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Article

Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype

  • Authors:
    • Xiu Long Niu
    • Yue Wang
    • Zhi Yao
    • Hongjie Duan
    • Zhijun Li
    • Wenxing Liu
    • Hongjian Zhang
    • Wei Min Deng
  • View Affiliations / Copyright

    Affiliations: Department of Immunology of Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Diseases and Microenvironment of Ministry of Education of China, Heping, Tianjin, P.R. China, Department of Immunology, Logistics College of Chinese People's Armed Police Forces, Heping, Tianjin, P.R. China
  • Pages: 3120-3130
    |
    Published online on: September 18, 2015
       https://doi.org/10.3892/or.2015.4294
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Abstract

Mitogenic actions of estrogens are mediated by two distinct estrogen receptors (ERs), which are critical in the progression and therapeutic response of breast cancer. ER expression is a dynamic phenomenon that is regulated by numerous factors, including cytokines, in the tumor microenvironment. Recently, studies have shown that autocrine production of IL-4 promotes cancer cell growth and there is negative correlation between tumor IL-4 and hormone receptor levels, suggesting that there is crosstalk between cytokine receptors and ER. Thus, we evaluated for interaction between the two ERs and the cytokines IL-4 and IFN-γ, and if this interaction modulates malignant behavior. We identified that ERβ exerts protective activity in the progression of breast cancer cell line MCF-7, which co-expresses ERα and ERβ. IFN-γ and IL-4 have the opposite effects on malignant biological behavior. Furthermore, we found positive correlation between IFN-γ and ERβ expression in MCF-7. We also determined that autocrine IFN-γ in MCF-7 increases mRNA expression of ERβ resulting in enhanced sensitivity to tamoxifen (TAM). These results indicate that ERβ and autocrine IFN-γ represent two putative targets for breast cancer therapy.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Ziegler RG, Anderson WF and Gail MH: Increasing breast cancer incidence in China: The numbers add up. J Natl Cancer Inst. 100:1339–1341. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Yue W, Yager JD, Wang JP, Jupe ER and Santen RJ: Estrogen receptor-dependent and independent mechanisms of breast cancer carcinogenesis. Steroids. 78:161–170. 2013. View Article : Google Scholar

4 

Mosselman S, Polman J and Dijkema R: ER beta: Identification and characterization of a novel human estrogen receptor. FEBS Lett. 392:49–53. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Williams C and Lin CY: Oestrogen receptors in breast cancer: Basic mechanisms and clinical implications. E Cancer Med Sci. 7:3702013.

6 

Skliris GP, Munot K, Bell SM, Carder PJ, Lane S, Horgan K, Lansdown MR, Parkes AT, Hanby AM, Markham AF, et al: Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model. J Pathol. 201:213–220. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Han SJ, Guo QQ, Wang T, Wang YX, Zhang YX, Liu F, Luo YX, Zhang J, Wang YL, Yan YX, et al: Prognostic significance of interactions between ER alpha and ER beta and lymph node status in breast cancer cases. Asian Pac J Cancer Prev. 14:6081–6084. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Platet N, Cathiard AM, Gleizes M and Garcia M: Estrogens and their receptors in breast cancer progression: A dual role in cancer proliferation and invasion. Crit Rev Oncol Hematol. 51:55–67. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Pettersson K, Delaunay F and Gustafsson JA: Estrogen receptor beta acts as a dominant regulator of estrogen signaling. Oncogene. 19:4970–4978. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Nilsson S, Mäkelä S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M and Gustafsson JA: Mechanisms of estrogen action. Physiol Rev. 81:1535–1565. 2001.PubMed/NCBI

11 

Fuqua SA, Schiff R, Parra I, Moore JT, Mohsin SK, Osborne CK, Clark GM and Allred DC: Estrogen receptor beta protein in human breast cancer: Correlation with clinical tumor parameters. Cancer Res. 63:2434–2439. 2003.PubMed/NCBI

12 

O'Neill PA, Davies MP, Shaaban AM, Innes H, Torevell A, Sibson DR and Foster CS: Wild-type oestrogen receptor beta (ERbeta1) mRNA and protein expression in Tamoxifen-treated post-menopausal breast cancers. Br J Cancer. 91:1694–1702. 2004.PubMed/NCBI

13 

Kerdivel G, Flouriot G and Pakdel F: Modulation of estrogen receptor alpha activity and expression during breast cancer progression. Vitam Horm. 93:135–160. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Stassi G, Todaro M, Zerilli M, Ricci-Vitiani L, Di Liberto D, Patti M, Florena A, Di Gaudio F, Di Gesù G and De Maria R: Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10. Cancer Res. 63:6784–6790. 2003.PubMed/NCBI

15 

Mahmoud SM, Paish EC, Powe DG, Macmillan RD, Grainge MJ, Lee AH, Ellis IO and Green AR: Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. J Clin Oncol. 29:1949–1955. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Nagai S and Toi M: Interleukin-4 and breast cancer. Breast Cancer. 7:181–186. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Kmieciak M, Payne KK, Idowu MO, Grimes MM, Graham L, Ascierto ML, Wang E, Wang XY, Bear HD and Manjili MH: Tumor escape and progression of HER-2/neu negative breast cancer under immune pressure. J Transl Med. 9:352011. View Article : Google Scholar : PubMed/NCBI

18 

Chen C, Guo L, Shi M, Hu M, Hu M, Yu M, Wang T, Song L, Shen B, Qian L, et al: Modulation of IFN-γ receptor 1 expression by AP-2α influences IFN-γ sensitivity of cancer cells. Am J Pathol. 180:661–671. 2012. View Article : Google Scholar

19 

García-Tuñón I, Ricote M, Ruiz AA, Fraile B, Paniagua R and Royuela M: Influence of IFN-gamma and its receptors in human breast cancer. BMC Cancer. 7:1582007. View Article : Google Scholar : PubMed/NCBI

20 

Obiri NI, Siegel JP, Varricchio F and Puri RK: Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells. Clin Exp Immunol. 95:148–155. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Obiri NI, Hillman GG, Haas GP, Sud S and Puri RK: Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4. J Clin Invest. 91:88–93. 1993. View Article : Google Scholar : PubMed/NCBI

22 

Varricchio F, Obiri NI, Haas GP and Puri RK: Immunostaining of interleukin-4 receptor on human renal cell carcinoma. Lymphokine Cytokine Res. 12:465–469. 1993.PubMed/NCBI

23 

Toi M, Bicknell R and Harris AL: Inhibition of colon and breast carcinoma cell growth by interleukin-4. Cancer Res. 52:275–279. 1992.PubMed/NCBI

24 

Todaro M, Lombardo Y, Francipane MG, Alea MP, Cammareri P, Iovino F, Di Stefano AB, Di Bernardo C, Agrusa A, Condorelli G, et al: Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4. Cell Death Differ. 15:762–772. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Prokopchuk O, Liu Y, Henne-Bruns D and Kornmann M: Interleukin-4 enhances proliferation of human pancreatic cancer cells: Evidence for autocrine and paracrine actions. Br J Cancer. 92:921–928. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Conticello C, Pedini F, Zeuner A, Patti M, Zerilli M, Stassi G, Messina A, Peschle C and De Maria R: IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins. J Immunol. 172:5467–5477. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Todaro M, Zerilli M, Ricci-Vitiani L, Bini M, Perez Alea M, Maria Florena A, Miceli L, Condorelli G, Bonventre S, Di Gesù G, et al: Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells. Cancer Res. 66:1491–1499. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Turgeon C, Gingras S, Carrière MC, Blais Y, Labrie F and Simard J: Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells. J Steroid Biochem Mol Biol. 65:151–162. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Hong CC, Yao S, McCann SE, Dolnick RY, Wallace PK, Gong Z, Quan L, Lee KP, Evans SS, Repasky EA, et al: Pretreatment levels of circulating Th1 and Th2 cytokines, and their ratios, are associated with ER-negative and triple negative breast cancers. Breast Cancer Res Treat. 139:477–488. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Li HZ, Wang Y, Gao Y, Shao J, Zhao XL, Deng WM, Liu YX, Yang J and Yao Z: Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer. Mol Cancer Res. 6:917–928. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Huang B, Omoto Y, Iwase H, Yamashita H, Toyama T, Coombes RC, Filipovic A, Warner M and Gustafsson JÅ: Differential expression of estrogen receptor α, β1, and β2 in lobular and ductal breast cancer. Proc Natl Acad Sci USA. 111:1933–1938. 2014. View Article : Google Scholar

32 

Murphy LC and Leygue E: The role of estrogen receptor-β in breast cancer. Semin Reprod Med. 30:5–13. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Tonetti DA, Rubenstein R, DeLeon M, Zhao H, Pappas SG, Bentrem DJ, Chen B, Constantinou A and Craig Jordan V: Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells. J Steroid Biochem Mol Biol. 87:47–55. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Hou YF, Yuan ST, Li HC, Wu J, Lu JS, Liu G, Lu LJ, Shen ZZ, Ding J and Shao ZM: ERbeta exerts multiple stimulative effects on human breast carcinoma cells. Oncogene. 23:5799–5806. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Fox EM, Davis RJ and Shupnik MA: ERbeta in breast cancer -onlooker, passive player, or active protector? Steroids. 73:1039–1051. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Skliris GP, Leygue E, Curtis-Snell L, Watson PH and Murphy LC: Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours. Br J Cancer. 95:616–626. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Monroe DG, Secreto FJ, Subramaniam M, Getz BJ, Khosla S and Spelsberg TC: Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells. Mol Endocrinol. 19:1555–1568. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Weitsman GE, Skliris G, Ung K, Peng B, Younes M, Watson PH and Murphy LC: Assessment of multiple different estrogen receptor-beta antibodies for their ability to immunoprecipitate under chromatin immunoprecipitation conditions. Breast Cancer Res Treat. 100:23–31. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Jonsson P, Katchy A and Williams C: Support of a bi-faceted role of estrogen receptor β (ERβ) in ERα-positive breast cancer cells. Endocr Relat Cancer. 21:143–160. 2014. View Article : Google Scholar :

40 

Chavey C, Bibeau F, Gourgou-Bourgade S, Burlinchon S, Boissière F, Laune D, Roques S and Lazennec G: Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res. 9:R152007. View Article : Google Scholar : PubMed/NCBI

41 

Kidd P: Th1/Th2 balance: The hypothesis, its limitations, and implications for health and disease. Altern Med Rev. 8:223–246. 2003.PubMed/NCBI

42 

Hartman J, Lindberg K, Morani A, Inzunza J, Ström A and Gustafsson JA: Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts. Cancer Res. 66:11207–11213. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Brueggemeier RW, Hackett JC and Diaz-Cruz ES: Aromatase inhibitors in the treatment of breast cancer. Endocr Rev. 26:331–345. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Gutierrez MC, Detre S, Johnston S, Mohsin SK, Shou J, Allred DC, Schiff R, Osborne CK and Dowsett M: Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. J Clin Oncol. 23:2469–2476. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Gallo D, De Stefano I, Grazia Prisco M, Scambia G and Ferrandina G: Estrogen receptor beta in cancer: An attractive target for therapy. Curr Pharm Des. 18:2734–2757. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Honma N, Horii R, Iwase T, Saji S, Younes M, Takubo K, Matsuura M, Ito Y, Akiyama F and Sakamoto G: Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. J Clin Oncol. 26:3727–3734. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Pitta CA, Papageorgis P, Charalambous C and Constantinou AI: Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance. Cancer Lett. 337:167–176. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Razandi M, Pedram A, Jordan VC, Fuqua S and Levin ER: Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast cancer. Oncogene. 32:3274–3285. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Niu XL, Wang Y, Yao Z, Duan H, Li Z, Liu W, Zhang H and Deng WM: Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype. Oncol Rep 34: 3120-3130, 2015.
APA
Niu, X.L., Wang, Y., Yao, Z., Duan, H., Li, Z., Liu, W. ... Deng, W.M. (2015). Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype. Oncology Reports, 34, 3120-3130. https://doi.org/10.3892/or.2015.4294
MLA
Niu, X. L., Wang, Y., Yao, Z., Duan, H., Li, Z., Liu, W., Zhang, H., Deng, W. M."Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype". Oncology Reports 34.6 (2015): 3120-3130.
Chicago
Niu, X. L., Wang, Y., Yao, Z., Duan, H., Li, Z., Liu, W., Zhang, H., Deng, W. M."Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype". Oncology Reports 34, no. 6 (2015): 3120-3130. https://doi.org/10.3892/or.2015.4294
Copy and paste a formatted citation
x
Spandidos Publications style
Niu XL, Wang Y, Yao Z, Duan H, Li Z, Liu W, Zhang H and Deng WM: Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype. Oncol Rep 34: 3120-3130, 2015.
APA
Niu, X.L., Wang, Y., Yao, Z., Duan, H., Li, Z., Liu, W. ... Deng, W.M. (2015). Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype. Oncology Reports, 34, 3120-3130. https://doi.org/10.3892/or.2015.4294
MLA
Niu, X. L., Wang, Y., Yao, Z., Duan, H., Li, Z., Liu, W., Zhang, H., Deng, W. M."Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype". Oncology Reports 34.6 (2015): 3120-3130.
Chicago
Niu, X. L., Wang, Y., Yao, Z., Duan, H., Li, Z., Liu, W., Zhang, H., Deng, W. M."Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype". Oncology Reports 34, no. 6 (2015): 3120-3130. https://doi.org/10.3892/or.2015.4294
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