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Article

Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells

  • Authors:
    • Tangxin Gao
    • Shangyong Zheng
    • Qian Li
    • Pengzhan Ran
    • Lijuan Sun
    • Yuncang Yuan
    • Chunjie Xiao
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Yunnan University, Kunming, Yunnan 650091, P.R. China, Key Laboratory of Molecular Genetics of Human Complicated Diseases, Department of Education, Kunming, Yunnan 650091, P.R. China
  • Pages: 2333-2342
    |
    Published online on: September 2, 2015
       https://doi.org/10.3892/or.2015.4245
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Abstract

The eyes absent homologue 2 (EYA2) is a dual-functional transcription factor/phosphatase that plays a critical role in neoplasia. The precise effects of EYA2 remain elusive in non-small cell lung cancer (NSCLC). In the present study, we examined EYA2 expression in NSCLC cell lines and a normal pulmonary epithelial cell line. We found that EYA2 was aberrantly upregulated in the lung adenocarcinoma cells. Therefore, we studied the methylation status of the eya2 gene in a lung adenocarcinoma cell line, a normal pulmonary epithelial cell line and lung adenocarcinoma tissues. Furthermore, the eya2 gene was knocked down in lung adenocarcinoma cells via RNA interference to investigate the regulatory role of EYA2; specifically, cell proliferation, cell cycle distribution, apoptosis, migration and invasive capacities were assessed in tje EYA2‑knockdown cancer cells. The results showed that the aberrant hypomethylation and overexpression of the eya2 gene were associated with lung adenocarcinoma oncogenesis. In addition, inhibition of EYA2 expression suppressed tumour cell growth by altering the proliferation, cell cycle distribution, apoptosis, migration and invasive capacities of the cells. These findings demonstrated that EYA2 functions as a stimulant in lung adenocarcinoma pathogenesis and may facilitate the development of novel diagnostic targets and therapy strategies for lung adenocarcinoma.
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1 

Kumar V; Abass KA, Fausto N and Mitchell R: Robbins Basic Pathology. 8th edition. Saunders Elsevier; Philadelphia, PA: 2007

2 

Brambilla E, Travis WD, Colby TV, Corrin B and Shimosato Y: The new World Health Organization classification of lung tumours. Eur Respir J. 18:1059–1068. 2001. View Article : Google Scholar

3 

Chu XY, Hou XB, Song WA, Xue ZQ, Wang B and Zhang LB: Diagnostic values of SCC, CEA, Cyfra21-1 and NSE for lung cancer in patients with suspicious pulmonary masses: A single center analysis. Cancer Biol Ther. 11:995–1000. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Portela A and Esteller M: Epigenetic modifications and human disease. Nat Biotechnol. 28:1057–1068. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Takai D and Jones PA: Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci USA. 99:3740–3745. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Grønbaek K, Hother C and Jones PA: Epigenetic changes in cancer. APMIS. 115:1039–1059. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Lokk K, Vooder T, Kolde R, Välk K, Võsa U, Roosipuu R, Milani L, Fischer K, Koltsina M, Urgard E, et al: Methylation markers of early-stage non-small cell lung cancer. PLoS One. 7:e398132012. View Article : Google Scholar : PubMed/NCBI

8 

Tekpli X, Landvik NE, Anmarkud KH, Skaug V, Haugen A and Zienolddiny S: DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer. Cancer Immunol Immunother. 62:337–345. 2013. View Article : Google Scholar

9 

Sato T, Arai E, Kohno T, Tsuta K, Watanabe S, Soejima K, Betsuyaku T and Kanai Y: DNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma. PLoS One. 8:e594442013. View Article : Google Scholar : PubMed/NCBI

10 

Pesta M, Kulda V, Topolcan O, Safranek J, Vrzalova J, Cerny R and Holubec L: Significance of methylation status and the expression of RECK mRNA in lung tissue of patients with NSCLC. Anticancer Res. 29:4535–4539. 2009.PubMed/NCBI

11 

Suzuki M, Shiraishi K, Eguchi A, Ikeda K, Mori T, Yoshimoto K, Ohba Y, Yamada T, Ito T, Baba Y, et al: Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer. Oncol Rep. 29:1308–1314. 2013.PubMed/NCBI

12 

Grimminger PP, Maus MK, Schneider PM, Metzger R, Hölscher AH, Sugita H, Danenberg PV, Alakus H and Brabender J: Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC. Lung Cancer. 78:87–91. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Duan H, He Z, Ma J, Zhang B, Sheng Z, Bin P, Cheng J, Niu Y, Dong H, Lin H, et al: Global and MGMT promoter hypomethylation independently associated with genomic instability of lymphocytes in subjects exposed to high-dose polycyclic aromatic hydrocarbon. Arch Toxicol. 87:2013–2022. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Tadjuidje E and Hegde RS: The eyes absent proteins in development and disease. Cell Mol Life Sci. 70:1897–1913. 2013. View Article : Google Scholar :

15 

Huang YT, Heist RS, Chirieac LR, Lin X, Skaug V, Zienolddiny S, Haugen A, Wu MC, Wang Z, Su L, et al: Genome-wide analysis of survival in early-stage non-small-cell lung cancer. J Clin Oncol. 27:2660–2667. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Bierkens M, Krijgsman O, Wilting SM, Bosch L, Jaspers A, Meijer GA, Meijer CJ, Snijders PJ, Ylstra B and Steenbergen RD: Focal aberrations indicate EYA2 and hsa-miR-375 as oncogene and tumor suppressor in cervical carcinogenesis. Genes Chromosomes Cancer. 52:56–68. 2013. View Article : Google Scholar

17 

Farabaugh SM, Micalizzi DS, Jedlicka P, Zhao R and Ford HL: Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties. Oncogene. 31:552–562. 2012.

18 

Zhang L, Yang N, Huang J, Buckanovich RJ, Liang S, Barchetti A, Vezzani C, O'Brien-Jenkins A, Wang J, Ward MR, et al: Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth. Cancer Res. 65:925–932. 2005.PubMed/NCBI

19 

Yeh PA, Yang WH, Chiang PY, Wang SC, Chang MS and Chang CJ: Drosophila eyes absent is a novel mRNA target of the tristetraprolin (TTP) protein DTIS11. Int J Biol Sci. 8:606–619. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zou H, Harrington JJ, Shire AM, Rego RL, Wang L, Campbell ME, Oberg AL and Ahlquist DA: Highly methylated genes in colorectal neoplasia: implications for screening. Cancer Epidemiol, Biomarkers Prev. 16:2686–2696. 2007. View Article : Google Scholar

21 

Vincent A, Hong SM, Hu C, Omura N, Young A, Kim H, Yu J, Knight S, Ayars M, Griffith M, et al: Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth. Oncotarget. 5:2575–2587. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Jemc J and Rebay I: Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Dev Biol. 310:416–429. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Jemc J and Rebay I: The eyes absent family of phosphotyrosine phosphatases: Properties and roles in developmental regulation of transcription. Annu Rev Biochem. 76:513–538. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Krishnan N, Jeong DG, Jung SK, Ryu SE, Xiao A, Allis CD, Kim SJ and Tonks NK: Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem. 284:16066–16070. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Spackman E and Suarez DL: Type A influenza virus detection and quantitation by real-time RT-PCR. Methods Mol Biol. 436:19–26. 2008.PubMed/NCBI

26 

Kobayashi H and Kono T: DNA methylation analysis of germ cells by using bisulfite-based sequencing methods. Methods Mol Biol. 825:223–235. 2012. View Article : Google Scholar

27 

Becker D, Lutsik P, Ebert P, Bock C, Lengauer T and Walter J: BiQ Analyzer HiMod: An interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives. Nucleic Acids Res. 42(W1): W501–W507. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Arranz-Valsero I, Soriano-Romaní L, García-Posadas L, López-García A and Diebold Y: IL-6 as a corneal wound healing mediator in an in vitro scratch assay. Exp Eye Res. 125:183–192. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Guo J, Lin P, Zhao X, Zhang J, Wei X, Wang Q and Wang C: Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuro-inflammatory response and depressive-like behavior in mice. Neuroscience. 263:1–14. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Yang DK, Choi BY, Lee YH, Kim YG, Cho MC, Hong SE, Kim H, Hajjar RJ and Park WJ: Gene profiling during regression of pressure overload-induced cardiac hypertrophy. Physiol Genomics. 30:1–7. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Lee SH, Yang DK, Choi BY, Lee YH, Kim SY, Jeong D, Hajjar RJ and Park WJ: The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling. J Mol Cell Cardiol. 46:596–605. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Lee SH, Kim J, Ryu JY, Lee S, Yang DK, Jeong D, Kim J, Lee SH, Kim JM, Hajjar RJ, et al: Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. J Mol Cell Cardiol. 52:718–726. 2012. View Article : Google Scholar

33 

Patrick AN, Cabrera JH, Smith AL, Chen XS, Ford HL and Zhao R: Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. Nat Struct Mol Biol. 20:447–453. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S and Kawakami K: Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol. 19:6815–6824. 1999.PubMed/NCBI

35 

Grifone R, Demignon J, Giordani J, Niro C, Souil E, Bertin F, Laclef C, Xu PX and Maire P: Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 302:602–616. 2007. View Article : Google Scholar

36 

Embry AC, Glick JL, Linder ME and Casey PJ: Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. Mol Pharmacol. 66:1325–1331. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Ali-Khan SE and Hales BF: Novel retinoid targets in the mouse limb during organogenesis. Toxicol Sci. 94:139–152. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Molinari M: Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif. 33:261–274. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Fu J, Xu X, Kang L, Zhou L, Wang S, Lu J, Cheng L, Fan Z, Yuan B, Tian P, et al: miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2. Biochem Biophys Res Commun. 445:314–319. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Clark SW, Fee BE and Cleveland JL: Misexpression of the eyes absent family triggers the apoptotic program. J Biol Chem. 277:3560–3567. 2002. View Article : Google Scholar

41 

Matt N, Dupé V, Garnier JM, Dennefeld C, Chambon P, Mark M and Ghyselinck NB: Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development. 132:4789–4800. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, et al: Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 426:247–254. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Kohrt D, Crary J, Zimmer M, Patrick AN, Ford HL, Hinds PW and Grossel MJ: CDK6 binds and promotes the degradation of the EYA2 protein. Cell Cycle. 13:62–71. 2014. View Article : Google Scholar :

44 

Bonini NM, Leiserson WM and Benzer S: The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye. Cell. 72:379–395. 1993. View Article : Google Scholar : PubMed/NCBI

45 

Pandey RN, Rani R, Yeo EJ, Spencer M, Hu S, Lang RA and Hegde RS: The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene. 29:3715–3722. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, et al: Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. J Biol Chem. 289:16349–16361. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gao T, Zheng S, Li Q, Ran P, Sun L, Yuan Y and Xiao C: Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells. Oncol Rep 34: 2333-2342, 2015.
APA
Gao, T., Zheng, S., Li, Q., Ran, P., Sun, L., Yuan, Y., & Xiao, C. (2015). Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells. Oncology Reports, 34, 2333-2342. https://doi.org/10.3892/or.2015.4245
MLA
Gao, T., Zheng, S., Li, Q., Ran, P., Sun, L., Yuan, Y., Xiao, C."Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells". Oncology Reports 34.5 (2015): 2333-2342.
Chicago
Gao, T., Zheng, S., Li, Q., Ran, P., Sun, L., Yuan, Y., Xiao, C."Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells". Oncology Reports 34, no. 5 (2015): 2333-2342. https://doi.org/10.3892/or.2015.4245
Copy and paste a formatted citation
x
Spandidos Publications style
Gao T, Zheng S, Li Q, Ran P, Sun L, Yuan Y and Xiao C: Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells. Oncol Rep 34: 2333-2342, 2015.
APA
Gao, T., Zheng, S., Li, Q., Ran, P., Sun, L., Yuan, Y., & Xiao, C. (2015). Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells. Oncology Reports, 34, 2333-2342. https://doi.org/10.3892/or.2015.4245
MLA
Gao, T., Zheng, S., Li, Q., Ran, P., Sun, L., Yuan, Y., Xiao, C."Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells". Oncology Reports 34.5 (2015): 2333-2342.
Chicago
Gao, T., Zheng, S., Li, Q., Ran, P., Sun, L., Yuan, Y., Xiao, C."Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells". Oncology Reports 34, no. 5 (2015): 2333-2342. https://doi.org/10.3892/or.2015.4245
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