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Article

β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1

  • Authors:
    • Woong Bang
    • Young-Joo Jeon
    • Jin Hyoung Cho
    • Ra Ham Lee
    • Seon-Min Park
    • Jae-Cheon Shin
    • Nag-Jin Choi
    • Yung Hyun Choi
    • Jung-Jae Cho
    • Jae-Min Seo
    • Seung-Yeop Lee
    • Jung-Hyun Shim
    • Jung-Il Chae
  • View Affiliations / Copyright

    Affiliations: Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University, Jeonju 561-756, Republic of Korea, Pohang Center for Evaluation of Biomaterials, Pohang, Gyeongbuk 790‑834, Republic of Korea, Department of Animal Science, College of Agricultural and Life Science, Chonbuk National University, Jeonju 561‑756, Republic of Korea, Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614-052, Republic of Korea, Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 534-729, Republic of Korea, Department of Prosthodontics, School of Dentistry and Institute of Oral Bio-Science and Research Institute of Clinical Medicine, Chonbuk National University, Jeonju 561-756, Republic of Korea, Cluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Chonbuk National University, Jeonju 561-756, Republic of Korea
  • Pages: 1109-1116
    |
    Published online on: November 20, 2015
       https://doi.org/10.3892/or.2015.4439
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Abstract

β-lapachone (β-lap), a novel natural quinone derived from the bark of the Pink trumpet tree (Tabebuia avellanedae) has been demonstrated to have anticancer activity. In this study, we investigated whether β-lap exhibits anti-proliferative effects on two human malignant melanoma (HMM) cell lines, G361 and SK-MEL-28. The effects of β-lap on the HMM cell lines were investigated using 3-(4,5-dimethylthiazol-2-yl)‑5-(3-carboxymethoxyphenyl)‑2-(4-sulfophenyl-2H-tetrazolium (MTS) assay, 4',6-diamidino-2-phenylindole (DAPI) staining, Annexin V and Dead cell assay, mitochondrial membrane potential (MMP) assay and western blot analysis. We demonstrated that β-lap significantly induced apoptosis and suppressed cell viability in the HMM cells. Intriguingly, the transcription factor specificity protein 1 (Sp1) was significantly downregulated by β-lap in a dose- and time-dependent manner. Furthermore, β-lap modulated the protein expression level of the Sp1 regulatory genes including cell cycle regulatory proteins and apoptosis-associated proteins. Taken together, our findings indicated that β-lap modulates Sp1 transactivation and induces apoptotic cell death through the regulation of cell cycle- and apoptosis-associated proteins. Thus, β-lap may be used as a promising anticancer drug for cancer prevention and may improve the clinical outcome of patients with cancer.
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1 

Bandarchi B, Ma L, Navab R, Seth A and Rasty G: From melanocyte to metastatic malignant melanoma. Dermatol Res Pract. 2010:5837482010.PubMed/NCBI

2 

Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D and Bray F: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer. 49:1374–1403. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Erdmann F, Lortet-Tieulent J, Schüz J, Zeeb H, Greinert R, Breitbart EW and Bray F: International trends in the incidence of malignant melanoma 1953–2008 - are recent generations at higher or lower risk? Int J Cancer. 132:385–400. 2013. View Article : Google Scholar

4 

Kesmodel SB and Spitz FR: Gene therapy for cancer and metastatic disease. Expert Rev Mol Med. 5:1–18. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Bhatia S, Tykodi SS and Thompson JA: Treatment of metastatic melanoma: An overview. Oncology (Williston Park). 23:488–496. 2009.

6 

Moon DO, Kang CH, Kim MO, Jeon YJ, Lee JD, Choi YH and Kim GY: Beta-lapachone (LAPA) decreases cell viability and telomerase activity in leukemia cells: Suppression of telomerase activity by LAPA. J Med Food. 13:481–488. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Guiraud P, Steiman R, Campos-Takaki GM, Seigle-Murandi F and Simeon de Buochberg M: Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. Planta Med. 60:373–374. 1994. View Article : Google Scholar : PubMed/NCBI

8 

de Almeida ER, da Silva Filho AA, dos Santos ER and Lopes CA: Antiinflammatory action of lapachol. J Ethnopharmacol. 29:239–241. 1990. View Article : Google Scholar : PubMed/NCBI

9 

Li CJ, Zhang LJ, Dezube BJ, Crumpacker CS and Pardee AB: Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication. Proc Natl Acad Sci USA. 90:1839–1842. 1993. View Article : Google Scholar : PubMed/NCBI

10 

Planchon SM, Wuerzberger S, Frydman B, Witiak DT, Hutson P, Church DR, Wilding G and Boothman DA: Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: A p53-independent response. Cancer Res. 55:3706–3711. 1995.PubMed/NCBI

11 

Planchon SM, Pink JJ, Tagliarino C, Bornmann WG, Varnes ME and Boothman DA: Beta-lapachone-induced apoptosis in human prostate cancer cells: Involvement of NQO1/xip3. Exp Cell Res. 267:95–106. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Müller K, Sellmer A and Wiegrebe W: Potential antipsoriatic agents: Lapacho compounds as potent inhibitors of HaCaT cell growth. J Nat Prod. 62:1134–1136. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Sitônio MM, Carvalho Júnior CH, Campos IA, Silva JB, Lima MC, Góes AJ, Maia MB, Rolim Neto PJ and Silva TG: Anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone). Inflamm Res. 62:107–113. 2013. View Article : Google Scholar

14 

Frydman B, Marton LJ, Sun JS, Neder K, Witiak DT, Liu AA, Wang HM, Mao Y, Wu HY, Sanders MM, et al: Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones. Cancer Res. 57:620–627. 1997.PubMed/NCBI

15 

Chau YP, Shiah SG, Don MJ and Kuo ML: Involvement of hydrogen peroxide in topoisomerase inhibitor beta-lapachone-induced apoptosis and differentiation in human leukemia cells. Free Radic Biol Med. 24:660–670. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Shiah SG, Chuang SE, Chau YP, Shen SC and Kuo ML: Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation-dependent pathway. Cancer Res. 59:391–398. 1999.PubMed/NCBI

17 

Choi YH, Kang HS and Yoo MA: Suppression of human prostate cancer cell growth by beta-lapachone via down-regulation of pRB phosphorylation and induction of Cdk inhibitor p21(WAF1/CIP1). J Biochem Mol Biol. 36:223–229. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Pink JJ, Wuerzberger-Davis S, Tagliarino C, Planchon SM, Yang X, Froelich CJ and Boothman DA: Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis. Exp Cell Res. 255:144–155. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Wuerzberger SM, Pink JJ, Planchon SM, Byers KL, Bornmann WG and Boothman DA: Induction of apoptosis in MCF-7:WS8 breast cancer cells by beta-lapachone. Cancer Res. 58:1876–1885. 1998.PubMed/NCBI

20 

Dong GZ, Oh ET, Lee H, Park MT, Song CW and Park HJ: Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB. Exp Mol Med. 42:327–334. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Yu HY, Kim SO, Jin CY, Kim GY, Kim WJ, Yoo YH and Choi YH: β-lapachone-induced apoptosis of human gastric carcinoma AGS cells is caspase-dependent and regulated by the PI3K/Akt pathway. Biomol Ther (Seoul). 22:184–192. 2014. View Article : Google Scholar

22 

Wierstra I: Sp1: Emerging roles - beyond constitutive activation of TATA-less housekeeping genes. Biochem Biophys Res Commun. 372:1–13. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Black AR, Black JD and Azizkhan-Clifford J: Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol. 188:143–160. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Kong LM, Liao CG, Fei F, Guo X, Xing JL and Chen ZN: Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer. Cancer Sci. 101:1463–1470. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Sankpal UT, Goodison S, Abdelrahim M and Basha R: Targeting Sp1 transcription factors in prostate cancer therapy. Med Chem. 7:518–525. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Jiang Y, Wang L, Gong W, Wei D, Le X, Yao J, Ajani J, Abbruzzese JL, Huang S and Xie K: A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. Clin Exp Metastasis. 21:755–764. 2004. View Article : Google Scholar

27 

Kim DW, Ko SM, Jeon YJ, Noh YW, Choi NJ, Cho SD, Moon HS, Cho YS, Shin JC, Park SM, et al: Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1. Int J Oncol. 43:1103–1110. 2013.PubMed/NCBI

28 

Zhang R, Luo H, Wang S, Chen W, Chen Z, Wang HW, Chen Y, Yang J, Zhang X, Wu W, et al: MicroRNA-377 inhibited proliferation and invasion of human glioblastoma cells by directly targeting specificity protein 1. Neuro Oncol. 16:1510–1522. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Abdelrahim M, Smith R III, Burghardt R and Safe S: Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells. Cancer Res. 64:6740–6749. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Shin JA, Han G, Kim HJ, Kim HM and Cho SD: Chemopreventive and chemotherapeutic effect of a novel histone deacetylase inhibitor, by specificity protein 1 in MDA-MB-231 human breast cancer cells. Eur J Cancer Prev. 23:277–285. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Cho JH, Shin JC, Cho JJ, Choi YH, Shim JH and Chae JI: Esculetin (6,7-dihydroxycoumarin): A potential cancer chemo-preventive agent through suppression of Sp1 in oral squamous cancer cells. Int J Oncol. 46:265–271. 2015.

32 

Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P and Longo VD: Fasting and cancer treatment in humans: A case series report. Aging (Albany NY). 1:988–1007. 2009.

33 

Wilson RM and Danishefsky SJ: Small molecule natural products in the discovery of therapeutic agents: The synthesis connection. J Org Chem. 71:8329–8351. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Tobin DD, Menon M, Menon M, Spatta BC, Hodges EV and Perry DG: The intrapsychics of gender: A model of self-socialization. Psychol Rev. 117:601–622. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Li CJ, Averboukh L and Pardee AB: Beta-lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 268:22463–22468. 1993.PubMed/NCBI

36 

Jackson JK, Higo T, Hunter WL and Burt HM: Topoisomerase inhibitors as anti-arthritic agents. Inflamm Res. 57:126–134. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Tudan C, Jackson JK, Higo TT and Burt HM: The effect of inhibiting topoisomerase I and II on the anti-apoptotic response associated with pro-inflammatory crystals of calcium pyrophosphate dihydrate in human neutrophils. Inflamm Res. 52:8–17. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Safe S and Abdelrahim M: Sp transcription factor family and its role in cancer. Eur J Cancer. 41:2438–2448. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Li L and Davie JR: The role of Sp1 and Sp3 in normal and cancer cell biology. Ann Anat. 192:275–283. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Hsu TI, Wang MC, Chen SY, Yeh YM, Su WC, Chang WC and Hung JJ: Sp1 expression regulates lung tumor progression. Oncogene. 31:3973–3988. 2012. View Article : Google Scholar :

41 

Kavurma MM and Khachigian LM: Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation. J Biol Chem. 278:32537–32543. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Xu R, Zhang P, Huang J, Ge S, Lu J and Qian G: Sp1 and Sp3 regulate basal transcription of the survivin gene. Biochem Biophys Res Commun. 356:286–292. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Chae JI, Jeon YJ and Shim JH: Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncol Rep. 29:2318–2324. 2013.PubMed/NCBI

44 

Hong IK, Byun HJ, Lee J, Jin YJ, Wang SJ, Jeoung DI, Kim YM and Lee H: The tetraspanin CD81 protein increases melanoma cell motility by up-regulating metalloproteinase MT1-MMP expression through the pro-oncogenic Akt-dependent Sp1 activation signaling pathways. J Biol Chem. 289:15691–15704. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Liu X, Yang WT and Zheng PS: Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas. Oncotarget. 5:10870–10885. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Sherr CJ and Roberts JM: CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–1512. 1999. View Article : Google Scholar : PubMed/NCBI

47 

Murray AW: Recycling the cell cycle: Cyclins revisited. Cell. 116:221–234. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Ewen ME and Lamb J: The activities of cyclin D1 that drive tumorigenesis. Trends Mol Med. 10:158–162. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Weinstein IB: Relevance of cyclin D1 and other molecular markers to cancer chemoprevention. J Cell Biochem Suppl. 25:23–28. 1996. View Article : Google Scholar : PubMed/NCBI

50 

Fu M, Wang C, Li Z, Sakamaki T and Pestell RG: Minireview: Cyclin D1: normal and abnormal functions. Endocrinology. 145:5439–5447. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC and Altieri DC: Control of apoptosis and mitotic spindle checkpoint by survivin. Nature. 396:580–584. 1998. View Article : Google Scholar : PubMed/NCBI

52 

Jarrin M, Mansergh FC, Boulton ME, Gunhaga L and Wride MA: Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation. Mol Vis. 18:2758–2769. 2012.PubMed/NCBI

53 

Xu Q, Liu M, Xu N and Zhu H: Variation in Sp1 binding sites correlates with expression of survivin in breast cancer. Mol Med Rep. 10:1395–1399. 2014.PubMed/NCBI

54 

Grütter MG: Caspases: Key players in programmed cell death. Curr Opin Struct Biol. 10:649–655. 2000. View Article : Google Scholar : PubMed/NCBI

55 

Porter AG and Jänicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6:99–104. 1999. View Article : Google Scholar : PubMed/NCBI

56 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG and Benchimol S: ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 16:6018–6033. 1997. View Article : Google Scholar : PubMed/NCBI

58 

Zauli G, Gibellini D, Caputo A, Bassini A, Negrini M, Monne M, Mazzoni M and Capitani S: The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells. Blood. 86:3823–3834. 1995.PubMed/NCBI

59 

Yang E, Zha J, Jockel J, Boise LH, Thompson CB and Korsmeyer SJ: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 80:285–291. 1995. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bang W, Jeon Y, Cho JH, Lee RH, Park S, Shin J, Choi N, Choi YH, Cho J, Seo J, Seo J, et al: β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1. Oncol Rep 35: 1109-1116, 2016.
APA
Bang, W., Jeon, Y., Cho, J.H., Lee, R.H., Park, S., Shin, J. ... Chae, J. (2016). β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1. Oncology Reports, 35, 1109-1116. https://doi.org/10.3892/or.2015.4439
MLA
Bang, W., Jeon, Y., Cho, J. H., Lee, R. H., Park, S., Shin, J., Choi, N., Choi, Y. H., Cho, J., Seo, J., Lee, S., Shim, J., Chae, J."β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1". Oncology Reports 35.2 (2016): 1109-1116.
Chicago
Bang, W., Jeon, Y., Cho, J. H., Lee, R. H., Park, S., Shin, J., Choi, N., Choi, Y. H., Cho, J., Seo, J., Lee, S., Shim, J., Chae, J."β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1". Oncology Reports 35, no. 2 (2016): 1109-1116. https://doi.org/10.3892/or.2015.4439
Copy and paste a formatted citation
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Spandidos Publications style
Bang W, Jeon Y, Cho JH, Lee RH, Park S, Shin J, Choi N, Choi YH, Cho J, Seo J, Seo J, et al: β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1. Oncol Rep 35: 1109-1116, 2016.
APA
Bang, W., Jeon, Y., Cho, J.H., Lee, R.H., Park, S., Shin, J. ... Chae, J. (2016). β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1. Oncology Reports, 35, 1109-1116. https://doi.org/10.3892/or.2015.4439
MLA
Bang, W., Jeon, Y., Cho, J. H., Lee, R. H., Park, S., Shin, J., Choi, N., Choi, Y. H., Cho, J., Seo, J., Lee, S., Shim, J., Chae, J."β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1". Oncology Reports 35.2 (2016): 1109-1116.
Chicago
Bang, W., Jeon, Y., Cho, J. H., Lee, R. H., Park, S., Shin, J., Choi, N., Choi, Y. H., Cho, J., Seo, J., Lee, S., Shim, J., Chae, J."β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1". Oncology Reports 35, no. 2 (2016): 1109-1116. https://doi.org/10.3892/or.2015.4439
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