Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
October-2015 Volume 34 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 34 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder

  • Authors:
    • Mariana Chantre-Justino
    • Gilda Alves
    • Constança Britto
    • Angélica Cardoso
    • Luciano Scherrer
    • Aline dos Santos Moreira
    • Raul Quirino
    • Antonio Ornellas
    • Alvaro Leitão
    • Claudia Lage
  • View Affiliations / Copyright

    Affiliations: Carlos Chagas Filho Institute of Biophysics, Rio de Janeiro Federal University, Rio de Janeiro, Brazil, Research Coordination, National Institute of Cancer (INCA), Rio de Janeiro, Brazil, Molecular Biology and Endemic Diseases Laboratory, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil, Brazilian Society of Clinical Oncology, Belo Horizonte, Minas Gerais, Brazil, DNA Sequencing Platform, PDTIS/FIOCRUZ, Rio de Janeiro, Brazil, Department of Urology, National Institute of Cancer, Rio de Janeiro, Brazil
    Copyright: © Chantre-Justino et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1667-1674
    |
    Published online on: July 24, 2015
       https://doi.org/10.3892/or.2015.4151
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Molecular evidence indicates that alterations in genes involved in the maintenance of genome stability may be related to susceptibility to bladder carcinoma. Our goal was to evaluate the prognostic role of base excision repair (BER) genes in a cohort of patients diagnosed with primary urothelial carcinoma of the bladder (UCB). The levels of all APE1, XRCC1 and POLB transcripts were detected by quantitative real-time PCR (qPCR) technique in tumor samples from 52 patients undergoing transurethral resection (TUR) for primary UCB at the Department of Urology, Brazilian National Cancer Institute, Rio de Janeiro. Increased levels of APE1, XRCC1 and POLB transcripts were significantly associated with high-grade tumors when compared to these levels in low-grade tumors (p<0.01) and could be attributed to different mechanisms of transcriptional regulation as a response to tumorigenesis and oxidative stress. By analyzing the collected data in the present study, regardless of pathological grade or stage, univariate analysis revealed that the reduced levels of APE1 transcripts were significantly associated with cancer-specific mortality (p=0.032). Furthermore, the variant genotype (TG/GG) of the APE1 T1349G polymorphism was observed in 75% of a subset of patients who concomitantly experienced reduced levels of the APE1 transcript and death and/or recurrence events. Taken together, our data reinforce the idea that human DNA repair mechanisms must be finely regulated in order to avoid instability leading to tumorigenesis and poor clinical outcomes in UCB patients.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Knowles MA: Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese? Carcinogenesis. 27:361–373. 2006. View Article : Google Scholar

3 

DeGraff DJ, Cates JM, Mauney JR, Clark PE, Matusik RJ and Adam RM: When urothelial differentiation pathways go wrong: Implications for bladder cancer development and progression. Urol Oncol. 31:802–811. 2013. View Article : Google Scholar

4 

Castillo-Martin M, Domingo-Domenech J, Karni-Schmidt O, Matos T and Cordon-Cardo C: Molecular pathways of urothelial development and bladder tumorigenesis. Urol Oncol. 28:401–408. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Burger M, Catto JW, Dalbagni G, Grossman HB, Herr H, Karakiewicz P, Kassouf W, Kiemeney LA, La Vecchia C, Shariat S, et al: Epidemiology and risk factors of urothelial bladder cancer. Eur Urol. 63:234–241. 2013. View Article : Google Scholar

6 

Kim WJ and Bae SC: Molecular biomarkers in urothelial bladder cancer. Cancer Sci. 99:646–652. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Shariat SF, Tokunaga H, Zhou J, Kim J, Ayala GE, Benedict WF and Lerner SP: p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. J Clin Oncol. 22:1014–1024. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Yang J, Xu Z, Li J, Zhang R, Zhang G, Ji H, Song B and Chen Z: XPC epigenetic silence coupled with p53 alteration has a significant impact on bladder cancer outcome. J Urol. 184:336–343. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Yan C, Kim YW, Ha YS, Kim IY, Kim YJ, Yun SJ, Moon SK, Bae SC and Kim WJ: RUNX3 methylation as a predictor for disease progression in patients with non-muscle-invasive bladder cancer. J Surg Oncol. 105:425–430. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Hoeijmakers JH: Genome maintenance mechanisms for preventing cancer. Nature. 411:366–374. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Christmann M, Tomicic MT, Roos WP and Kaina B: Mechanisms of human DNA repair: An update. Toxicology. 193:3–34. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Wood RD, Mitchell M and Lindahl T: Human DNA repair genes, 2005. Mutat Res. 577:275–283. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Zharkov DO: Base excision DNA repair. Cell Mol Life Sci. 65:1544–1565. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Figueroa JD, Malats N, Real FX, Silverman D, Kogevinas M, Chanock S, Welch R, Dosemeci M, Tardón A, Serra C, et al: Genetic variation in the base excision repair pathway and bladder cancer risk. Hum Genet. 121:233–242. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Fritz G: Human APE/Ref-1 protein. Int J Biochem Cell Biol. 32:925–929. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Kubota Y, Nash RA, Klungland A, Schär P, Barnes DE and Lindahl T: Reconstitution of DNA base excision-repair with purified human proteins: Interaction between DNA polymerase beta and the XRCC1 protein. EMBO J. 15:6662–6670. 1996.PubMed/NCBI

17 

Campalans A, Marsin S, Nakabeppu Y, O'connor TR, Boiteux S and Radicella JP: XRCC1 interactions with multiple DNA glycosylases: A model for its recruitment to base excision repair. DNA Repair (Amst). 4:826–835. 2005. View Article : Google Scholar

18 

Allinson SL, Dianova II and Dianov GL: DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts. EMBO J. 20:6919–6926. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Dyrskjøt L, Thykjaer T, Kruhøffer M, Jensen JL, Marcussen N, Hamilton-Dutoit S, Wolf H and Orntoft TF: Identifying distinct classes of bladder carcinoma using microarrays. Nat Genet. 33:90–96. 2003. View Article : Google Scholar

20 

Mengual L, Burset M, Ars E, Lozano JJ, Villavicencio H, Ribal MJ and Alcaraz A: DNA microarray expression profiling of bladder cancer allows identification of noninvasive diagnostic markers. J Urol. 182:741–748. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Damrauer JS, Hoadley KA, Chism DD, Fan C, Tiganelli CJ, Wobker SE, Yeh JJ, Milowsky MI, Iyer G, Parker JS, et al: Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology. Proc Natl Acad Sci USA. 111:3110–3115. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, et al: The MIQE guidelines: Minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 55:611–622. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Gecit I, Aslan M, Gunes M, Pirincci N, Esen R, Demir H and Ceylan K: Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer. J Cancer Res Clin Oncol. 138:739–743. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Kumar B, Koul S, Khandrika L, Meacham RB and Koul HK: Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res. 68:1777–1785. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A and Benhamou S: Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Carcinogenesis. 30:763–768. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Narter KF, Ergen A, Agaçhan B, Görmüs U, Timirci O and Isbir T: Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1). Anticancer Res. 29:1389–1393. 2009.PubMed/NCBI

27 

Zhuo W, Zhang L, Cai L, Zhu B and Chen Z: XRCC1 Arg399Gln polymorphism and bladder cancer risk: Updated meta-analyses based on 5767 cases and 6919 controls. Exp Biol Med (Maywood). 238:66–76. 2013. View Article : Google Scholar

28 

Weaver DA, Crawford EL, Warner KA, Elkhairi F, Khuder SA and Willey JC: ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines. Mol Cancer. 4:182005. View Article : Google Scholar : PubMed/NCBI

29 

Albertella MR, Lau A and O'Connor MJ: The overexpression of specialized DNA polymerases in cancer. DNA Repair (Amst). 4:583–593. 2005. View Article : Google Scholar

30 

Starcevic D, Dalal S and Sweasy JB: Is there a link between DNA polymerase beta and cancer? Cell Cycle. 3:998–1001. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Osheroff WP, Jung HK, Beard WA, Wilson SH and Kunkel TA: The fidelity of DNA polymerase beta during distributive and processive DNA synthesis. J Biol Chem. 274:3642–3650. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Bergoglio V, Pillaire MJ, Lacroix-Triki M, Raynaud-Messina B, Canitrot Y, Bieth A, Garès M, Wright M, Delsol G, Loeb LA, et al: Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Cancer Res. 62:3511–3514. 2002.PubMed/NCBI

33 

Bergoglio V, Ferrari E, Hübscher U, Cazaux C and Hoffmann JS: DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA. J Mol Biol. 331:1017–1023. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Pillaire MJ, Betous R, Conti C, Czaplicki J, Pasero P, Bensimon A, Cazaux C and Hoffmann JS: Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint. Cell Cycle. 6:471–477. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Berquist BR, McNeill DR and Wilson DM III: Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision. J Mol Biol. 379:17–27. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Bobola MS, Blank A, Berger MS, Stevens BA and Silber JR: Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas. Clin Cancer Res. 7:3510–3518. 2001.PubMed/NCBI

37 

Kelley MR, Cheng L, Foster R, Tritt R, Jiang J, Broshears J and Koch M: Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer. Clin Cancer Res. 7:824–830. 2001.PubMed/NCBI

38 

Moore DH, Michael H, Tritt R, Parsons SH and Kelley MR: Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers. Clin Cancer Res. 6:602–609. 2000.PubMed/NCBI

39 

Robertson KA, Bullock HA, Xu Y, Tritt R, Zimmerman E, Ulbright TM, Foster RS, Einhorn LH and Kelley MR: Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. Cancer Res. 61:2220–2225. 2001.PubMed/NCBI

40 

Zhang Y, Wang J, Xiang D, Wang D and Xin X: Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) in human ovarian cancer and indentification of the therapeutic potential of APE1/Ref-1 inhibitor. Int J Oncol. 35:1069–1079. 2009.PubMed/NCBI

41 

Sak SC, Harnden P, Johnston CF, Paul AB and Kiltie AE: APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer. Clin Cancer Res. 11:6205–6211. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Gu D, Wang M, Wang S, Zhang Z and Chen J: The DNA repair gene APE1 T1349G polymorphism and risk of gastric cancer in a Chinese population. PLoS One. 6:e289712011. View Article : Google Scholar : PubMed/NCBI

43 

Hadi MZ, Coleman MA, Fidelis K, Mohrenweiser HW and Wilson DM III: Functional characterization of Ape1 variants identified in the human population. Nucleic Acids Res. 28:3871–3879. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Au WW, Salama SA and Sierra-Torres CH: Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays. Environ Health Perspect. 111:1843–1850. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Gu D, Wang M, Wang M, Zhang Z and Chen J: The DNA repair gene APE1 T1349G polymorphism and cancer risk: A meta-analysis of 27 case-control studies. Mutagenesis. 24:507–512. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Liu C, Yin Q, Li L, Zhuang YZ, Zu X and Wang Y: APE1 Asp148Glu gene polymorphism and bladder cancer risk: A meta-analysis. Mol Biol Rep. 40:171–176. 2013. View Article : Google Scholar

47 

Sweasy JB, Lang T and DiMaio D: Is base excision repair a tumor suppressor mechanism? Cell Cycle. 5:250–259. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Kunath F, Krause SF, Wullich B, Goebell PJ, Engehausen DG, Burger M, Meerpohl JJ and Keck B: Bladder cancer - the neglected tumor: A descriptive analysis of publications referenced in MEDLINE and data from the register ClinicalTrials.gov. BMC Urol. 13:562013. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chantre-Justino M, Alves G, Britto C, Cardoso A, Scherrer L, dos Santos Moreira A, Quirino R, Ornellas A, Leitão A, Lage C, Lage C, et al: Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder. Oncol Rep 34: 1667-1674, 2015.
APA
Chantre-Justino, M., Alves, G., Britto, C., Cardoso, A., Scherrer, L., dos Santos Moreira, A. ... Lage, C. (2015). Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder. Oncology Reports, 34, 1667-1674. https://doi.org/10.3892/or.2015.4151
MLA
Chantre-Justino, M., Alves, G., Britto, C., Cardoso, A., Scherrer, L., dos Santos Moreira, A., Quirino, R., Ornellas, A., Leitão, A., Lage, C."Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder". Oncology Reports 34.4 (2015): 1667-1674.
Chicago
Chantre-Justino, M., Alves, G., Britto, C., Cardoso, A., Scherrer, L., dos Santos Moreira, A., Quirino, R., Ornellas, A., Leitão, A., Lage, C."Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder". Oncology Reports 34, no. 4 (2015): 1667-1674. https://doi.org/10.3892/or.2015.4151
Copy and paste a formatted citation
x
Spandidos Publications style
Chantre-Justino M, Alves G, Britto C, Cardoso A, Scherrer L, dos Santos Moreira A, Quirino R, Ornellas A, Leitão A, Lage C, Lage C, et al: Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder. Oncol Rep 34: 1667-1674, 2015.
APA
Chantre-Justino, M., Alves, G., Britto, C., Cardoso, A., Scherrer, L., dos Santos Moreira, A. ... Lage, C. (2015). Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder. Oncology Reports, 34, 1667-1674. https://doi.org/10.3892/or.2015.4151
MLA
Chantre-Justino, M., Alves, G., Britto, C., Cardoso, A., Scherrer, L., dos Santos Moreira, A., Quirino, R., Ornellas, A., Leitão, A., Lage, C."Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder". Oncology Reports 34.4 (2015): 1667-1674.
Chicago
Chantre-Justino, M., Alves, G., Britto, C., Cardoso, A., Scherrer, L., dos Santos Moreira, A., Quirino, R., Ornellas, A., Leitão, A., Lage, C."Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder". Oncology Reports 34, no. 4 (2015): 1667-1674. https://doi.org/10.3892/or.2015.4151
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team