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Article

Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC

  • Authors:
    • Kun Ding
    • Lu Fan
    • Shijun Chen
    • Yanna Wang
    • Haifeng Yu
    • Yanni Sun
    • Jiguang Yu
    • Li Wang
    • Xiangzhong Liu
    • Youde Liu
  • View Affiliations / Copyright

    Affiliations: Department of Liver Diseases, Jinan Infectious Disease Hospital, Shandong University School of Medicine, Jian, Shandong 250000, P.R. China, Yantai Infectious Disease Hospital, Yantai, Shandong 264001, P.R. China
  • Pages: 3297-3303
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    Published online on: September 23, 2015
       https://doi.org/10.3892/or.2015.4306
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Abstract

Osteopontin (OPN) is a multi-functional cytokine involved in cell survival, migration and adhesion. Increasing evidence has elucidated its role in tumorigenesis, progression and metastasis. However, the role of OPN in chemoresistance of human hepatocellular carcinoma (HCC) has not yet been clarified. In the present study, we examined the expression of OPN in human HCC samples before and after cisplatin-treatment, the results showed that OPN was significantly increased in cisplatin-resistant specimens. We then studied the effect of cisplatin on OPN expression in HCC cells, after exposure to cisplatin, the expression of OPN in HCC cells was elevated compared to control cells. We also found that PI3K/AKT signaling pathway was also activated by cisplatin and this effect was induced by the OPN pathway. To study the effect of OPN on chemoresistance, HCC cells were treated with cisplatin along with OPN. Incubation with OPN enchanced the chemoresistance of HCC cells to cisplatin. In contrast, blockage of OPN pathway promoted the chemosensitivity of HCC cells to cisplatin. Our results suggest that OPN enhanced chemoresistance of cisplatin in HCC cells by activating PI3K/AKT signaling pathway, blocking the OPN pathway might be a novel way to overcome the disease.
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1 

Venook AP, Papandreou C, Furuse J and de Guevara LL: The incidence and epidemiology of hepatocellular carcinoma: A global and regional perspective. Oncologist. 15(Suppl 4): 5–13. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Eggert T, McGlynn KA, Duffy A, Manns MP, Greten TF and Altekruse SF: Fibrolamellar hepatocellular carcinoma in the USA, 2000-2010: A detailed report on frequency, treatment and outcome based on the Surveillance, Epidemiology, and End Results database. United European Gastroenterol J. 1:351–357. 2013. View Article : Google Scholar

3 

Jaka H, Mshana SE, Rambau PF, Masalu N, Chalya PL and Kalluvya SE: Hepatocellular carcinoma: Clinicopathological profile and challenges of management in a resource-limited setting. World J Surg Oncol. 12:2462014. View Article : Google Scholar : PubMed/NCBI

4 

Naugler WE, Alsina AE, Frenette CT, Rossaro L and Sellers MT: Building the multidisciplinary team for management of patients with hepatocellular carcinoma. Clin Gastroenterol Hepatol. 13:827–835. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Crissien AM and Frenette C: Current management of hepatocellular carcinoma. Gastroenterol Hepatol (NY). 10:153–161. 2014.

6 

Knudsen ES, Gopal P and Singal AG: The changing landscape of hepatocellular carcinoma: Etiology, genetics, and therapy. Am J Pathol. 184:574–583. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Kew MC: The role of cirrhosis in the etiology of hepatocellular carcinoma. J Gastrointest Cancer. 45:12–21. 2014. View Article : Google Scholar

8 

Tornai I: Role of environmental factors in the etiology of hepatocellular carcinoma. Orv Hetil. 151:1132–1136. 2010.In Hungarian. View Article : Google Scholar : PubMed/NCBI

9 

Senkerikova R, Frankova S, Sperl J, Oliverius M, Kieslichova E, Filipova H, Kautznerova D, Honsova E, Trunecka P and Spicak J: Incidental hepatocellular carcinoma: Risk factors and long-term outcome after liver transplantation. Transplant Proc. 46:1426–1429. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Kamiyama T, Tahara M, Nakanishi K, Yokoo H, Kamachi H, Kakisaka T, Tsuruga Y, Matsushita M and Todo S: Long-term outcome of laparoscopic hepatectomy in patients with hepatocellular carcinoma. Hepatogastroenterology. 61:405–409. 2014.PubMed/NCBI

11 

Takaki S, Sakaguchi H, Anai H, Tanaka T, Yamamoto K, Morimoto K, Nishiofuku H, Inoue M, Sueyoshi S, Nagata T, et al: Long-term outcome of transcatheter subsegmental and segmental arterial chemoemobolization using lipiodol for hepatocellular carcinoma. Cardiovasc Intervent Radiol. 35:544–554. 2012. View Article : Google Scholar

12 

Otsuji K, Takai K, Nishigaki Y, Shimizu S, Hayashi H, Imai K, Suzuki Y, Hanai T, Ideta T, Miyazaki T, et al: Efficacy and safety of cisplatin versus miriplatin in transcatheter arterial chemoembolization and transarterial infusion chemotherapy for hepatocellular carcinoma: A randomized controlled trial. Hepatol Res. 45:514–522. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ishikawa T, Kubota T, Abe S, Watanabe Y, Sugano T, Inoue R, Iwanaga A, Seki K, Honma T and Yoshida T: Hepatic arterial infusion chemotherapy with cisplatin before radical local treatment of early hepatocellular carcinoma (JIS score 0/1) improves survival. Ann Oncol. 25:1379–1384. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Terazawa T, Kondo S, Hosoi H, Morizane C, Shimizu S, Mitsunaga S, Ikeda M, Ueno H and Okusaka T: Transarterial infusion chemotherapy with cisplatin plus S-1 for hepatocellular carcinoma treatment: A phase I trial. BMC Cancer. 14:3012014. View Article : Google Scholar : PubMed/NCBI

15 

An J, Wang X, Guo P, Zhong Y, Zhang X and Yu Z: Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the phosphatidylinositol 3-kinase/protein kinase B pathway. Toxicol Lett. 229:265–272. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Fang D, Guo Y, Zhu Z and Chen W: Silence of p15 expression by RNAi enhances cisplatin resistance in hepatocellular carcinoma cells. Bosn J Basic Med Sci. 12:4–9. 2012.PubMed/NCBI

17 

Kim Y, Jang M, Lim S, Won H, Yoon KS, Park JH, Kim HJ, Kim BH, Park WS, Ha J, et al: Role of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma in humans. Hepatology. 54:1661–1678. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Butler WT: Structural and functional domains of osteopontin. Ann N Y Acad Sci. 760:6–11. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Dai J, Cao Z, Kang Y, Fan K, Ji G, Yang H, Wang H, Gao J, Wang H and Guo Y: A functional motif QLYxxYP is essential for osteopontin induced T lymphocyte activation and migration. Biochem Biophys Res Commun. 380:715–720. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Cao Z, Dai J, Fan K, Wang H, Ji G, Li B, Zhang D, Hou S, Qian W, Zhao J, et al: A novel functional motif of osteopontin for human lymphocyte migration and survival. Mol Immunol. 45:3683–3692. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Kumar S, Sharma P, Kumar D, Chakraborty G, Gorain M and Kundu GC: Functional characterization of stromal osteopontin in melanoma progression and metastasis. PLoS One. 8:e691162013. View Article : Google Scholar : PubMed/NCBI

22 

Yu M, Liu Q, Yi K, Wu L and Tan X: Effects of osteopontin on functional activity of late endothelial progenitor cells. J Cell Biochem. 112:1730–1736. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Qiu Y, Hu Y, Zhang ZY, Ye L, Xu FH, Schneider ME, Ma XL, Du YX, Zuo XB, Zhou FS, et al: Genetic association of osteopontin (OPN) and its receptor CD44 genes with susceptibility to Chinese gastric cancer patients. J Cancer Res Clin Oncol. 140:2143–2156. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Liu J, Liu Q, Wan Y, Zhao Z, Yu H, Luo H and Tang Z: Osteopontin promotes the progression of gastric cancer through the NF-κB pathway regulated by the MAPK and PI3K. Int J Oncol. 45:282–290. 2014.PubMed/NCBI

25 

Pang H, Lu H, Song H, Meng Q, Zhao Y, Liu N, Lan F, Liu Y, Yan S, Dong X, et al: Prognostic values of osteopontin-c, E-cadherin and β-catenin in breast cancer. Cancer Epidemiol. 37:985–992. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Zhang H, Guo M, Chen JH, Wang Z, Du XF, Liu PX and Li WH: Osteopontin knockdown inhibits αv,β integrin-induced cell migration and invasion and promotes apoptosis of breast cancer cells by inducing autophagy and inactivating the PI3K/Akt/mTOR pathway. Cell Physiol Biochem. 33:991–1002. 2014. View Article : Google Scholar

27 

Hsieh IS, Huang WH, Liou HC, Chuang WJ, Yang RS and Fu WM: Upregulation of drug transporter expression by osteopontin in prostate cancer cells. Mol Pharmacol. 83:968–977. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Thoms JW, Dal Pra A, Anborgh PH, Christensen E, Fleshner N, Menard C, Chadwick K, Milosevic M, Catton C, Pintilie M, et al: Plasma osteopontin as a biomarker of prostate cancer aggression: Relationship to risk category and treatment response. Br J Cancer. 107:840–846. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Zhang T, Zhang DM, Zhao D, Hou XM, Liu XJ, Ling XL and Ma SC: The prognostic value of osteopontin expression in non-small cell lung cancer: A meta-analysis. J Mol Histol. 45:533–540. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Yu TT, Han ZG, Shan L, Tao J, Zhang T, Yuan SF and Shen HL: Expression of osteopontin in non-small cell lung cancer and correlative relation with microvascular density. Asian Pac J Cancer Prev. 15:29–32. 2014. View Article : Google Scholar : PubMed/NCBI

31 

El-Din Bessa SS, Elwan NM, Suliman GA and El-Shourbagy SH: Clinical significance of plasma osteopontin level in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma. Arch Med Res. 41:541–547. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Shang S, Plymoth A, Ge S, Feng Z, Rosen HR, Sangrajrang S, Hainaut P, Marrero JA and Beretta L: Identification of osteopontin as a novel marker for early hepatocellular carcinoma. Hepatology. 55:483–490. 2012. View Article : Google Scholar

33 

Kim SH, Chung YH, Yang SH, Kim JA, Jang MK, Kim SE, Lee D, Lee SH, Lee D, Kim KM, et al: Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization. Korean J Hepatol. 15:320–330. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Phillips RJ, Helbig KJ, Van der Hoek KH, Seth D and Beard MR: Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World J Gastroenterol. 18:3389–3399. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Yu MC, Lee YS, Lin SE, Wu HY, Chen TC, Lee WC, Chen MF and Tsai CN: Recurrence and poor prognosis following resection of small hepatitis B-related hepatocellular carcinoma lesions are associated with aberrant tumor expression profiles of glypican 3 and osteopontin. Ann Surg Oncol. 19(Suppl 3): S455–S463. 2012. View Article : Google Scholar

36 

Daniele B: Current issues in the management of hepatocellular carcinoma. Ann Oncol. 24(Suppl 2): ii52013. View Article : Google Scholar : PubMed/NCBI

37 

Qin L: Osteopontin is a promoter for hepatocellular carcinoma metastasis: A summary of 10 years of studies. Front Med. 8:24–32. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Zhang R, Pan X, Huang Z, Weber GF and Zhang G: Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines. PLoS One. 6:e238312011. View Article : Google Scholar : PubMed/NCBI

39 

Lin F, Li Y, Cao J, Fan S, Wen J, Zhu G, Du H and Liang Y: Overexpression of osteopontin in hepatocellular carcinoma and its relationships with metastasis, invasion of tumor cells. Mol Biol Rep. 38:5205–5210. 2011. View Article : Google Scholar

40 

Chen RX, Xia YH, Xue TC, Zhang H and Ye SL: Down-regulation of osteopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP-2 and uPA. Oncol Rep. 25:803–808. 2011.

41 

Cheng L, Luo S, Jin C, Ma H, Zhou H and Jia L: FUT family mediates the multidrug resistance of human hepatocellular carcinoma via the PI3K/Akt signaling pathway. Cell Death Dis. 4:e9232013. View Article : Google Scholar : PubMed/NCBI

42 

Wang XJ, Feng CW and Li M: ADAM17 mediates hypoxia-induced drug resistance in hepatocellular carcinoma cells through activation of EGFR/PI3K/Akt pathway. Mol Cell Biochem. 380:57–66. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Li QL, Gu FM, Wang Z, Jiang JH, Yao LQ, Tan CJ, Huang XY, Ke AW, Dai Z, Fan J, et al: Activation of PI3K/AKT and MAPK pathway through a PDGFRβ-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma. PLoS One. 7:e333792012. View Article : Google Scholar

44 

Gu T, Ohashi R, Cui R, Tajima K, Yoshioka M, Iwakami S, Sasaki S, Shinohara A, Matsukawa T, Kobayashi J, et al: Osteopontin is involved in the development of acquired chemo-resistance of cisplatin in small cell lung cancer. Lung Cancer. 66:176–183. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ding K, Fan L, Chen S, Wang Y, Yu H, Sun Y, Yu J, Wang L, Liu X, Liu Y, Liu Y, et al: Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC. Oncol Rep 34: 3297-3303, 2015.
APA
Ding, K., Fan, L., Chen, S., Wang, Y., Yu, H., Sun, Y. ... Liu, Y. (2015). Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC. Oncology Reports, 34, 3297-3303. https://doi.org/10.3892/or.2015.4306
MLA
Ding, K., Fan, L., Chen, S., Wang, Y., Yu, H., Sun, Y., Yu, J., Wang, L., Liu, X., Liu, Y."Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC". Oncology Reports 34.6 (2015): 3297-3303.
Chicago
Ding, K., Fan, L., Chen, S., Wang, Y., Yu, H., Sun, Y., Yu, J., Wang, L., Liu, X., Liu, Y."Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC". Oncology Reports 34, no. 6 (2015): 3297-3303. https://doi.org/10.3892/or.2015.4306
Copy and paste a formatted citation
x
Spandidos Publications style
Ding K, Fan L, Chen S, Wang Y, Yu H, Sun Y, Yu J, Wang L, Liu X, Liu Y, Liu Y, et al: Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC. Oncol Rep 34: 3297-3303, 2015.
APA
Ding, K., Fan, L., Chen, S., Wang, Y., Yu, H., Sun, Y. ... Liu, Y. (2015). Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC. Oncology Reports, 34, 3297-3303. https://doi.org/10.3892/or.2015.4306
MLA
Ding, K., Fan, L., Chen, S., Wang, Y., Yu, H., Sun, Y., Yu, J., Wang, L., Liu, X., Liu, Y."Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC". Oncology Reports 34.6 (2015): 3297-3303.
Chicago
Ding, K., Fan, L., Chen, S., Wang, Y., Yu, H., Sun, Y., Yu, J., Wang, L., Liu, X., Liu, Y."Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC". Oncology Reports 34, no. 6 (2015): 3297-3303. https://doi.org/10.3892/or.2015.4306
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