Regulation mechanism of Fbxw7-related signaling pathways (Review)

  • Authors:
    • Zhenyu Zhou
    • Chuanchao He
    • Jie Wang
  • View Affiliations

  • Published online on: August 26, 2015     https://doi.org/10.3892/or.2015.4227
  • Pages: 2215-2224
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

F-box and WD repeat domain-containing 7 (Fbxw7), the substrate-recognition component of SCFFbxw7 complex, is thought to be a tumor suppressor involved in cell growth, proliferation, differentiation and survival. Although an increasing number of ubiquitin substrates of Fbxw7 have been identified, the best characterized substrates are cyclin E and c-Myc. Fbxw7/cyclin E and Fbxw7/c-Myc pathways are tightly regulated by multiple regulators. Fbxw7 has been identified as a tumor suppressor in hepatocellular carcinoma. This review focused on the regulation of Fbxw7/cyclin E and Fbxw7/c-Myc pathways and discussed findings to gain a better understanding of the role of Fbxw7 in hepatocellular carcinoma.
View Figures
View References

Related Articles

Journal Cover

November-2015
Volume 34 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Z, He C and Wang J: Regulation mechanism of Fbxw7-related signaling pathways (Review). Oncol Rep 34: 2215-2224, 2015
APA
Zhou, Z., He, C., & Wang, J. (2015). Regulation mechanism of Fbxw7-related signaling pathways (Review). Oncology Reports, 34, 2215-2224. https://doi.org/10.3892/or.2015.4227
MLA
Zhou, Z., He, C., Wang, J."Regulation mechanism of Fbxw7-related signaling pathways (Review)". Oncology Reports 34.5 (2015): 2215-2224.
Chicago
Zhou, Z., He, C., Wang, J."Regulation mechanism of Fbxw7-related signaling pathways (Review)". Oncology Reports 34, no. 5 (2015): 2215-2224. https://doi.org/10.3892/or.2015.4227