hepatocellular carcinoma. Clin Liver Dis. 15:261–279. vii–x. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Cui XW, Chang JM and Dietrich CF: Should hepatocellular carcinoma screening with ultrasound be recommended in hepatocellular carcinoma high-incidence areas? Hepatology. 61:1091–1092. 2015. View Article : Google Scholar

3 

Lo SS, Dawson LA, Kim EY, Mayr NA, Wang JZ, Huang Z and Cardenes HR: Stereotactic body radiation therapy for hepatocellular carcinoma. Discov Med. 9:404–410. 2010.PubMed/NCBI

4 

Petrelli A, Perra A, Cora D, Sulas P, Menegon S, Manca C, Migliore C, Kowalik MA, Ledda-Columbano GM, Giordano S, et al: MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC). Hepatology. 59:228–241. 2014. View Article : Google Scholar

5 

Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ and Lötvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 9:654–659. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Li Y and Kowdley KV: MicroRNAs in common human diseases. Genomics Proteomics Bioinformatics. 10:246–253. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Bala S, Petrasek J, Mundkur S, Catalano D, Levin I, Ward J, Alao H, Kodys K and Szabo G: Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology. 56:1946–1957. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Waidmann O, Bihrer V, Pleli T, Farnik H, Berger A, Zeuzem S, Kronenberger B and Piiper A: Serum microRNA-122 levels in different groups of patients with chronic hepatitis B virus infection. J Viral Hepat. 19:e58–e65. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Waidmann O, Köberle V, Brunner F, Zeuzem S, Piiper A and Kronenberger B: Serum microRNA-122 predicts survival in patients with liver cirrhosis. PLoS One. 7:e456522012. View Article : Google Scholar : PubMed/NCBI

10 

Wang J, Li J, Shen J, Wang C, Yang L and Zhang X: MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma. BMC Cancer. 12:2272012. View Article : Google Scholar : PubMed/NCBI

11 

Lamba V, Ghodke-Puranik Y, Guan W and Lamba JK: Identification of suitable reference genes for hepatic microRNA quantitation. BMC Res Notes. 7:1292014. View Article : Google Scholar : PubMed/NCBI

12 

Kutay H, Bai S, Datta J, Motiwala T, Pogribny I, Frankel W, Jacob ST and Ghoshal K: Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem. 99:671–678. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, Rebouissou S and Zucman-Rossi J: MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology. 47:1955–1963. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Li LM, Hu ZB, Zhou ZX, Chen X, Liu FY, Zhang JF, Shen HB, Zhang CY and Zen K: Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res. 70:9798–9807. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 133:647–658. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, Mazzaferro V, Lowe SW, Croce CM and Dejean A: miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci USA. 107:264–269. 2010. View Article : Google Scholar :

17 

Huang X and Jia Z: Construction of HCC-targeting artificial miRNAs using natural miRNA precursors. Exp Ther Med. 6:209–215. 2013.PubMed/NCBI

18 

Xu J, Wu C, Che X, Wang L, Yu D, Zhang T, Huang L, Li H, Tan W, Wang C, et al: Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. Mol Carcinog. 50:136–142. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Zhou J, Yu L, Gao X, Hu J, Wang J, Dai Z, Wang JF, Zhang Z, Lu S, Huang X, et al: Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol. 29:4781–4788. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Tan Y, Ge G, Pan T, Wen D, Chen L, Yu X, Zhou X and Gan J: A serum microRNA panel as potential biomarkers for hepatocellular carcinoma related with hepatitis B virus. PLoS One. 9:e1079862014. View Article : Google Scholar : PubMed/NCBI

21 

Tan Y, Ge G, Pan T, Wen D and Gan J: A pilot study of serum microRNAs panel as potential biomarkers for diagnosis of nonalcoholic fatty liver disease. PLoS One. 9:e1051922014. View Article : Google Scholar : PubMed/NCBI

22 

Peltier HJ and Latham GJ: Normalization of microRNA expression levels in quantitative RT-PCR assays: Identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA. 14:844–852. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Zhang H, Li QY, Guo ZZ, Guan Y, Du J, Lu YY, Hu YY, Liu P, Huang S and Su SB: Serum levels of microRNAs can specifically predict liver injury of chronic hepatitis B. World J Gastroenterol. 18:5188–5196. 2012.PubMed/NCBI

24 

Li G, Cai G, Li D and Yin W: MicroRNAs and liver disease: Viral hepatitis, liver fibrosis and hepatocellular carcinoma. Postgrad Med J. 90:106–112. 2014. View Article : Google Scholar

25 

Li ZJ, Ou-Yang PH and Han XP: Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells. Cell Signal. 26:141–148. 2014. View Article : Google Scholar

26 

Marin JJ, Bujanda L and Banales JM: MicroRNAs and cholestatic liver diseases. Curr Opin Gastroenterol. 30:303–309. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Papaconstantinou I, Karakatsanis A, Gazouli M, Polymeneas G and Voros D: The role of microRNAs in liver cancer. Eur J Gastroenterol Hepatol. 24:223–228. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Mei Q, Li X, Meng Y, Wu Z, Guo M, Zhao Y, Fu X and Han W: A facile and specific assay for quantifying microRNA by an optimized RT-qPCR approach. PLoS One. 7:e468902012. View Article : Google Scholar : PubMed/NCBI

29 

Salvi A, Abeni E, Portolani N, Barlati S and De Petro G: Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC. Int J Oncol. 42:391–402. 2013.

30 

Xu RH, Zheng LY, He DL, et al: Profiling of differentially expressed microRNAs (miRNAs) during differentiation of rat hepatic oval cells (HOCs) into hepatocellular carcinoma (HCC) cells. Clin Transl Oncol. 17:230–237. 2015. View Article : Google Scholar

31 

Li J, Wang Y, Yu W, Chen J and Luo J: Expression of serum miR-221 in human hepatocellular carcinoma and its prognostic significance. Biochem Biophys Res Commun. 406:70–73. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Tomimaru Y, Eguchi H, Nagano H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Tomokuni A, Takemasa I, Umeshita K, et al: Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. J Hepatol. 56:167–175. 2012. View Article : Google Scholar

33 

Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T and Shimotohno K: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 25:2537–2545. 2006. View Article : Google Scholar

34 

Jiang J, Gusev Y, Aderca I, Mettler TA, Nagorney DM, Brackett DJ, Roberts LR and Schmittgen TD: Association of microRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res. 14:419–427. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q, Qin L, Wu X, Zheng Y, Yang Y, et al: Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell. 19:232–243. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Morita K, Taketomi A, Shirabe K, Umeda K, Kayashima H, Ninomiya M, Uchiyama H, Soejima Y and Maehara Y: Clinical significance and potential of hepatic microRNA-122 expression in hepatitis C. Liver Int. 31:474–484. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Chang J, Nicolas E, Marks D, Sander C, Lerro A, Buendia MA, Xu C, Mason WS, Moloshok T, Bort R, et al: miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. RNA Biol. 1:106–113. 2004. View Article : Google Scholar

38 

Datta J, Kutay H, Nasser MW, Nuovo GJ, Wang B, Majumder S, Liu CG, Volinia S, Croce CM, Schmittgen TD, et al: Methylation mediated silencing of microRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res. 68:5049–5058. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Hsu SH, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, et al: Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest. 122:2871–2883. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Tsai WC, Hsu SD, Hsu CS, Lai TC, Chen SJ, Shen R, Huang Y, Chen HC, Lee CH, Tsai TF, et al: MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest. 122:2884–2897. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Kota J, Chivukula RR, O’Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, et al: Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell. 137:1005–1017. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, et al: MicroRNA expression, survival, and response to interferon in liver cancer. N Engl J Med. 361:1437–1447. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Qu KZ, Zhang K, Li H, Afdhal NH and Albitar M: Circulating microRNAs as biomarkers for hepatocellular carcinoma. J Clin Gastroenterol. 45:355–360. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tan Y, Lin B, Ye Y, Wen D, Chen L and Zhou X: Differential expression of serum microRNAs in cirrhosis that evolve into hepatocellular carcinoma related to hepatitis B virus. Oncol Rep 33: 2863-2870, 2015.
APA
Tan, Y., Lin, B., Ye, Y., Wen, D., Chen, L., & Zhou, X. (2015). Differential expression of serum microRNAs in cirrhosis that evolve into hepatocellular carcinoma related to hepatitis B virus. Oncology Reports, 33, 2863-2870. https://doi.org/10.3892/or.2015.3924
MLA
Tan, Y., Lin, B., Ye, Y., Wen, D., Chen, L., Zhou, X."Differential expression of serum microRNAs in cirrhosis that evolve into hepatocellular carcinoma related to hepatitis B virus". Oncology Reports 33.6 (2015): 2863-2870.
Chicago
Tan, Y., Lin, B., Ye, Y., Wen, D., Chen, L., Zhou, X."Differential expression of serum microRNAs in cirrhosis that evolve into hepatocellular carcinoma related to hepatitis B virus". Oncology Reports 33, no. 6 (2015): 2863-2870. https://doi.org/10.3892/or.2015.3924
Copy and paste a formatted citation
x
Spandidos Publications style
Tan Y, Lin B, Ye Y, Wen D, Chen L and Zhou X: Differential expression of serum microRNAs in cirrhosis that evolve into hepatocellular carcinoma related to hepatitis B virus. Oncol Rep 33: 2863-2870, 2015.
APA
Tan, Y., Lin, B., Ye, Y., Wen, D., Chen, L., & Zhou, X. (2015). Differential expression of serum microRNAs in cirrhosis that evolve into hepatocellular carcinoma related to hepatitis B virus. Oncology Reports, 33, 2863-2870. https://doi.org/10.3892/or.2015.3924
MLA
Tan, Y., Lin, B., Ye, Y., Wen, D., Chen, L., Zhou, X."Differential expression of serum microRNAs in cirrhosis that evolve into hepatocellular carcinoma related to hepatitis B virus". Oncology Reports 33.6 (2015): 2863-2870.
Chicago
Tan, Y., Lin, B., Ye, Y., Wen, D., Chen, L., Zhou, X."Differential expression of serum microRNAs in cirrhosis that evolve into hepatocellular carcinoma related to hepatitis B virus". Oncology Reports 33, no. 6 (2015): 2863-2870. https://doi.org/10.3892/or.2015.3924
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