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Article

10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity

  • Authors:
    • Ji-Hye Joo
    • Seong-Su Hong
    • Young-Rak Cho
    • Dong-Wan Seo
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea, Gyeonggi Biocenter, Gyeonggi Institute of Science and Technology Promotion, Suwon 16229, Republic of Korea
  • Pages: 779-784
    |
    Published online on: November 9, 2015
       https://doi.org/10.3892/or.2015.4405
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Abstract

In the present study, we investigated the roles and molecular mechanism of 10-gingerol, a phenolic compound isolated from Zingiber officinale, in regulating cell proliferation and invasion of MDA‑MB‑231 breast cancer cells. 10-gingerol treatment inhibited cell proliferation through downregulation of cell cycle regulatory proteins such as cyclin-dependent kinases and cyclins, and subsequent induction of G1 phase arrest. In addition, 10‑gingerol treatment blocked cell invasion in response to mitogenic stimulation. These antitumor activities of 10‑gingerol were mediated through inactivation of Akt and p38MAPK activity, and suppression of epidermal growth factor receptor expression. Collectively, these findings demonstrate the pharmacological roles of 10-gingerol in regulating breast cancer cell growth and progression, and suggest further evaluation and development as a potential therapeutic agent for the prevention and treatment of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Joo J, Hong S, Cho Y and Seo D: 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncol Rep 35: 779-784, 2016.
APA
Joo, J., Hong, S., Cho, Y., & Seo, D. (2016). 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncology Reports, 35, 779-784. https://doi.org/10.3892/or.2015.4405
MLA
Joo, J., Hong, S., Cho, Y., Seo, D."10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity". Oncology Reports 35.2 (2016): 779-784.
Chicago
Joo, J., Hong, S., Cho, Y., Seo, D."10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity". Oncology Reports 35, no. 2 (2016): 779-784. https://doi.org/10.3892/or.2015.4405
Copy and paste a formatted citation
x
Spandidos Publications style
Joo J, Hong S, Cho Y and Seo D: 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncol Rep 35: 779-784, 2016.
APA
Joo, J., Hong, S., Cho, Y., & Seo, D. (2016). 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncology Reports, 35, 779-784. https://doi.org/10.3892/or.2015.4405
MLA
Joo, J., Hong, S., Cho, Y., Seo, D."10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity". Oncology Reports 35.2 (2016): 779-784.
Chicago
Joo, J., Hong, S., Cho, Y., Seo, D."10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity". Oncology Reports 35, no. 2 (2016): 779-784. https://doi.org/10.3892/or.2015.4405
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