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Article

Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells

  • Authors:
    • Jie Tang
    • Hongxuan Zhou
    • Chun Wang
    • Xiaodong Fei
    • Liqun Zhu
    • Yuejiao Huang
    • Yunhua He
    • Jing Liu
    • Xiaobing Miao
    • Yaxun Wu
    • Yuchan Wang
  • View Affiliations / Copyright

    Affiliations: Liyang People's Hospital, Liyang, Jiangsu 213300, P.R. China, Nantong University Cancer Hospital, Nantong, Jiangsu 226001, P.R. China, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu 226001, P.R. China
  • Pages: 1875-1883
    |
    Published online on: December 29, 2015
       https://doi.org/10.3892/or.2015.4532
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Abstract

Previous studies have demonstrated that Homer1b/c plays an important pro-apoptotic role through classical mitochondrial apoptotic pathway. The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma (MM). We found that Homer1b/c was lowly expressed in MM cell apoptotic model induced by doxorubicin. The positive role of Homer1b/c in cell apoptosis was further confirmed by knocking down Homer1b/c. Further study confirmed that Homer1b/c was able to affect the CAM-DR via pro-apoptotic activity regulating the ability of cell adhesion. Collectively, these data indicate that Homer1b/c may represent a good candidate for pursuing clinical trial in MM.
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Copy and paste a formatted citation
Spandidos Publications style
Tang J, Zhou H, Wang C, Fei X, Zhu L, Huang Y, He Y, Liu J, Miao X, Wu Y, Wu Y, et al: Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells. Oncol Rep 35: 1875-1883, 2016.
APA
Tang, J., Zhou, H., Wang, C., Fei, X., Zhu, L., Huang, Y. ... Wang, Y. (2016). Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells. Oncology Reports, 35, 1875-1883. https://doi.org/10.3892/or.2015.4532
MLA
Tang, J., Zhou, H., Wang, C., Fei, X., Zhu, L., Huang, Y., He, Y., Liu, J., Miao, X., Wu, Y., Wang, Y."Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells". Oncology Reports 35.3 (2016): 1875-1883.
Chicago
Tang, J., Zhou, H., Wang, C., Fei, X., Zhu, L., Huang, Y., He, Y., Liu, J., Miao, X., Wu, Y., Wang, Y."Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells". Oncology Reports 35, no. 3 (2016): 1875-1883. https://doi.org/10.3892/or.2015.4532
Copy and paste a formatted citation
x
Spandidos Publications style
Tang J, Zhou H, Wang C, Fei X, Zhu L, Huang Y, He Y, Liu J, Miao X, Wu Y, Wu Y, et al: Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells. Oncol Rep 35: 1875-1883, 2016.
APA
Tang, J., Zhou, H., Wang, C., Fei, X., Zhu, L., Huang, Y. ... Wang, Y. (2016). Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells. Oncology Reports, 35, 1875-1883. https://doi.org/10.3892/or.2015.4532
MLA
Tang, J., Zhou, H., Wang, C., Fei, X., Zhu, L., Huang, Y., He, Y., Liu, J., Miao, X., Wu, Y., Wang, Y."Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells". Oncology Reports 35.3 (2016): 1875-1883.
Chicago
Tang, J., Zhou, H., Wang, C., Fei, X., Zhu, L., Huang, Y., He, Y., Liu, J., Miao, X., Wu, Y., Wang, Y."Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells". Oncology Reports 35, no. 3 (2016): 1875-1883. https://doi.org/10.3892/or.2015.4532
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