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Article

IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma

  • Authors:
    • Weipeng Zhao
    • Jun Wang
    • Bo Zhu
    • Yuzhong Duan
    • Fanglin Chen
    • Weiqi Nian
    • Jianguo Sun
    • Bicheng Zhang
    • Zhongsheng Tong
    • Zhengtang Chen
  • View Affiliations / Copyright

    Affiliations: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P.R. China, Department of Oncology, General Hospital, Jinan Command of the People's Liberation Army, Jinan, Shandong 250031, P.R. China, Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China, Department of Oncology, Wuhan General Hospital of Guangzhou Command, People's Liberation Army, Wuhan, Hubei 430070, P.R. China
  • Pages: 1483-1492
    |
    Published online on: December 24, 2015
       https://doi.org/10.3892/or.2015.4516
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Abstract

Lymphangiogenesis is not only involved in the processes of embryonic development, tissue repair and chronic inflammation, but also in tumor lymphatic metastasis. Metastatic tumor cells spreading through lymphatic vessels occur in non-small cell lung carcinoma (NSCLC), with regional lymph node metastasis often being the most important prognostic factor for carcinoma patients. Recent research has identified a range of lymphangiogenic growth factors that could conceivably play a great role in promoting tumor lymphangiogenesis and lymphatic metastasis. The most extensively accepted signaling pathways promoting lymphangiogenesis in tumors include the secreted lymphangiogenic proteins: vascular endothelial growth factor-C (VEGF-C) and VEGF-D, and their cognate receptor on lymphatic endothelium VEGF receptor-3 (VEGFR-3). Targeting VEGF pathway strategy sometimes failed to decrease tumor metastasis in vivo experiments and clinical trials. It is unclear whether the tumor cells induced the lymphangiogenesis process, while VEGF pathway could not completely illustrate the mechanism of tumor cell lymphatic metastasis. To explore the novel tumor lymphangiogenesis targets, we screened 181 candidate genes between high lymphatic vascular density (LVD) and low LVD in lung adenocarcinomas using Human Genome U133 Plus 2.0 Microarray. Insulin-like growth factor binding protein 7 (IGFBP7) was proven to be associated with metastatic clinicopathological features and high LVD. Furthermore, by assessing the capability of lymphatic endothelial cell forming lymphatic vessel-like structures in vitro, it appears to enhance lymphangiogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao W, Wang J, Zhu B, Duan Y, Chen F, Nian W, Sun J, Zhang B, Tong Z, Chen Z, Chen Z, et al: IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma. Oncol Rep 35: 1483-1492, 2016.
APA
Zhao, W., Wang, J., Zhu, B., Duan, Y., Chen, F., Nian, W. ... Chen, Z. (2016). IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma. Oncology Reports, 35, 1483-1492. https://doi.org/10.3892/or.2015.4516
MLA
Zhao, W., Wang, J., Zhu, B., Duan, Y., Chen, F., Nian, W., Sun, J., Zhang, B., Tong, Z., Chen, Z."IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma". Oncology Reports 35.3 (2016): 1483-1492.
Chicago
Zhao, W., Wang, J., Zhu, B., Duan, Y., Chen, F., Nian, W., Sun, J., Zhang, B., Tong, Z., Chen, Z."IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma". Oncology Reports 35, no. 3 (2016): 1483-1492. https://doi.org/10.3892/or.2015.4516
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao W, Wang J, Zhu B, Duan Y, Chen F, Nian W, Sun J, Zhang B, Tong Z, Chen Z, Chen Z, et al: IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma. Oncol Rep 35: 1483-1492, 2016.
APA
Zhao, W., Wang, J., Zhu, B., Duan, Y., Chen, F., Nian, W. ... Chen, Z. (2016). IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma. Oncology Reports, 35, 1483-1492. https://doi.org/10.3892/or.2015.4516
MLA
Zhao, W., Wang, J., Zhu, B., Duan, Y., Chen, F., Nian, W., Sun, J., Zhang, B., Tong, Z., Chen, Z."IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma". Oncology Reports 35.3 (2016): 1483-1492.
Chicago
Zhao, W., Wang, J., Zhu, B., Duan, Y., Chen, F., Nian, W., Sun, J., Zhang, B., Tong, Z., Chen, Z."IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma". Oncology Reports 35, no. 3 (2016): 1483-1492. https://doi.org/10.3892/or.2015.4516
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