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Article Open Access

HtrA1: Its future potential as a novel biomarker for cancer

  • Authors:
    • Emma Altobelli
    • Daniela Marzioni
    • Amedeo Lattanzi
    • Paolo Matteo Angeletti
  • View Affiliations / Copyright

    Affiliations: Department of Life, Health and Environmental Sciences, Epidemiology and Biostatistics Unit, AUSL Teramo, University of L'Aquila, L'Aquila, Italy, Department of Experimental and Clinical Medicine, University of Ancona, Ancona, Italy, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy
    Copyright: © Altobelli et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 555-566
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    Published online on: May 28, 2015
       https://doi.org/10.3892/or.2015.4016
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Abstract

HtrA1 appears to be involved in several physiological processes as well as in the pathogenesis of conditions such as Alzheimer's disease and osteoarthritis. It has also been hypothesized to play a role as a tumor suppressor. This manuscript reviews the current cancer-related HtrA1 research from the methodological and clinical standpoints including studies regarding its potential role as a tumor marker and/or prognostic factor. PRISMA method was used for study selection. The articles thus collected were examined and selected by two independent reviewers; any disagreement was resolved by a methodologist. A laboratory researcher reviewed the methods and laboratory techniques. Fifteen studies met the inclusion criteria and concerned the following cancer sites: the nervous system, bladder, breast, esophagus, stomach, liver, endometrium, thyroid, ovaries, pleura, lung and skin. Most articles described in vivo studies using a morphological approach and immunohistochemistry, whereas protein expression was quantified as staining intensity scored by two raters. Often the results were not comparable due to the different rating scales and study design. Current research on HtrA1 does not conclusively support its role as a tumor suppressor.
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Copy and paste a formatted citation
Spandidos Publications style
Altobelli E, Marzioni D, Lattanzi A and Angeletti PM: HtrA1: Its future potential as a novel biomarker for cancer. Oncol Rep 34: 555-566, 2015.
APA
Altobelli, E., Marzioni, D., Lattanzi, A., & Angeletti, P.M. (2015). HtrA1: Its future potential as a novel biomarker for cancer. Oncology Reports, 34, 555-566. https://doi.org/10.3892/or.2015.4016
MLA
Altobelli, E., Marzioni, D., Lattanzi, A., Angeletti, P. M."HtrA1: Its future potential as a novel biomarker for cancer". Oncology Reports 34.2 (2015): 555-566.
Chicago
Altobelli, E., Marzioni, D., Lattanzi, A., Angeletti, P. M."HtrA1: Its future potential as a novel biomarker for cancer". Oncology Reports 34, no. 2 (2015): 555-566. https://doi.org/10.3892/or.2015.4016
Copy and paste a formatted citation
x
Spandidos Publications style
Altobelli E, Marzioni D, Lattanzi A and Angeletti PM: HtrA1: Its future potential as a novel biomarker for cancer. Oncol Rep 34: 555-566, 2015.
APA
Altobelli, E., Marzioni, D., Lattanzi, A., & Angeletti, P.M. (2015). HtrA1: Its future potential as a novel biomarker for cancer. Oncology Reports, 34, 555-566. https://doi.org/10.3892/or.2015.4016
MLA
Altobelli, E., Marzioni, D., Lattanzi, A., Angeletti, P. M."HtrA1: Its future potential as a novel biomarker for cancer". Oncology Reports 34.2 (2015): 555-566.
Chicago
Altobelli, E., Marzioni, D., Lattanzi, A., Angeletti, P. M."HtrA1: Its future potential as a novel biomarker for cancer". Oncology Reports 34, no. 2 (2015): 555-566. https://doi.org/10.3892/or.2015.4016
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