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Article

MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma

Corrigendum in: /10.3892/or.2022.8358
  • Authors:
    • Ying Shan
    • Xingyu Li
    • Bo You
    • Si Shi
    • Qicheng Zhang
    • Yiwen You
  • View Affiliations / Copyright

    Affiliations: Department of Ear, Nose and Throat, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Pathology, Medical School of Nantong University, Nantong, Jiangsu 226001, P.R. China
  • Pages: 1943-1952
    |
    Published online on: August 10, 2015
       https://doi.org/10.3892/or.2015.4195
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Abstract

Nasopharyngeal cancer (NPC) is an endemic type of head and neck cancer with a high rate of cervical lymph node metastasis. An increasing number of studies have shown that microRNAs (miRNAs) play a key role in the development and progression of NPC. miR-338-3p has been demonstrated as an anti-oncogene in different solid tumors. The aim of the present study was to investigate the potential role of miR‑338-3p in the development and progression of NPC. Compared with normal samples, our data showed that miR-338-3p were downregulated in NPC tissues and cells. The luciferase assay demonstrated that HIF-1α was a direct target of miR-338-3p. We also found that miR-338-3p regulated the expression levels of HIF-1α, respectively. Overexpression of miR-338-3p in NPC cells significantly inhibited cell proliferation, and migration. Conversely, miR-338-3p knockdown in cells with lower endogenous expression levels significantly reduced antitumor behavior. Furthermore, enforced expression of miR-338-3p led to a decline in ERK phosphorylation as well as inhibited the hypoxia induced epithelial to mesenchymal transition. Cells pre-transfected with miR-338-3p can overcome hypoxia-mediated cisplatin resistance. Taken together, we found that miR-338-3p directly targeted HIF-1α, and we provide insight into NPC initiation and progression, possibly representing a novel therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Shan Y, Li X, You B, Shi S, Zhang Q and You Y: MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma Corrigendum in /10.3892/or.2022.8358. Oncol Rep 34: 1943-1952, 2015.
APA
Shan, Y., Li, X., You, B., Shi, S., Zhang, Q., & You, Y. (2015). MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma Corrigendum in /10.3892/or.2022.8358. Oncology Reports, 34, 1943-1952. https://doi.org/10.3892/or.2015.4195
MLA
Shan, Y., Li, X., You, B., Shi, S., Zhang, Q., You, Y."MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma Corrigendum in /10.3892/or.2022.8358". Oncology Reports 34.4 (2015): 1943-1952.
Chicago
Shan, Y., Li, X., You, B., Shi, S., Zhang, Q., You, Y."MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma Corrigendum in /10.3892/or.2022.8358". Oncology Reports 34, no. 4 (2015): 1943-1952. https://doi.org/10.3892/or.2015.4195
Copy and paste a formatted citation
x
Spandidos Publications style
Shan Y, Li X, You B, Shi S, Zhang Q and You Y: MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma Corrigendum in /10.3892/or.2022.8358. Oncol Rep 34: 1943-1952, 2015.
APA
Shan, Y., Li, X., You, B., Shi, S., Zhang, Q., & You, Y. (2015). MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma Corrigendum in /10.3892/or.2022.8358. Oncology Reports, 34, 1943-1952. https://doi.org/10.3892/or.2015.4195
MLA
Shan, Y., Li, X., You, B., Shi, S., Zhang, Q., You, Y."MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma Corrigendum in /10.3892/or.2022.8358". Oncology Reports 34.4 (2015): 1943-1952.
Chicago
Shan, Y., Li, X., You, B., Shi, S., Zhang, Q., You, Y."MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma Corrigendum in /10.3892/or.2022.8358". Oncology Reports 34, no. 4 (2015): 1943-1952. https://doi.org/10.3892/or.2015.4195
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