Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells

  • Authors:
    • Jie Tang
    • Hongxuan Zhou
    • Chun Wang
    • Xiaodong Fei
    • Liqun Zhu
    • Yuejiao Huang
    • Yunhua He
    • Jing Liu
    • Xiaobing Miao
    • Yaxun Wu
    • Yuchan Wang
  • View Affiliations

  • Published online on: December 29, 2015     https://doi.org/10.3892/or.2015.4532
  • Pages: 1875-1883
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Abstract

Previous studies have demonstrated that Homer1b/c plays an important pro-apoptotic role through classical mitochondrial apoptotic pathway. The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma (MM). We found that Homer1b/c was lowly expressed in MM cell apoptotic model induced by doxorubicin. The positive role of Homer1b/c in cell apoptosis was further confirmed by knocking down Homer1b/c. Further study confirmed that Homer1b/c was able to affect the CAM-DR via pro-apoptotic activity regulating the ability of cell adhesion. Collectively, these data indicate that Homer1b/c may represent a good candidate for pursuing clinical trial in MM.
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March-2016
Volume 35 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Tang J, Zhou H, Wang C, Fei X, Zhu L, Huang Y, He Y, Liu J, Miao X, Wu Y, Wu Y, et al: Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells. Oncol Rep 35: 1875-1883, 2016
APA
Tang, J., Zhou, H., Wang, C., Fei, X., Zhu, L., Huang, Y. ... Wang, Y. (2016). Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells. Oncology Reports, 35, 1875-1883. https://doi.org/10.3892/or.2015.4532
MLA
Tang, J., Zhou, H., Wang, C., Fei, X., Zhu, L., Huang, Y., He, Y., Liu, J., Miao, X., Wu, Y., Wang, Y."Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells". Oncology Reports 35.3 (2016): 1875-1883.
Chicago
Tang, J., Zhou, H., Wang, C., Fei, X., Zhu, L., Huang, Y., He, Y., Liu, J., Miao, X., Wu, Y., Wang, Y."Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells". Oncology Reports 35, no. 3 (2016): 1875-1883. https://doi.org/10.3892/or.2015.4532