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Article

MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration

  • Authors:
    • Hao Xue
    • Xiao Gao
    • Shugang Xu
    • Jinsen Zhang
    • Xing Guo
    • Shaofeng Yan
    • Tong Li
    • Xiaofan Guo
    • Qinglin Liu
    • Gang Li
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 1771-1777
    |
    Published online on: January 5, 2016
       https://doi.org/10.3892/or.2016.4548
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Abstract

The present study was the first to examine the effect of microRNA-Let-7f (miR-Let-7f) inhibiting vasculogenic mimicry (VM) of human glioma cells. The postoperative survival time was significantly poor in VM-positive glioma patients compared with those without VM. Thus, it is reasonable to postulate that miR-Let-7f functions as a potent tumor suppressor by inhibiting glioma VM. However, the molecular mechanisms involved remain poorly clarified. Our preliminary studies revealed that miR-Let-7f suppressed VM by disturbing periostin (POSTN)-induced migration of glioma cells. Our results clearly demonstrated that inhibiting the pro-migratory function of POSTN by the overexpression of miR-Let-7f significantly reduced the formation of VM. Our findings suggest that miR-Let-7f may serve as a potential complementary therapeutic target in the anti‑angiogenesis treatment of gliomas via suppressing VM.
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Copy and paste a formatted citation
Spandidos Publications style
Xue H, Gao X, Xu S, Zhang J, Guo X, Yan S, Li T, Guo X, Liu Q, Li G, Li G, et al: MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration. Oncol Rep 35: 1771-1777, 2016.
APA
Xue, H., Gao, X., Xu, S., Zhang, J., Guo, X., Yan, S. ... Li, G. (2016). MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration. Oncology Reports, 35, 1771-1777. https://doi.org/10.3892/or.2016.4548
MLA
Xue, H., Gao, X., Xu, S., Zhang, J., Guo, X., Yan, S., Li, T., Guo, X., Liu, Q., Li, G."MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration". Oncology Reports 35.3 (2016): 1771-1777.
Chicago
Xue, H., Gao, X., Xu, S., Zhang, J., Guo, X., Yan, S., Li, T., Guo, X., Liu, Q., Li, G."MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration". Oncology Reports 35, no. 3 (2016): 1771-1777. https://doi.org/10.3892/or.2016.4548
Copy and paste a formatted citation
x
Spandidos Publications style
Xue H, Gao X, Xu S, Zhang J, Guo X, Yan S, Li T, Guo X, Liu Q, Li G, Li G, et al: MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration. Oncol Rep 35: 1771-1777, 2016.
APA
Xue, H., Gao, X., Xu, S., Zhang, J., Guo, X., Yan, S. ... Li, G. (2016). MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration. Oncology Reports, 35, 1771-1777. https://doi.org/10.3892/or.2016.4548
MLA
Xue, H., Gao, X., Xu, S., Zhang, J., Guo, X., Yan, S., Li, T., Guo, X., Liu, Q., Li, G."MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration". Oncology Reports 35.3 (2016): 1771-1777.
Chicago
Xue, H., Gao, X., Xu, S., Zhang, J., Guo, X., Yan, S., Li, T., Guo, X., Liu, Q., Li, G."MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration". Oncology Reports 35, no. 3 (2016): 1771-1777. https://doi.org/10.3892/or.2016.4548
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