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Article

An integrated analysis of cancer genes in thyroid cancer

  • Authors:
    • Li Chai
    • Jia Li
    • Zhongwei Lv
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, P.R. China, Department of Thyroid and Breast, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, P.R. China
  • Pages: 962-970
    |
    Published online on: December 1, 2015
       https://doi.org/10.3892/or.2015.4466
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Abstract

Cancer driver genes are commonly mutationally disrupted in cancer, which confers a growth advantage to tumor cells. Recent studies preferentially search for recurrently mutated driver genes across multiple tumor samples, leading to the neglect of low-frequency mutated cancer genes. The present study was conducted to identify cancer‑driving genes in thyroid cancer with two distinct tools, OncodriveFM and Dendrix, which aim to detect neglected driver genes with low mutation frequency. A total of 23,620 somatic mutations generated by whole‑exome sequencing of 446 tumor/normal pairs of thyroid cancer were obtained from TCGA. Variant classification was conducted with Ensembl Variant Effect Predictor (VEP). OncodriveFM and Dendrix were applied to detect driver genes and pathways with statistical evidence. In addition, we analyzed DNA‑methylation status, copy number variation, expression levels and fusion genes among these driver candidates. In total, non‑synonymous mutations accounted for over 55% (13,091/23,620) of the total variants; 53 and 3 driver genes were determined by OncodriveFM and Dendrix, respectively, including 6 recurrently mutated driver genes, such as BRAF, NRAS, HRAS, EIF1AX, KRAS and 47 new genes. A total of 75 pathways with high function impact bias were identified by OncodriveFM. Two genes, FHOD3 and SRP72, were hypomethylated, overexpressed and involved in major deletions in thyroid cancer. Moreover, we identified 91 pairs of fusion genes, 89 of which were new fusion pairs in thyroid cancer. In conclusion, we successfully identified a list of new cancer genes, pathways and fusion genes, providing better insight into the tumorigenesis of thyroid cancer.
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View References

1 

Girardi FM, Barra MB and Zettler CG: Analysis of pattern of occurrence of thyroid carcinoma between 2001 and 2010. Braz J Otorhinolaryngol. 81:541–548. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Hay ID, Thompson GB, Grant CS, Bergstralh EJ, Dvorak CE, Gorman CA, Maurer MS, McIver B, Mullan BP, Oberg AL, et al: Papillary thyroid carcinoma managed at the Mayo Clinic during six decades (1940–1999): Temporal trends in initial therapy and long-term outcome in 2444 consecutively treated patients. World J Surg. 26:879–885. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, Jia M, Shepherd R, Leung K, Menzies A, et al: COSMIC: Mining complete cancer genomes in the catalogue of somatic mutations in cancer. Nucleic Acids Res. 39(Database): D945–D950. 2011. View Article : Google Scholar :

4 

Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, et al: Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 499:214–218. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Dees ND, Zhang Q, Kandoth C, Wendl MC, Schierding W, Koboldt DC, Mooney TB, Callaway MB, Dooling D, Mardis ER, et al: MuSiC: Identifying mutational significance in cancer genomes. Genome Res. 22:1589–1598. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Cancer T and Atlas G; Cancer Genome Atlas Research Network: Integrated genomic characterization of papillary thyroid carcinoma. Cell. 159:676–690. 2014. View Article : Google Scholar

7 

Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, et al: The genomic landscapes of human breast and colorectal cancers. Science. 318:1108–1113. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Gonzalez-Perez A and Lopez-Bigas N: Functional impact bias reveals cancer drivers. Nucleic Acids Res. 40:e1692012. View Article : Google Scholar : PubMed/NCBI

9 

Ng PC and Henikoff S: SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res. 31:3812–3814. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS and Sunyaev SR: A method and server for predicting damaging missense mutations. Nat Methods. 7:248–249. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Reva B, Antipin Y and Sander C: Predicting the functional impact of protein mutations: Application to cancer genomics. Nucleic Acids Res. 39:e1182011. View Article : Google Scholar : PubMed/NCBI

12 

Vandin F, Upfal E and Raphael BJ: De novo discovery of mutated driver pathways in cancer. Genome Res. 22:375–385. 2012. View Article : Google Scholar :

13 

McLaren W, Pritchard B, Rios D, Chen Y, Flicek P and Cunningham F: Deriving the consequences of genomic variants with the Ensembl API and SNP effect predictor. Bioinformatics. 26:2069–2070. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al The Gene Ontology Consortium: Gene ontology: Tool for the unification of biology. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Costa V, Esposito R, Ziviello C, Sepe R, Bim LV, Cacciola NA, Decaussin-Petrucci M, Pallante P, Fusco A and Ciccodicola A: New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma. Oncotarget. 6:11242–11251. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R and Salzberg SL: TopHat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14:R362013. View Article : Google Scholar : PubMed/NCBI

17 

Quinlan AR and Hall IM: BEDTools: A flexible suite of utilities for comparing genomic features. Bioinformatics. 26:841–842. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Love MI, Huber W and Anders S: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15:5502014. View Article : Google Scholar : PubMed/NCBI

19 

Lawrence MS, Stojanov P, Mermel CH, Robinson JT, Garraway LA, Golub TR, Meyerson M, Gabriel SB, Lander ES and Getz G: Discovery and saturation analysis of cancer genes across 21 tumour types. Nature. 505:495–501. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Zhong Q, Peng H-L, Zhao X, Zhang L and Hwang W-T: Effects of BRCA1/2 on ovarian and breast cancer survival-response. Clin Cancer Res. 21:3807. 2015. View Article : Google Scholar

21 

Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, et al: Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet. 44:760–764. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Zang ZJ, Cutcutache I, Poon SL, Zhang SL, McPherson JR, Tao J, Rajasegaran V, Heng HL, Deng N, Gan A, et al: Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat Genet. 44:570–574. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Golding SE, Rosenberg E, Adams BR, Wignarajah S, Beckta JM, O'Connor MJ and Valerie K: Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensiti-zation and growth control. Cell Cycle. 11:1167–1173. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Negi SS and Brown P: rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis. Oncotarget. 6:18094–18104. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, Maris JM, Richardson A, Bardelli A, Sugarbaker DJ, et al: Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res. 64:8816–8820. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Seki M, Yoshida K, Shiraishi Y, Shimamura T, Sato Y, Nishimura R, Okuno Y, Chiba K, Tanaka H, Kato K, et al: Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma. Cancer Res. 74:2742–2749. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Hasan R, Sharma R, Saraya A, Chattopadhyay TK, DattaGupta S, Walfish PG, Chauhan SS and Ralhan R: Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis. BMC Cancer. 14:22014. View Article : Google Scholar : PubMed/NCBI

28 

Samanta AK, Huang HJ, Bast RC Jr and Liao WS-L: Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. J Biol Chem. 279:7576–7583. 2004. View Article : Google Scholar

29 

Arndt S and Bosserhoff AK: Reduced expression of TANGO in colon and hepatocellular carcinomas. Oncol Rep. 18:885–891. 2007.PubMed/NCBI

30 

Arndt S and Bosserhoff AK: TANGO is a tumor suppressor of malignant melanoma. Int J Cancer. 119:2812–2820. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Gonzalo S: Epigenetic alterations in aging. J Appl Physiol. 1985(109): 586–597. 2010. View Article : Google Scholar

32 

Xing M, Alzahrani AS, Carson KA, Shong YK, Kim TY, Viola D, Elisei R, Bendlová B, Yip L, Mian C, et al: Association between BRAF V600E mutation and recurrence of papillary thyroid cancer. J Clin Oncol. 33:42–50. 2015. View Article : Google Scholar

33 

Inumaru JS, Gordo KI, Fraga Junior AC, Silva AM, Leal CB, Ayres FM, Wastowski IJ, Borges NF and Saddi VA: Analysis of the BRAF V600E mutation in primary cutaneous melanoma. Genet Mol Res. 13:2840–2848. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Parikh C, Subrahmanyam R and Ren R: Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice. Cancer Res. 67:7139–7146. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Zhang C, Chen Y, Wang M, Chen X, Li Y, Song E, Liu X, Kim S and Peng H: PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells. World J Surg Oncol. 12:2582014. View Article : Google Scholar : PubMed/NCBI

36 

Ruark E, Snape K, Humburg P, Loveday C, Bajrami I, Brough R, Rodrigues DN, Renwick A, Seal S, Ramsay E, et al Breast and Ovarian Cancer Susceptibility Collaboration: Wellcome Trust Case Control Consortium: Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature. 93:406–410. 2013.

37 

Brabender J, Danenberg KD, Metzger R, Schneider PM, Lord RV, Groshen S, Tsao-Wei DD, Park J, Salonga D, Hölscher AH, et al: The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer. Clin Cancer Res. 8:438–443. 2002.PubMed/NCBI

38 

Papi A, Rocchi P, Ferreri AM and Orlandi M: RXRgamma and PPARgamma ligands in combination to inhibit proliferation and invasiveness in colon cancer cells. Cancer Lett. 297:65–74. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Liu Z, Zhou G, Nakamura M, Bai Y, Li Y, Ozaki T, Mori I, Miyauchi A and Kakudo K: Retinoid X receptor γ up-regulation is correlated with dedifferentiation of tumor cells and lymph node metastasis in papillary thyroid carcinoma. Pathol Int. 61:109–115. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Klopper JP, Hays WR, Sharma V, Baumbusch MA, Hershman JM and Haugen BR: Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment. Mol Cancer Ther. 3:1011–1020. 2004.PubMed/NCBI

41 

Szekeres K, Koul R, Mauro J, Lloyd M, Johnson J and Blanck G: An Oct-1-based, feed-forward mechanism of apoptosis inhibited by co-culture with Raji B-cells: Towards a model of the cancer cell/B-cell microenvironment. Exp Mol Pathol. 97:585–589. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Sellar GC, Watt KP, Rabiasz GJ, Stronach EA, Li L, Miller EP, Massie CE, Miller J, Contreras-Moreira B, Scott D, et al: OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Nat Genet. 34:337–343. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Fan S, Meng D, Xu T, Chen Y, Wang J, Li X, Chen H, Lu D, Chen J and Lan Q: Overexpression of SLC7A7 predicts poor progression-free and overall survival in patients with glio-blastoma. Med Oncol. 30:3842013. View Article : Google Scholar

44 

Fan S, Zhao Y, Li X, Du Y, Wang J, Song X, Zhou F, Chen H, Chen G, Zhao Y, et al: Genetic variants in SLC7A7 are associated with risk of glioma in a Chinese population. Exp Biol Med (Maywood). 238:1075–1081. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chai L, Li J and Lv Z: An integrated analysis of cancer genes in thyroid cancer. Oncol Rep 35: 962-970, 2016.
APA
Chai, L., Li, J., & Lv, Z. (2016). An integrated analysis of cancer genes in thyroid cancer. Oncology Reports, 35, 962-970. https://doi.org/10.3892/or.2015.4466
MLA
Chai, L., Li, J., Lv, Z."An integrated analysis of cancer genes in thyroid cancer". Oncology Reports 35.2 (2016): 962-970.
Chicago
Chai, L., Li, J., Lv, Z."An integrated analysis of cancer genes in thyroid cancer". Oncology Reports 35, no. 2 (2016): 962-970. https://doi.org/10.3892/or.2015.4466
Copy and paste a formatted citation
x
Spandidos Publications style
Chai L, Li J and Lv Z: An integrated analysis of cancer genes in thyroid cancer. Oncol Rep 35: 962-970, 2016.
APA
Chai, L., Li, J., & Lv, Z. (2016). An integrated analysis of cancer genes in thyroid cancer. Oncology Reports, 35, 962-970. https://doi.org/10.3892/or.2015.4466
MLA
Chai, L., Li, J., Lv, Z."An integrated analysis of cancer genes in thyroid cancer". Oncology Reports 35.2 (2016): 962-970.
Chicago
Chai, L., Li, J., Lv, Z."An integrated analysis of cancer genes in thyroid cancer". Oncology Reports 35, no. 2 (2016): 962-970. https://doi.org/10.3892/or.2015.4466
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