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Article

Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer

  • Authors:
    • Meng-Chi Yen
    • Ying-Chu Shih
    • Ya-Ling Hsu
    • En-Shyh Lin
    • Yi-Shiuan Lin
    • Eing-Mei Tsai
    • Ya-Wen Ho
    • Ming-Feng Hou
    • Po-Lin Kuo
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C., Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C., Department of Beauty Science, National Taichung University of Science and Technology, Taichung 403, Taiwan, R.O.C., Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
  • Pages: 1356-1364
    |
    Published online on: December 22, 2015
       https://doi.org/10.3892/or.2015.4503
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Abstract

Development of an efficient treatment for triple-negative breast cancer is an urgent issues. Compounds from plant extracts are a potential source of novel cancer treatment. Isolinderalactone, a kind of sesquiterpenoids compound, was purified from the root of Lindera strychnifolia and Neolitsea daibuensis and shows anti-inflammatory and anticancer capacity. In the present study, isolinderalactone induced apoptosis in MDA-MB-231 cells which is a kind of triple-negative breast cancer cell line through induction of an intrinsic mitochondria-mediated and caspase-independent cell death. Treatment of isolinderalactone increased the protein level of the suppressor of cytokine signaling 3 (SCOS3), decreased phosphorylation of the signal transducer and activator of transcription 3 (STAT3), and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein in MDA-MB-231 cells. Our results further showed that the level of SOCS3 expression was induced by isolinderalactone due to inhibiting the microRNA hsa-miR-30c-5p (miR-30c) expression. In addition, intraperitoneal injection of isolinderalactone induced apoptosis in a xenograft breast tumor while it did not significantly affect the histology of liver, kidney and lung of the treated mice. In conclusion, isolinderalactone induces apoptosis in MDA-MB‑231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c. It may become a novel treatment for triple-negative breast cancer in the future.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Anders CK and Carey LA: Biology, metastatic patterns, and treatment of patients with triple-negative breast cancer. Clin Breast Cancer. 9(Suppl 2): S73–S81. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Wahba HA and El-Hadaad HA: Current approaches in treatment of triple-negative breast cancer. Cancer Biol Med. 12:106–116. 2015.PubMed/NCBI

4 

Ismail-Khan R and Bui MM: A review of triple-negative breast cancer. Cancer Control. 17:173–176. 2010.PubMed/NCBI

5 

Ohno T, Nagatsu A, Nakagawa M, Inoue M, Li YM, Minatoguchi S, Mizukami H and Fujiwara H: New sesquiterpene lactones from water extract of the root of Lindera strychnifolia with cytotoxicity against the human small cell lung cancer cell, SBC-3. Tetrahedron Lett. 46:8657–8660. 2005. View Article : Google Scholar

6 

Wang F, Gao Y, Zhang L, Bai B, Hu YN, Dong ZJ, Zhai QW, Zhu HJ and Liu JK: A pair of windmill-shaped enantiomers from Lindera aggregata with activity toward improvement of insulin sensitivity. Org Lett. 12:3196–3199. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Wang F, Gao Y, Zhang L and Liu JK: Bi-linderone, a highly modified methyl-linderone dimer from Lindera aggregata with activity toward improvement of insulin sensitivity in vitro. Org Lett. 12:2354–2357. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Ohno T, Takemura G, Murata I, Kagawa T, Akao S, Minatoguchi S, Fujiwara T and Fujiwara H: Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice. Life Sci. 77:1391–1403. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Kobayashi W, Miyase T, Sano M, Umehara K, Warashina T and Noguchi H: Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill. Biol Pharm Bull. 25:1049–1052. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Wong SL, Chang HS, Wang GJ, Chiang MY, Huang HY, Chen CH, Tsai SC, Lin CH and Chen IS: Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity. J Nat Prod. 74:2489–2496. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Chang WA, Lin ES, Tsai MJ, Huang MS and Kuo PL: Isolinderalactone inhibits proliferation of A549 human non-small cell lung cancer cells by arresting the cell cycle at the G0/g1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway. Mol Med Rep. 9:1653–1659. 2014.PubMed/NCBI

12 

Yu H, Pardoll D and Jove R: STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer. 9:798–809. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Wang CY, Bai XY and Wang CH: Traditional Chinese medicine: A treasured natural resource of anticancer drug research and development. Am J Chin Med. 42:543–559. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, et al: Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res. 12:11–19. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Song H, Wang R, Wang S and Lin J: A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci USA. 102:4700–4705. 2005. View Article : Google Scholar : PubMed/NCBI

16 

White CA and Nicola NA: SOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokines. JAK-STAT. 2:e250452013. View Article : Google Scholar

17 

Collins AS, McCoy CE, Lloyd AT, O'Farrelly C and Stevenson NJ: miR-19a: An effective regulator of SOCS3 and enhancer of JAK-STAT signalling. PLoS One. 8:e690902013. View Article : Google Scholar : PubMed/NCBI

18 

Kneitz B, Krebs M, Kalogirou C, Schubert M, Joniau S, van Poppel H, Lerut E, Kneitz S, Scholz CJ, Ströbel P, et al: Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3. Cancer Res. 74:2591–2603. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Patel K, Kollory A, Takashima A, Sarkar S, Faller DV and Ghosh SK: MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression. Cancer Lett. 347:54–64. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4:42015. View Article : Google Scholar

21 

Garcia DM, Baek D, Shin C, Bell GW, Grimson A and Bartel DP: Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol. 18:1139–1146. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Peter ME: Programmed cell death: Apoptosis meets necrosis. Nature. 471:310–312. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F and Youle RJ: Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J. 22:4385–4399. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, et al: Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 410:549–554. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Li LY, Luo X and Wang X: Endonuclease G is an apoptotic DNase when released from mitochondria. Nature. 412:95–99. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Takahashi R, Deveraux Q, Tamm I, Welsh K, Assa-Munt N, Salvesen GS and Reed JC: A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem. 273:7787–7790. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Obexer P and Ausserlechner MJ: X-linked inhibitor of apoptosis protein - a critical death resistance regulator and therapeutic target for personalized cancer therapy. Front Oncol. 4:1972014. View Article : Google Scholar : PubMed/NCBI

28 

Valencia-Sanchez MA, Liu J, Hannon GJ and Parker R: Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20:515–524. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yen M, Shih Y, Hsu Y, Lin E, Lin Y, Tsai E, Ho Y, Hou M and Kuo P: Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer. Oncol Rep 35: 1356-1364, 2016.
APA
Yen, M., Shih, Y., Hsu, Y., Lin, E., Lin, Y., Tsai, E. ... Kuo, P. (2016). Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer. Oncology Reports, 35, 1356-1364. https://doi.org/10.3892/or.2015.4503
MLA
Yen, M., Shih, Y., Hsu, Y., Lin, E., Lin, Y., Tsai, E., Ho, Y., Hou, M., Kuo, P."Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer". Oncology Reports 35.3 (2016): 1356-1364.
Chicago
Yen, M., Shih, Y., Hsu, Y., Lin, E., Lin, Y., Tsai, E., Ho, Y., Hou, M., Kuo, P."Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer". Oncology Reports 35, no. 3 (2016): 1356-1364. https://doi.org/10.3892/or.2015.4503
Copy and paste a formatted citation
x
Spandidos Publications style
Yen M, Shih Y, Hsu Y, Lin E, Lin Y, Tsai E, Ho Y, Hou M and Kuo P: Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer. Oncol Rep 35: 1356-1364, 2016.
APA
Yen, M., Shih, Y., Hsu, Y., Lin, E., Lin, Y., Tsai, E. ... Kuo, P. (2016). Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer. Oncology Reports, 35, 1356-1364. https://doi.org/10.3892/or.2015.4503
MLA
Yen, M., Shih, Y., Hsu, Y., Lin, E., Lin, Y., Tsai, E., Ho, Y., Hou, M., Kuo, P."Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer". Oncology Reports 35.3 (2016): 1356-1364.
Chicago
Yen, M., Shih, Y., Hsu, Y., Lin, E., Lin, Y., Tsai, E., Ho, Y., Hou, M., Kuo, P."Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer". Oncology Reports 35, no. 3 (2016): 1356-1364. https://doi.org/10.3892/or.2015.4503
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