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Article

Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma

  • Authors:
    • Jieyu Zhou
    • Yongmei Li
    • Dongmin Wei
    • Ye Qian
    • Wenming Li
    • Dayu Liu
    • Guojun Li
    • Xinliang Pan
    • Dapeng Lei
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Qilu Hospital, Shandong University; Key Laboratory of Otolaryngology, Chinese Ministry of Health, Jinan, Shandong 250012, P.R. China, Department of Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
  • Pages: 3196-3202
    |
    Published online on: September 28, 2015
       https://doi.org/10.3892/or.2015.4313
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Abstract

The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtained and analyzed. Survival curves were analyzed using the Kaplan‑Meier method for survival and Cox models for hazard ratios (HRs) with 95% confidence intervals (CIs). LF was preserved in 403 cases and not preserved in 177 cases. The 3‑ and 5‑year survival rates were 70.9 and 52.7%, respectively, in the LF preservation group and 48.4 and 30.5%, respectively, in the no LF preservation group. Compared with the patients without LF preservation, patients with LF preservation had a significantly reduced risk of overall death (HR=0.63, 95% CI: 0.50-0.80). LF preservation positively affects the prognosis of patients with HSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Li Y, Wei D, Qian Y, Li W, Liu D, Li G, Pan X and Lei D: Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma. Oncol Rep 34: 3196-3202, 2015.
APA
Zhou, J., Li, Y., Wei, D., Qian, Y., Li, W., Liu, D. ... Lei, D. (2015). Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma. Oncology Reports, 34, 3196-3202. https://doi.org/10.3892/or.2015.4313
MLA
Zhou, J., Li, Y., Wei, D., Qian, Y., Li, W., Liu, D., Li, G., Pan, X., Lei, D."Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma". Oncology Reports 34.6 (2015): 3196-3202.
Chicago
Zhou, J., Li, Y., Wei, D., Qian, Y., Li, W., Liu, D., Li, G., Pan, X., Lei, D."Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma". Oncology Reports 34, no. 6 (2015): 3196-3202. https://doi.org/10.3892/or.2015.4313
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Li Y, Wei D, Qian Y, Li W, Liu D, Li G, Pan X and Lei D: Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma. Oncol Rep 34: 3196-3202, 2015.
APA
Zhou, J., Li, Y., Wei, D., Qian, Y., Li, W., Liu, D. ... Lei, D. (2015). Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma. Oncology Reports, 34, 3196-3202. https://doi.org/10.3892/or.2015.4313
MLA
Zhou, J., Li, Y., Wei, D., Qian, Y., Li, W., Liu, D., Li, G., Pan, X., Lei, D."Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma". Oncology Reports 34.6 (2015): 3196-3202.
Chicago
Zhou, J., Li, Y., Wei, D., Qian, Y., Li, W., Liu, D., Li, G., Pan, X., Lei, D."Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma". Oncology Reports 34, no. 6 (2015): 3196-3202. https://doi.org/10.3892/or.2015.4313
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